Myricetin blocks lipoteichoic acid - induced COX - 2 expression in human gingival fibroblasts

• Autorzy: Gutierrez-Venegas G. , Luna O. A. , Arreguin-Cano J. A. , Hernandez-Bermudez C.
• Języki publikacji: EN

Abstrakty

EN

Periodontitis is an infectious disease caused by microorganisms present in dental bacterial plaque. Lipoteichoic acid (LTA) is a component of the external membrane of Gram-positive bacteria. It causes septic shock. Ingested flavonoids have been reported to directly affect the regulation of cyclooxygenase-2 (COX-2) expression induced by bacterial toxins. In this study, we examined the effects of four flavonoids (luteolin, fisetin, morin and myricetin) on the activation of ERK1/2, p38 and AKT, and on the synthesis of COX-2 in human gingival fibroblasts treated with LTA from Streptococcus sanguinis. We found that luteolin and myricetin blocked AKT and p38 activation and that myricetin blocked LTA-induced COX-2 expression. The results of our study are important for elucidating the mechanism of action of flavonoid regulation of inflammatory responses.

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2014
• Tom: 19
• Numer: 1
• Opis fizyczny: p.126-139,fig.,ref.

Twórcy

autor

Gutierrez-Venegas G.

• Laboratorio de Bioquimica, Division de Estudios de Posgrado e Investigacion, Facultad de Odontologia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico

autor

Luna O. A.

• Laboratorio de Bioquimica, Division de Estudios de Posgrado e Investigacion, Facultad de Odontologia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico

autor

Arreguin-Cano J. A.

• Laboratorio de Bioquimica, Division de Estudios de Posgrado e Investigacion, Facultad de Odontologia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico

autor

Hernandez-Bermudez C.

• Laboratorio de Bioquimica, Division de Estudios de Posgrado e Investigacion, Facultad de Odontologia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico

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