Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2010 | 70 | 4 |
Tytuł artykułu

Anticonvulsant effect of celecoxib on pentylenetetrazoleinduced convulsion: modulation by NO pathway

Treść / Zawartość
Warianty tytułu
Języki publikacji
This study aimed to examine whether celecoxib influences clonic seizure thresholds through modulation of nitric oxidergic (NO) pathway. The effect of celecoxib (1-5 mg/kg, p.o.) was investigated on clonic seizures induced by pentylenetetrazole (PTZ, 50 and 80 mg/kg, i.p.) in male Swiss mice. The interaction of celecoxib-induced effects with NO pathway was examined using a NO synthase (NOS) inhibitor, N(G)-omega-nitro-L-arginine methyl ester (L-NAME, 20 and 50 mg/kg, i.p.) and a NOS substrate, L-arginine (100 and 200 mg/kg, i.p.). The criteria for the development of seizure activity were the possibility for appearance of generalized clonus and prolongation of latency to the onset of convulsions following administration of 50 and 80 mg/kg of PTZ, respectively. Pretreatment with celecoxib (2.5 and 5 mg/kg) or L-NAME (50 mg/ kg) induced anticonvulsant effect on the PTZ-induced clonic seizures. L-arginine at the dose of 200 mg/kg had proconvnlsant effect. A sub-effective dose of celecoxib (1 mg/kg) induced an additive anticonvulsant effect when co-administered with L-NAME (20 mg/kg). Although L-arginine (100 mg/kg) per se did not influence PTZ-induced convulsion, it could attenuate the anticonvulsant effect of celecoxib (5 mg/kg). Our results indicate that celecoxib induces an anticonvulsant effect on clonic seizure threshold that may involve NO pathway.
Słowa kluczowe
Opis fizyczny
  • Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Abramson SB, Attur M, Amin AR, and Clancy R (2001) Nitric oxide and inflammatory mediators in the perpetua­tion of osteoarthritis. Curr Rheumatol Rep 3: 535-41.
  • Akarsu ES, Ozdayi S, Algan E, and Ulupinar F (2006) The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction. Epilepsy Res 71: 181-7.
  • Arancio O, Antonova I, Gambaryan S, Lohmann SM, Wood JS, Lawrence DS, and Hawkins RD (2001) Presynaptic role of cGMP-dependent protein kinase during long-last­ing potentiation. J Neurosci 21: 143-9.
  • Beierwaltes WH (2002) Cyclooxygenase-2 products com­pensate for inhibition of nitric oxide regulation of renal perfusion. Am J Physiol Renal Physiol 283: F68-72.
  • Bliss TV, and Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361: 31-9.
  • Bon CL, and Garthwaite J (2003) On the role of nitric oxide in hippocampal long-term potentiation. J Neurosci 23: 1941-8.
  • Bredt DS (1999) Endogenous nitric oxide synthesis: bio­logical functions and pathophysiology. Free Radic Res 31: 577-96.
  • Bredt DS, and Snyder SH (1989) Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci U S A 86: 9030-3.
  • Chen C, and Bazan NG (2005) Endogenous PGE2 regulates membrane excitability and synaptic transmission in hip­pocampal CA1 pyramidal neurons. J Neurophysiol 93: 929-41.
  • Chen C, Magee JC, and Bazan NG (2002) Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity. J Neurophysiol 87: 2851-7.
  • Choi SH, Aid S, and Bosetti F (2009) The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implica­tions for translational research. Trends Pharmacol Sci 30: 174-81.
  • Davel L, D'Agostino A, Espanol A, Jasnis MA, Lauria de Cidre L, de Lustig ES, and Sales ME (2002) Nitric oxide synthase-cyclooxygenase interactions are involved in tumor cell angiogenesis and migration. J Biol Regul Homeost Agents 16: 181-9.
  • Dhir A, and Kulkarni SK (2006) Rofecoxib, a selective cycloox­ygenase-2 (COX-2) inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced con­vulsions in mice. Inflammopharmacology 14: 222-5.
