Anxiolytic and antidepressive effects of electric stimulation of the paleocerebellar cortex in pentylenetetrazol kindled rats

• Autorzy: Godlevsky L.S. , Muratova T. N. , Kresyun N. V. , van Luijtelaar G. , Coenen M. L.
• Języki publikacji: EN

Abstrakty

EN

Anxiety and depression are component of interictal behavioral deteriorations that occur as a consequence of kindling, a procedure to induce chronic epilepsy. The aim of this study was to evaluate the possible effects of electrical stimulation (ES) of paleocerebellar cortex on anxiety and depressive-like behavior in a PTZ kindled epilepsy model. Kindling was induced via pentylenetetrazol (PTZ) (25.0 mg/kg IP daily) during three weeks. Locomotion in open field, elevated plus-maze (EPM) and Porsolt forced swimming test have been used for the assessment of anxiety and depression-like behavior. ES (100 Hz) has been delivered to V-VII lobules of vermal cortex of kindled rats. ES of paleocerebellum reversed kindling-induced reduction of crossings of central squares, increased rearings, and decreased the number of defecations in open field. The duration that kindled animals spent in the open arms of the EPM increased in post- ES period, and the number of enterings into the closed arms of the EPM decreased. The duration of the immobility response in the swimming test in kindled rats was reduced after ESs of paleocerebellum. In all: ES of paleocerebellar structures suppressed anxious and depressive-like behavior in PTZ-kindled rats.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 4
• Opis fizyczny: p.456–464,fig.,ref.

Twórcy

autor

Godlevsky L.S.

• Department of Biophysics, Informatics and Medical Devices, Odessa National Medical University, Odessa, Ukraine

autor

Muratova T. N.

• Department of Biophysics, Informatics and Medical Devices, Odessa National Medical University, Odessa, Ukraine

autor

Kresyun N. V.

• Department of Biophysics, Informatics and Medical Devices, Odessa National Medical University, Odessa, Ukraine

autor

van Luijtelaar G.

• Biological Psychology, Donders Center for Cognition, Radboud University Nijmegen, Nijmegen, The Netherlands

autor

Coenen M. L.

• Biological Psychology, Donders Center for Cognition, Radboud University Nijmegen, Nijmegen, The Netherlands

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