Wirusy grypy ptaków - molekularne determinanty patogenności, lekooporności i adaptacji do organizmu gospodarza

• Autorzy: Smietanka K. , Minta Z.

Warianty tytułu

EN

Avian influenza viruses: molecular determinants of pathogenicity, drug resistance and host adaptation

• Języki publikacji: PL

Abstrakty

EN

The paper reviews molecular markers and determinants associated with virulence, host adaptation and drug resistance in avian influenza viruses (AIV). The virulence of AIV is mostly dependant on the presence of multiple amino acids (mainly arginine and lysine) at the cleavage site of the haemagglutinin (HA) protein. The major factors contributing to host adaptation are also harbored within the HA protein: amino acids at positions 226 and 228 determine virus binding affinity to receptors present in cell membranes of birds or humans. It has been shown that pathogenicity and host adaptation are also dependant on the amino acid sequences of the polymerase complex (PB2-PB1-PA) and the most significant mutation (E627K in PB2) is related to the increased replication of the virus in mammalian cells. Molecular markers associated with an increased resistance to antiviral drugs are localized in neuraminidase (NA) and matrix (M) proteins. For example, a histidine to tyrosine substitution at position 274 of NA (H274Y) decreases viral susceptibility to neuraminidase inhibitors (e.g. oseltamivir), the most frequently used drugs in flu treatment. Monitoring of the molecular changes in the viral genome of AIV is very important from an epidemiological point of view and can be a valuable part of an early warning system.

Słowa kluczowe

PL

wirus influenzy ptakow; patogennosc; adaptacja do organizmu gospodarza; lekoopornosc; hemaglutyniny; neuroaminidaza; kompleks polimerazy; bialka matriks; bialka niestrukturalne

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2011
• Tom: 67
• Numer: 06
• Opis fizyczny: s.372-375,tab.,bibliogr.

Twórcy

autor

Smietanka K.

• Zakład Chorób Drobiu, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy, Al.Partyzantów 57, 24-100 Puławy

autor

Minta Z.

Bibliografia

• 1. Cox N. J., Uyeki T. M.: Public health implications of avian influenza viruses, [w:] Swayne D. E. (ed.): Avian influenza. Blackwell Publishing, Ames, Iowa 2008, 453-484.
• 2. Fouchier R. A., Schneeberger P. M., Rozendaal F. W., Broekman J. M., Kemink S. A., Munster V., Kuiken T., Rimmelzwaan G. F., Schutten M., Van Doornum G. J., Koch G., Bosman A., Koopmans M., Osterhaus A. D.: Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome. Proc. Natl Acad. Sci. USA 2004, 101, 1356-1361.
• 3. Gabriel G., Herwig A., Klenk H. D.: Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus. PLoS Pathog. 2008, 4, e11.
• 4. Govorkova E. A., Rehg J. E., Krauss S., Yen H. L., Guan Y., Peiris M., Nguyen T. D., Hanh T. H., Puthavathana P., Long H. T., Buranathai C., Lim W., Webster R. G., Hoffmann E.: Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J. Virol. 2005, 79, 2191-2198.
• 5. Hatta M., Gao P. P., Halfmann P., Kawaoka Y.: Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 2001, 293, 1840-1842.
• 6. Hulse D. J., Webster R. G., Russell R. J., Perez D. R.: Molecular determinants within the surface proteins involved in the pathogenicity of H5N1 influenza viruses in chickens. J. Virol. 2004, 78, 9954-9964.
• 7. Jong M. D., Simmons C. P., Thanh T. T., Hien V. M., Smith G. J., Chau T. N., Hoang D. M., Chau N. V., Khanh T. H., Dong V. C., Qui P. T., Cam B. V., Ha Q. D., Guan Y., Peiris J. S., Chinh N. T., Hien T. T., Farrar J.: Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat. Med. 2006, 12, 1203-1207.
• 8. Jong M. D. de, Thanh T. T., Khanh T. H., Hien V. M., Smith G. J. D., Chau N. V., Cam B. V., Qui P. T., Ha D. Q., Guan Y., Peiris J. S. M., Hien T. T., Farrar J.: Brief report - Oseltamivir resistance during treatment of influenza A (H5N1) infection. N. Engl. J. Med. 2005, 353, 2667-2672.
• 9. Kawaoka Y., Webster R. G.: Evolution of the A/Chicken/Pennsylvania/83 (H5N2) influenza virus. Virology 1985, 146, 130-137.
• 10. Matrosovich M., Stech J., Klenk H. D.: Influenza receptors, polymerase and host range. Rev. - Off. Int. Epizoot. 2009, 28, 203-217.
• 11. Matsuoka Y., Swayne D. E., Thomas C., Rameix-Welti M. A., Naffakh N., Warnes C., Altholtz M., Donis R., Subbarao K.: Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice. J. Virol. 2009, 83, 4704-4708.
• 12. Minta Z., Śmietanka K., Domańska-Blicharz K., Tomczyk G., Wijaszka T.: Wysoce zjadliwa grypa ptaków u dzikich ptaków w Polsce – analiza pierwszych przypadków. Medycyna Wet. 2007, 63, 1349-1352.
• 13. Perdue M. L.: Molecular determinants of pathogenicity for avian influenza viruses, [w:] Swayne D. E. (ed.): Avian influenza. Blackwell Publishing, Ames, Iowa 2008, 23-41.
• 14. Piekarowicz A.: Podstawy wirusologii molekularnej. Wydawnictwo Naukowe PWN, Warszawa 2004, s. 612.
• 15. Puthavathana P., Auewarakul P., Charoenying P. C., Sangsiriwut K., Pooruk P., Boonnak K., Khanyok R., Thawachsupa P., Kijphati R., Sawanpanyalert P.: Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand. J. Gen. Virol. 2005, 86, 423-433.
• 16. Sims L. D., Brown I. H.: Multicontinental epidemic of H5N1 HPAI virus (1996-2007), [w:] Swayne D. E. (ed.): Avian influenza. Blackwell Publishing, Ames, Iowa 2008, 251-286.
• 17. Smietanka K., Fusaro A., Domanska-Blicharz K., Salviato A., Monne I., Dundon W. G., Cattoli G., Minta Z.: Full-length genome sequencing of the polish HPAI H5N1 viruses suggests separate introductions in 2006 and 2007. Avian Dis. 2010, 54 (suppl), 335-339.
• 18. Swayne D. E., Halvorson D. A.: Influenza, [w:] Diseases of Poultry. Blackwell Publishing, Ames, Iowa 2008, 153-184.
• 19. Śmietanka K., Minta Z., Domańska-Blicharz K., Tomczyk G., Wijaszka T., Związek J., Batorczak Z., Bartoszewicz L.: Przypadki wysoce zjadliwej grypy ptaków H5N1 w Polsce w 2007 roku. Medycyna Wet. 2009, 65, 115-118.
• 20. Taubenberger J. K., Reid A. H., Lourens R. M., Wang R., Jin G., Fanning T. G.: Characterization of the 1918 influenza virus polymerase genes. Nature 2005, 437, 889-893.
• 21. Vines A., Wells K., Matrosovich M., Castrucci M. R., Ito T., Kawaoka Y.: The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction. J. Virol. 1998, 72, 7626-7631.