Long term treatment of ketogenic diet increases kidney tumor growth by p53-dependent manner

• Autorzy: Liskiewicz A. , Kasprowska-Liskiewicz D. , Lewin-Kowalik J. , Jedrzejowska-Szypulska H.
• Języki publikacji: EN

Abstrakty

EN

The Eker rat is a useful model of tuberous sclerosis, genetic disease with leads to tumor growth in many tissues. Ketogenic diet (KD) is already used in treatment of epilepsy in tuberous sclerosis patients, but its influence on tumor growth is still not clear. Here we reported how KD affects growth of kidney tumors in Eker rats, subjected to the diet for 4, 6 and 8 months. Data were compared to animals fed with standard diet. Obtained results showed that long term treatment of ketogenic diet promotes tumor growth in kidneys. Additionally, biochemical analysis of renal tissue indicate a possible mechanism in growth promoting influence of KD by lowering p53 protein, guardian of the genome.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.369

Twórcy

autor

Liskiewicz A.

• Department of Physiology, School of Medicine, Medical University of Silesia, Katowice, Poland

autor

Kasprowska-Liskiewicz D.

• Department of Pharmacology School of Medicine, Medical University of Silesia, Katowice, Poland

autor

Lewin-Kowalik J.

• Department of Physiology, School of Medicine, Medical University of Silesia, Katowice, Poland

autor

Jedrzejowska-Szypulska H.

• Department of Physiology, School of Medicine, Medical University of Silesia, Katowice, Poland