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2017 | 73 | 10 |
Tytuł artykułu

Wide band-gap oxide nanoparticles as potential drug carriers

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Recent decades have brought rapid development in the field of nanotechnology, which has led to applications of nanoparticles in many industries. Unique properties of nanoparticles and their biocompatibility increase their potential as drug carriers in drug-delivery systems. Prof. Marek Godlewski’s team from the Institute of Physics PAS has developed wide band-gap metal oxide nanoparticles doped with rare-earth metals for applications as fluorescent markers. The potential of those nanoparticles to cross the closed gut barrier after alimentary application has prompted their use in drug delivery systems. In this study, we show that after conjugation with a model bioactive substance, lectin (Phaseolus vulgaris), these nanoparticles retained their advantageous properties and, following oral administration (10 mg/ml in RO, 0.3 ml/mouse), entered a variety of organs in the mouse model. Internal organs collected at key time points were analysed under a scanning cytometer and a confocal microscope. The results show that the conjugation reduced, but did not completely abolish, the capacity of nanoparticles to penetrate physiological barriers (intestinal, blood-brain barrier) in the organism.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
73
Numer
10
Opis fizyczny
p.657-660,fig.,ref.
Twórcy
autor
  • Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 100, 02-797 Warsaw, Poland
autor
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-766 Warsaw, Poland
  • Institute of Physics, Polish Academy of Sciences, Al.Lotnikow 32/46, 02-668 Warsaw, Poland
autor
  • Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 100, 02-797 Warsaw, Poland
autor
  • Institute of Physics, Polish Academy of Sciences, Al.Lotnikow 32/46, 02-668 Warsaw, Poland
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-766 Warsaw, Poland
Bibliografia
  • Godlewski M. M., Godlewski M.: Superradiant rare-earth doped nanocrystals in the study of persorption processes in the adult intestine, [in:] Méndez-Vilas A. (ed.): Current Microscopy Contributions to Advances in Science and Technology. Spain: Formatex 2012, p. 582-590.
  • Godlewski M. M., Kaszewski J., Szal A., Słońska A., Domino M. A., Mijowska E., Witkowski B. S., Godlewski M.: Size of nanocrystals affects their alimentary absorption in adult mice. Med. Weter. 2014, 70, 558-563.
  • Kaszewski J., Godlewski M. M., Witkowski B. S., Słońska A., Wolska-Kornio E., Wachnicki Ł., Przybylińska H., Kozankiewicz B., Szal A., Domino M. A., Mijowska E., Godlewski M.: Y2O3:Eu nanocrystals as biomarkers prepared by microwave hydrothermal method. Optical Materials 2016, 59, 157-164.
  • Kaszewski J., Witkowski B. S., Wachnicki Ł., Przybylińska H., Kozankiewicz B., Mijowska E., Godlewski M.: Reduction of Tb4+ ions in luminescent Y2O3:Tb nanorods prepared by microwave hydrothermal method. Journal of Rare Earths, 2016, Vol. 34, No. 8, p. 774.
  • Kiełbik P., Kaszewski J., Rosowska J., Wolska E., Witkowski B. S., Gralak M. A., Gajewski Z., Godlewski M., Godlewski M. M.: Biodegradation of the ZnO:Eu nanoparticles in the tissues of adult mouse after alimentary application. Nanomedicine: Nanotechnology, Biology, and Medicine 2016, doi: 10.1016/j.nano.2016.11.002.
  • Kielbik P., Kaszewski J., Witkowski B. S., Gajewski Z., Gralak M. A., Godlewski M., Godlewski M. M.: Cytometric analysis of Zn-based nanoparticles for biomedical applications, [in:] Méndez-Vilas A. (ed.): Microscopy and Imaging Science. Spain: Formatex 2017, p. 89-96.
  • Lohcharoenkal W., Wang L., Chen Y. C., Rojanasakul Y.: Protein nanoparticles as drug delivery carriers for cancer therapy. BioMed Research International 2014 vol. 2014.
  • Nitta S. K., Numata K.: Biopolymer-Based Nanoparticles for Drug/Gene Delivery and Tissue Engineering. Int. J. Mol. Sci. 2013, 14, 1629-1654.
  • Shu Y., Shu D., Haque F., Guo P.: Fabrication of pRNA nanoparticles to deliver therapeutic RNAs and bioactive compounds into tumor cells. Nat. Protoc. 2013, 8 (9).
  • Siafka P. I., Okur N. U., Karavas E., Bikiaris D. N.: Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: current status and uses. Int. J. Mol. Sci. 2016, 17, 1440.
  • Słońska A., Kaszewski J., Wolska-Kornio E., Witkowski B., Wachnicki Ł., Mijowska E., Karakitsou V., Gajewski Z., Godlewski M., Godlewski M. M.: Luminescent properties of ZrO2:Tb nanoparticles for applications in neuroscience. Optical Materials 2016, 59, 96-102.
  • Wolska E., Kaszewski J., Kiełbik P., Grzyb J., Godlewski M. M., Godlewski M.: Rare earth activated ZnO nanoparticles as biomarkers. Optical Materials 2014, 36, 1655-1659.
  • Yatsunenko S., Kaszewski J., Grzyb J., Pełech I., Godlewski M. M., Mijowska E., Narkiewicz U., Godlewski M.: Impact of yttria stabilization on Tb3+ intrashell luminescence efficiency in zirconium dioxide nanopowders. J. Phys.: Condens. Matter 2013, (25).
  • Zhang X.-F., Liu Z.-G., Shen W., Gurunathan S.: Silver nanoparticles: nynthesis, characterization, properties, applications, and therapeutic approaches. Int. J. Mol. Sci. 2016, 17, 1534.
  • Zhao Z., Li Y., Xie M.-B.: Silk fibroin-based nanoparticles for drug delivery. Int. J. Mol. Sci. 2015, 16, 4880-4903.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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