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1989 | 40 | 5-6 |
Tytuł artykułu

Effect of duodenal trypsin on pancreatic secretion in men

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Czajkowski A.and Długosz J.: Effect of duodenal trypsin on pancreatic secretion in men. Acta physiol, pol., 1989,40 (5-6): 486-495. The effect of tryptic activity in duodenum on L-phenylalanine (100 mmol·1⁻¹ intraduodenally) stimulated pancreatic Secretion in 18 healthy volunteers has been evaluated. Intraduodenal infusion of trypsin (150 mg) during 1 h caused the reduction of α-amylase and lipase output by ca 30%. The infusion of aprotinin at the dose of 0.5 · 10⁶ KIU during 30 min caused return of the α-amylase and lipase output to the pretryptic values. The infusion of trypsin in higher dose (300 mg) caused more pronounced decrease of α-amylase and lipase output (ca 45%). Our data indicate that active trypsin in duodenum is responsible for the inhibition of L-phenylalanine stimulated pancreatic enzyme secretion in man. These results corroborate the existence of feedback regulation of stimulated pancreatic secretion by intraduodenal trypsin in man.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
40
Numer
5-6
Opis fizyczny
p.486-495,fig.,ref.
Twórcy
  • Gastroenterology Department, School of Medicine, Bialystok, Poland
autor
  • Gastroenterology Department, School of Medicine, Bialystok, Poland
Bibliografia
  • 1. Andren-Sandberg, A., Ihse, I. (1983) Regulatory effect on the pancreas of intraduodenal pancreatic juice and trypsin in the Syrian golden hamster. Scand. J. Gastroenterol. 18. 697-706.
  • 2. Boyd, E. J. S., Cumming, J. G. R., Cushieri, A., Wormsley, K. G. (1985) Aspects of feedback control of pancreatic secretion in man. Ital. J. Gastroenterol. 17. 18-22.
  • 3. Bucko, A., Kopec, Z. (1974) Vyżiva a pankreas, pp. 29-31, Veda, Vydavatel’stwo Slovenskej Akademie Vied. Bratislava.
  • 4. Długosz, J. Fölsch, U. R., Creutzfeldt, W. (1983) Inhibition of intraduodenal trypsin does not stimulate exocrine pancreatic secretion in man. Digestion 26. 197-204.
  • 5. Ertan, A., Brooks, F. P., Ostrow, J. D., Arwan, D. A., Williams, C. N., Creda, J. J. (1971) Effect of jejunal amino acid perfusion and exogenous cholecystokinin on the exocrine pancreatic and biliary secretion in man. Gastroenterology 61. 686-692.
  • 6. Fölsch, U. R., Cantor, P., Wilms, H. M., Schafmayer, A., Becker, H. D., Creutzfeld, W. (1987) Role of cholecystokinin in the negative feedback control of pancreatic enzyme secretion in conscious rats. Gastroenterology 92. 449-458.
  • 7. Green, G. M., Lyman, R. L. (91972) Feedback regulation of pancreatic enzyme secretion as a mechanism for trypsin inhibitor-induced hypersecretion in rats. Proc. Soc. Exp. Biol. Med. 140. 6-12.
  • 8. Homolka, J. (1971) Biochemia kliniczna. Interpretacja i metodyka, pp. 495-496, PZWL, Warszawa.
  • 9. Hotz, J., Ho, S. B., Go, V. L. W., Di Magno, E. P. (1983) Short term inhibition of duodenal tryptic activity does not affect human pancreatic, biliary or gastric function, J. Lab. Clin. Med. 101. 488-495.
  • 10. Ihse, I., Lilja, P., Lundquist, I. (1977) Feedback regulation of pancreatic enzyme secretion by intestinal trypsin in man. Digestion 15. 303-308.
  • 11. Ihse, I., Lilja, P., Lundquist, I. (1979) Trypsin as a regulator of pancreatic secretion in the rat. Scand. J. Gastroenterol. 14. 873-880.
  • 12. King, J. (1965) Practical Clinical Enzymology, ed. D. van Nostrand, pp. 252-260, D. van Nostrand Co. Ltd. London.
  • 13. Krawisz, B. R. (1980) In the absence of nutrients, pancreatic biliary secretions in the jejunum do not exert feedback control of human pancreatic or gastric function. J. Lab. Clin. Med. 95. 13-18.
  • 14. Liener, I. E., Goodale, R. L., Deshmukh, A., Satterberg, T. L., Ward, G., DiPietro, С. M., Bankey, P. E., Bomer, J. W. (1988) Effect of trypsin inhibitor from soy-beans (Bowman-Birk) on the secretory activity of the human pancreas. Gastroenterology 94. 419-427.
  • 15. Lowry, О. H., Rosenbrough, N. T., Farr, A. L., Randal, R. J. (1951) Protein measurement with Folin phenol reagent. J. Biol. Chem. 193. 265-274.
  • 16. Malaver, S. J., Powell, D. W. (1967) An improved turbidimetric analysis of polyethylene glycol utilising an emulsifier. Gastroenterology 53. 250-256.
  • 17. Nagel, W., Willig, F., Peschke, W., Schmidt, F. H. (1965) Über der Bestimmung von Trypsin und Chymotrypsin mit Aminosaure-p-nitroaniliden. Hope-Seyler's Z. Physiol. Chem. 340. 1-10.
  • 18. Osnes, M., Hanssen, D. E. (1980) The influence of intraduodenal administration of pancreatic juice on the bile-induced pancreatic secretion and immunoreactive secretin release in man. Scand J. Gastroenterol. 15. 1041-1047.
  • 19. Owyang, C., Louie, D. S., Tatum, D. (1986) Feedback regulation of pancreatic enzyme secretion. Suppression of cholecystokinin release by trypsin. J. Clin. Invest. 77. 2042-2047.
  • 20. Rick, W., Stegbauer, H. P. (1970) α-Amylase, Messung der reduzierenden Gruppen. In Methoden der enzymatischen Analyse, ed. H. Bergmeyer, pp. 848-853, Verlag Chemie, Weinheim.
  • 21. Sale, J. K., Goldberg, D. M., Fawcet, A. N., Wormsley, K. G. (1977) Chronic and acute studies indicating absence of exocrine pancreatic feedback inhibition in dogs. Digestion 15. 540-555.
  • 22. Slaff, J., Jacobson, D., Tillman, C. R., Curington, C., Toskes, P. (1984) Protease-specific suppression of pancreatic exocrine secretion. Gastroenterology 87. 44-52.
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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