Effects of forskolin on the longitudinal internal resistance (ri)in rabbit sinus node strips

• Autorzy: Tuganowski W. , Korczynska I. , Wasik K. , Wojcik B. , Bukowski M.
• Języki publikacji: EN

Abstrakty

EN

Tuganowski, W., Korczyńska, I., Wąsik, K., Wójcik В. and Bukowski, M.; Effects of forskolin on the longitudinal internal resistance (ri) in rabbit sinus node strips. Aclta physiol. pod., 1989, 40 (2): 164-170. The effect of several concentrations of 7-0-hemisucoinyl, 7-deacetyl forskolin on n was studied by means of microelectrode and single sucrose gap techniques. Twenity µmol·1⁻¹ of forskolin added ifco to the sucrose gap lowered ri 15% below the control value. The drug applied at 50 µmol·l⁻¹ initially decreased ri by 31%, and then it increased the resistance by 43% above the control, value. The possible mechanisms underlying these effects are discussed in terms of cAMP and Ca action on the cell coupling.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1989
• Tom: 40
• Numer: 2
• Opis fizyczny: p.164-170,fig.,ref.

Twórcy

autor

Tuganowski W.

• Department of Physiology, Silesian School of Medicine, Katowice, Poland

autor

Korczynska I.

• Department of Physiology, Silesian School of Medicine, Katowice, Poland

autor

Wasik K.

• Department of Physiology, Silesian School of Medicine, Katowice, Poland

autor

Wojcik B.

• Department of Physiology, Silesian School of Medicine, Katowice, Poland

autor

Bukowski M.

• Department of Physiology, Silesian School of Medicine, Katowice, Poland

Bibliografia

• 1. De Mello, W. С. (1975) Effect of intracellular injection of calcium and strontium on cell communication dm heart. J. Physiol. London 250. 231-245.
• 2. De Mello, W. C. (1984) Cell coupling and healing-over tin cardiac muscle. In Physiology and Pathophysiology of the Heart. Ed. N. Sperelakis, pp. 493-501, Nijhoff, The Hague.
• 3. De Mello, W. C. (1987) Cell-to-cell coupling assayed by means of electrical measurements. Experientia 43. 1075-1079.
• 4. De Mello, W. C., van Loon, P. (1987) Influence of cyclic nucleotides on junctional permeability in atrial muscle. J. Moll. Cell. Cardiol. 19. 83-94.
• 5. Imanaga, I. (1987) Cell-to-cell coupling studied by diffusional methods in myocardial cells. Experientia 43. 1080-1083.
• 6. Langer, G. A., Frank, J. S., Philipsem, K. D. (1982) Ultrastructure and calcium exchange of the sarcolemma, sarcoplasmic reticulum and mitochondria of the myocardium. Pharmac. Ther. 16. 331-376.
• 7. Noma, A., Tsuobi, N. (1987) Depedence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guinea-pig. J. Physiol. London 382. 193-211.
• 8. Peracchia, C., Girsh, S. J (1985) Fundtionaf modulation of cell icoupliing: evidence for a calmodulin-driven channel gate. Am. J. Physiol. 248. H765-H783.
• 9. Pressler, M. L. (1987) Effects of pCai and pHi on cell-to-cell coupling. Experientia 43. 1084-1091.
• 10. Rodbell, M. (1983) The complex structure and regulation of adenylate cyclase. In Regulatory Function of Adenosine. Eds. R. M. Berne, T. W. Rail, R. Rubio, pp. 3-17, Nijhoff, The Hague.
• 11. Saez, J, C., Spray, D. C., Naim, A. C., Hertzberg, E., Greengard, P., Bennett, M. V. L. (1986) cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. Proc. Natl. Acad. Sci. USA 83. 2473-2477.
• 12. Seamon, W. B., Daly, J. W. (1981) Forskolin: an unique diterpene activator of cyclic AMP-generating systems. J. Cyclic Nucleotide Res. 7. 201-211.
• 13. Tsien, R. W., Weingart, R. (1976) Inotropic effect of cyclic AMP in calf ventricular muscle studied by Cut end method. J. Physiol. London 260. 117-141.
• 14. Tuganowski, W., Kopeć, P. (1978) Effect of exogenous cAMP in the rabbit auricle. Pol. J. Pharmacol. Pharm. 30. 451-454.
• 15. Tuganowski, W., Kopeć, P., Tarnowski, W. (1981) Mechanism of intercellular synchronization in the rabbit sinus node. Experientia 37. 485-486.
• 16. Tuganowski, W., Bukowski, M., Korczyńska, I., Wójcik, В., Wąsik,K. (1986) A method of measurement of longitudinal resistances in an isolated cardiac and smooth muscle preparation. Pflügers Arch. 406. 232-233.
• 17. Weingart, R. (4986) Electrical properties of the nexal membrane studied in rat ventricular cell pairs. J. Physiol. London 370. 267-284.
• 18. Wojtczak, J. (1979) Contractures and increase of internal longitudinal resistance of cow ventricular muscle induced by hypoxia. Circulation Res. 44. 88-95.
• 19. Wojtczak, J. (1982) Influence of cyclic nucleotides on the internal longitudinal resistance and contractures in the normal and hypoxic mammalian cardiac muscle. J. Moll. Cell. Cardiol. 14. 259-265.