  • Dhir A, Naidu PS, and Kulkarni SK (2006) Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)- induced convulsions: Possible mechanism of action. Prog Neuropsychopharmacol Biol Psychiatry 30: 1478-85.
  • Dudhgaonkar SP, Tandan SK, Kumar D, Naik AK, and Raviprakash V (2007) Ameliorative effect of combined administration of inducible nitric oxide synthase inhibitor with cyclooxygenase-2 inhibitors in neuropathic pain in rats. Eur J Pain 11: 528-34.
  • Feil R, and Kleppisch T (2008) NO/cGMP-dependent modu­lation of synaptic transmission. Handb Exp Pharmacol 184: 529-60.
  • Garthwaite J, Charles SL, and Chess-Williams R (1988) Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular mes­senger in the brain. Nature 336: 385-8.
  • Gholipour T, Jabbarzadeh A, Riazi K, Rasouli A, Nezami BG, Sharifzadeh M, and Dehpour AR (2008) Role of nitric oxide in the anticonvulsive effect of progesterone. Epilepsy Behav 13: 579-84.
  • Hewett SJ, Uliasz TF, Vidwans AS, and Hewett JA (2000) Cyclooxygenase-2 contributes to N-methyl-D-aspartate- mediated neuronal cell death in primary cortical cell cul­ture. J Pharmacol Exp Ther 293: 417-25.
  • Hoffman M (1991) A new role for gases: neurotransmission. Science 252: 1788.
  • Homayoun H, Khavandgar S, and Dehpour AR (2002) Anticonvulsant effects of cyclosporin A on pentylenetet- razole-induced seizure and kindling: modulation by nitri- coxidergic system. Brain Res 939: 1-10.
  • Hughes FJ, Buttery LD, Hukkanen MV, O'Donnell A, Maclouf J, and Polak JM (1999) Cytokine-induced pros- taglandin E2 synthesis and cyclooxygenase-2 activity are regulated both by a nitric oxide-dependent and -indepen­dent mechanism in rat osteoblasts in vitro. J Biol Chem 274: 1776-82.
  • Itoh K, Watanabe M, Yoshikawa K, Kanaho Y, Berliner LJ, and Fujii H (2004) Magnetic resonance and biochemical studies during pentylenetetrazole-kindling development: the relationship between nitric oxide, neuronal nitric oxide synthase and seizures. Neuroscience 129: 757-66.
  • Kelley KA, Ho L, Winger D, Freire-Moar J, Borelli CB, Aisen PS, and Pasinetti GM (1999) Potentiation of exci- totoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am J Pathol 155: 995-1004.
  • Kim HJ, Chung JI, Lee SH, Jung YS, Moon CH, and Baik EJ (2008) Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors. Brain Res 1193: 153-61.
  • Kim SF, Huri DA, and Snyder SH (2005) Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310: 1966-70.
  • Lazarewicz JW, Salinska E, Stafiej A, Ziembowicz A, and Zieminska E (2000) NMDA receptors and nitric oxide regulate prostaglandin D2 synthesis in the rabbit hippocam­pus in vivo. Acta Neurobiol Exp (Wars) 60: 427-35.
  • Loscher W, and Schmidt D (1988) Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical consider­ations. Epilepsy Res 2: 145-81.
  • Luszczki JJ, Szadkowski M, and Czuczwar SJ (2007) Effect of NG-nitro-L-arginine on the anticonvulsant action of four second-generation antiepileptic drugs in pentetra- zole-induced clonic seizures in mice. Pharmacol Rep 59: 467-73.
  • Mebazaa A, De Keulenaer GW, Paqueron X, Andries LJ, Ratajczak P, Lanone S, Frelin C, Longrois D, Payen D, Brutsaert DL, and Sys SU (2001) Activation of cardiac endothelium as a compensatory component in endotoxin- induced cardiomyopathy: role of endothelin, prostaglan- dins, and nitric oxide. Circulation 104: 3137-44.
