Effect of duodenal trypsin on pancreatic secretion in men

• Autorzy: Czajkowski A. , Dlugosz J.
• Języki publikacji: EN

Abstrakty

EN

Czajkowski A.and Długosz J.: Effect of duodenal trypsin on pancreatic secretion in men. Acta physiol, pol., 1989,40 (5-6): 486-495. The effect of tryptic activity in duodenum on L-phenylalanine (100 mmol·1⁻¹ intraduodenally) stimulated pancreatic Secretion in 18 healthy volunteers has been evaluated. Intraduodenal infusion of trypsin (150 mg) during 1 h caused the reduction of α-amylase and lipase output by ca 30%. The infusion of aprotinin at the dose of 0.5 · 10⁶ KIU during 30 min caused return of the α-amylase and lipase output to the pretryptic values. The infusion of trypsin in higher dose (300 mg) caused more pronounced decrease of α-amylase and lipase output (ca 45%). Our data indicate that active trypsin in duodenum is responsible for the inhibition of L-phenylalanine stimulated pancreatic enzyme secretion in man. These results corroborate the existence of feedback regulation of stimulated pancreatic secretion by intraduodenal trypsin in man.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1989
• Tom: 40
• Numer: 5-6
• Opis fizyczny: p.486-495,fig.,ref.

Twórcy

autor

Czajkowski A.

• Gastroenterology Department, School of Medicine, Bialystok, Poland

autor

Dlugosz J.

• Gastroenterology Department, School of Medicine, Bialystok, Poland

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