Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2012 | 15 | 2 |
Tytuł artykułu

The influence of steroids on noradrenaline-mediated contractile reactivity of the superficial nasal and facial veins in cycling gilts

Treść / Zawartość
Warianty tytułu
Języki publikacji
The nasal venous blood may be directed through the facial vein into the systemic circulation or through the frontal vein into the venous cavernous sinus of the perihypophyseal vascular complex, where hormones and pheromones permeate from the venous blood into the arterial blood supplying the brain and hypophysis. The present study was designed to determine the effect of noradrenaline (NA) on the tension of the nasal, frontal and facial veins of cycling gilts, and influence of ovarian steroid hormones on NA-mediated contractile reactivity. Additionally, the enzyme dopamine-β-hydroxylase catalysing the conversion of dopamine to noradrenaline (DβH) was immunolocalized in these vessels. Among three studied veins, the frontal proximal vein, that fulfill a key role in the supply of the nasal venous blood into the venous cavernous sinus, reacted to NA most strongly (P<0.001) and this reaction was weaker in the periestrous period than in luteal phase (P<0.001). Inversely, the reaction to NA of the facial proximal vein, that carry blood to the peripheral circulation, was stronger in the periestrous period than in luteal phase (P<0.05). P4, E2 and T significantly lowered NA-mediated tension of the frontal proximal vein during the periestrous period (P<0.001), while in the luteal phase P4 might antagonize relaxing effect of E2 to this vessel. The result suggests that supply of the nasal venous blood into the venous cavernous sinus is greater during the periestrous period than during the luteal phase. DβH was clearly expressed in the muscular layer of the isolated superficial nasal and facial veins of gilts in both studied stages of the estrous cycle. We suggest that the reactivity of the superficial veins of the nose and face to NA combined with the previously demonstrated reactivity of these veins to steroid ovarian hormones and male steroid pheromones may regulate the access of priming pheromone androstenol (resorebed in the nasal cavity) to the brain of gilts during periestrous period via humoral local destination transfer.
Słowa kluczowe
Opis fizyczny
  • Department of Local Physiological Regulation, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland
  • Aboud R, Shafii M, Docherty JR (1993) Investigation of the subtypes of α1-adrenoceptor mediating contractions of rat aorta, vas deferens and spleen. Br J Pharmacol 109: 80-87.
  • Baker MA, Nijland MJ (1993) Selective brain cooling in goats: effects of exercise and dehydration. J Physiol 471: 679-692.
  • Berezan DJ, Xu Y, Falck JR, Kundu AP, Davidge ST (2008) Ovariectomy, but not estrogen deficiency, increases CYP4A modulation of alpha (1)-adrenergic vasoconstriction in aging female rats. Am J Hypertens 21: 685-690.
  • Berridge TL, Roach AG (1986) Characterization of h-adrenoceptors in the vasculature of the canine nasal mucosa. Br J Pharmacol 88: 345-354.
  • Daniel PM, Dawes JD, Prichard ML (1953) Studies of the carotid rete and its associated arteries. Phil Trans Roy Sci B London 237: 173-208.
  • Flavahan NA, Cooke JP, Shepherd JT, Vanhoutte PM (1987) Human postjunctional alpha-1 and alpha-2 adrenoceptors: differential distribution in arteries of the limbs. J Pharmacol Exp Ther 241: 361-365.
  • Flavahan NA, Vanhoutte PM (1986) α1-Adrenoceptor subclassification in vascular smooth muscle. Trends Pharmacol Sci 7: 347-349.
  • Ford SP, Reynolds LP, Farley DB, Bhatnagar RK, Van Orden DE (1984) Interaction of ovarian steroids and periarterial α1-adrenergic receptors in altering uterine blood flow during the estrous cycle of gilts. Am J Obstet Gynecol 150: 480-484.
  • Godynicki S, Skorupski M (1979) Drogi odpływu krwi żylnej z jamy nosowej u jelenia, daniela i sarny. Roczniki Akademii Rolniczej Poznań, CXI: 59-69.
  • Grzegorzewski WJ (2005) The influence of male pheromones on the contractile reactivity of the isolated superficial veins of the nose and face during the estrous cycle in gilts. Pol J Vet Sci 8: 57-64.
  • Grzegorzewski WJ (2006) The influence of boar pheromones on the vasoreactivity of the facial superficial veins in the ovariectomized and estradiol-treated pubertal gilts. Pol J Vet Sci 4: 219-225.
  • Grzegorzewski WJ (2006a) The influence of boar pheromones on the contractile reactivity of the isolated superficial veins of the nose and face in ovariectomized prepubertal gilts and in gilts during sexual maturation. Pol J Vet Sci 9: 127-133.
  • Grzegorzewski WJ, Chłopek J, Tabęcka-Łonczyńska A, Stefańczyk-Krzymowska S (2010) The influence of steroids on vascular tension of isolated superficial veins of the nose and face during the estrous cycle in gilts.Theriogenology 73: 215-224.
  • Grzegorzewski WJ, Muszak J, Tabęcka-Łonczyńska A, Stefańczyk-Krzymowska S (2010a) The influence of steroids on the vascular tension of isolated superficial nasal and facial veins in gilts during sexual maturation. Pol J Vet Sci 13: 253-261.