  • Mollace V, Muscoli C, Masini E, Cuzzocrea S, and Salvemini D (2005) Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol Rev 57: 217-52.
  • Moncada S, Palmer RM, and Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-42.
  • Nidhi G, Balakrishnan S, and Pandhi P (1999) Role of nitric oxide in electroshock and pentylenetetrazol seizure thresh­old in rats. Methods Find Exp Clin Pharmacol 21: 609-12.
  • Noh HS, Kim DW, Cho GJ, Choi WS, and Kang SS (2006) Increased nitric oxide caused by the ketogenic diet reduc­es the onset time of kainic acid-induced seizures in ICR mice. Brain Res 1075: 193-200.
  • Oliveira MS, Furian AF, Royes LF, Fighera MR, Fiorenza NG, Castelli M, Machado P, Bohrer D, Veiga M, Ferreira J, Cavalheiro EA, and Mello CF (2008) Cyclooxygenase-2/ PGE2 pathway facilitates pentylenetetrazol-induced sei­zures. Epilepsy Res 79: 14-21.
  • Reid IC, and Stewart CA (1997) Seizures, memory and syn­aptic plasticity. Seizure 6: 351-9.
  • Riazi K, Roshanpour M, Rafiei-Tabatabaei N, Homayoun H, Ebrahimi F, and Dehpour AR (2006) The proconvulsant effect of sildenafil in mice: role of nitric oxide-cGMP pathway. Br J Pharmacol 147: 935-43.
  • Salvemini D (1997) Regulation of cyclooxygenase enzymes by nitric oxide. Cell Mol Life Sci 53: 576-82.
  • Salvemini D, Manning PT, Zweifel BS, Seibert K, Connor J, Currie MG, Needleman P, and Masferrer JL (1995) Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. J Clin Invest 96: 301-8.
  • Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, and Needleman P (1993) Nitric oxide activates cyclooxy­genase enzymes. Proc Natl Acad Sci U S A 90: 7240-4.
  • Simmons DL, Botting RM, and Hla T (2004) Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 56: 387-437.
  • Strauss KI, and Marini AM (2002) Cyclooxygenase-2 inhibi­tion protects cultured cerebellar granule neurons from glu- tamate-mediated cell death. J Neurotrauma 19: 627-38.
  • Tayal V, Kalra BS, and Chawla S (2008) Effect of celecoxib on anticonvulsant activity of carbamazepine against maximal electroshock-induced convulsions in mice. Methods Find Exp Clin Pharmacol 30: 727-30.
  • Toscano CD, Kingsley PJ, Marnett LJ, and Bosetti F (2008) NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. Neurotoxicology 29: 1114-20.
  • Tutka P, Barczynski B, and Wielosz M (2004) Convulsant and anticonvulsant effects of bupropion in mice. Eur J Pharmacol 499: 117-20.
  • Uzum G, Akgun-Dar K, Bahcekapili N, Diler AS, and Ziylan YZ (2005) Nitric oxide involvement in seizures elicited by pentylentetrazol and sex dependence. Int J Neurosci 115: 1503-14.
  • Vane JR, BakhleYS, and Botting RM (1998) Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38: 97-120.
  • Wesolowska A, Nikiforuk A, and Chojnacka-Wojcik E (2006) Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice. Eur J Pharmacol 541: 57-63.
  • Wojtal K, Gniatkowska-Nowakowska A, and Czuczwar SJ (2003) Is nitric oxide involved in the anticonvulsant action of antiepileptic drugs? Pol J Pharmacol 55: 535-42.
  • Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, and Worley PF (1993) Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11: 371-86.
  • Yang H, and Chen C (2008) Cyclooxygenase-2 in synaptic signaling. Curr Pharm Des 14: 1443-51.
  • Zhou L, and Zhu DY (2009) Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide 20: 223-30.
Rekord w opracowaniu
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.