  • Guimaraes S, Moura D (2001) Vascular adrenoceptors: an update. Pharmacol Rev 53: 319-356.
  • Guimaraes S, Nunes JP (1990) The effectiveness of α2-adrenoceptor activation increases from the distal to the proximal part of the veins of the canine limbs. Br J Pharmacol 101: 387-393.
  • Han C, Li J, Minneman KP (1990) Subtypes of α1-adrenoceptors in rat blood vessels. Eur J Pharmacol 190: 97-104.
  • Krzymowski T, Grzegorzewski W, Stefańczyk-Krzymowska S, Skipor J, Wąsowska B (1999) Humoral pathway for transfer of the boar pheromone, androstenol from the nasal mucosa to the brain and hypophysis of gilts. Theriogenology 52: 1225-1240.
  • Krzymowski T, Skipor J, Grzegorzewski W (1992) Cavernous sinus and carotid rete of sheep and sows as a possible place for countercurrent exchange of some neuropeptides and steroid hormones. Anim Reprod Sci 29: 225-240.
  • Krzymowski T, Stefańczyk-Krzymowska S (2012) Local retrograde and destination transfer of physiological regulators as an important regulatory system and its role. Facts and hypothesis. J Physiol Pharmacol 63: 3-16.
  • Krzymowski T, Stefańczyk-Krzymowska S, Grzegorzewski W, Skipor J, Wąsowska B (2001) A possible humoral pathway for the priming action of the male pheromone androstenol on female pigs. In: Marchlewska-Koj A, Lepri JJ, Müller-Schwarze D (eds. ), Chemical Signals in Vertebrates 9, Kluwer Academic/Plenum Publishers, New York, pp. 117-123.
  • Lacroix JS, Kurt AM, Auberson S, Bretton C (1995) Beta-adrenergic mechanisms in the nasal mucosa vascular bed. Eur Arch Otorhinolaryngol 252: 298-303.
  • Lacroix JS, Lundberg JM (1989) Sympathetic vascular control of the pig nasal mucosa: adrenoceptor mechanisms in blood flow and volume control. Br J Pharmacol 97: 1075-1084.
  • Lung MA, Phipps RJ, Wang JC, Widdicombe JG (1984) Control of nasal vasculature and airway resistance in the dog. J Physiol 349: 535-551.
  • Lung MA, Wang JC (1989) Autonomic nervous control of nasal vasculature and airflow resistance in the anaesthetized dog. J Physiol 419: 121-139.
  • Mitchell J, Thomalla L, Mitchell G (1998) Histological studies of the dorsal nasal, angularis oculi and facial veins of sheep (Ovis aries). J Morphol 237: 275-281.
  • Müller-Schweinitzer E (1984) Alpha-adrenoceptors, 5-hydroxytryptamine receptors and the action of dihydroergotamine in human venous preparations obtained during saphenectomy procedures for varicose veins. Naunyn Schmiedebergs Arch Pharmacol 327: 299-303.
  • Polónia JJ, Paiva MQ, Guimaraes S (1985) Pharmacological characterization of postsynaptic h-adrenoceptor subtypes in five different dog arteries in vitro. J Pharm Pharmacol 37: 205-208.
  • Skipor J, Grzegorzewski W, Einer-Jensen N, Wąsowska B (2003) Local vascular pathway for progesterone transfer to the brain after nasal administration in gilts. Reprod Biol 3: 143-159.
  • Stefańczyk-Krzymowska S, Krzymowski T, Grzegorzewski W, Wąsowska B, Skipor J (2000) Humoral pathway for local transfer of the priming pheromone androstenol from the nasal cavity to the brain and hypophysis in anaesthetized gilts. Exp Physiol 85: 801-809.
  • Stefańczyk-Krzymowska S, Krzymowski T, Wąsowska B, Jana B, Słomiński J (2003) Intramuscular injections of male pheromone 5α-androstenol change the secretory ovarian function in gilts during sexual maturation. Reprod Biol 3: 241-257.
  • Stefańczyk-Krzymowska S, Wąsowska B, Jana B (2002) Boar pheromone androstenol may affect the ovarian morphology in cycling gilts by humoral pathway. Folia Histochem Cytobiol 40: 155-156.
  • Stefańczyk-Krzymowska S, Wąsowska B, Skipor J (2005) The effect of intramuscular injections of boar pheromone 5h-androstenol on the hormonal regulation of the estrous cycle in hypoosmatic gilts. Pol J Vet Sci 8: 85-91.
  • Tsang S, Wu S, Liu J, Wong TM (2008) Testosterone protects rat hearts against ischaemic insults by enhancing the effects of α1-adrenoceptor stimulation. Br J Pharmacol 153: 693-709.
  • Vacca G, Battaglia A, Grossini E, Mary DA, Molinari C, Surico N (1999) The effect of 17β-oestradiol on regional blood flow in anaesthetized pigs. J Physiol 514: 875-884.
  • Wang M, Lung MA (2003) Adrenergic mechanisms in canine nasal venous systems. Br J Pharmacol 138: 145-155.
  • Zezula-Szpyra A, Grzegorzewski W (2000) Morphology of the dorsal nasal, frontal and facial veins in adult gilts. Folia Morphol 59: 179-191
Rekord w opracowaniu
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.