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2020 | 76 | 02 |
Tytuł artykułu

Histopathological picture of pancreatic islets in dogs with congenital portosystemic shunt

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Hypoglycemia is frequently found in dogs suffering from portosystemic shunt (PSS). However, the mechanisms leading to abnormal blood glucose concentration in such dogs have not been studied. Therefore, investigations were undertaken to study the structure of pancreatic islets in 25 patients with congenital PSS (cPSS). Material for morphometry and histopathology was taken during the surgical closing of the abnormal blood vessel. A total of 75 islets (3 randomly chosen from each patient) were analyzed, and their average size was compared to reference values for dogs that were considered as 50-325 μm. The average size of 47 (63%) islets was below 50 μm, whereas the mean dimension of the largest islet did not exceeded 80 μm. The average islet size in all patients was 46 (SD 13.3) μm and in only 2 dogs (8%) all 3 analyzed islets were bigger than the lower reference value. Histopathological examination revealed cytoplasmic vesicles in pancreatic cells, as well as extracellular, homogenous, acidophilic deposits in pancreatic islets. These results indicate that in dogs suffering from cPSS the pancreatic islets are smaller than the reference values and their cells may contain abnormal structures.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
76
Numer
02
Opis fizyczny
p.103-106,fig.,ref.
Twórcy
autor
  • Department of Small Animal Diseases with Clinic, Warsaw University of Life Sciences – SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland
autor
  • Department of Small Animal Diseases with Clinic, Warsaw University of Life Sciences – SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland
  • Department of Pathology and Veterinary Diagnostics, Warsaw University of Life Sciences – SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland
autor
  • Laboratory of Veterinary Epidemiology and Economics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences – SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland
autor
  • Department of Small Animal Diseases with Clinic, Warsaw University of Life Sciences – SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland
autor
  • Department of Small Animal Diseases with Clinic, Warsaw University of Life Sciences – SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland
Bibliografia
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  • Frymus J., Trębacz P., Degórska B., Sterna J., Kowalczyk P., Tomkowicz A., Galanty M.: Portosystemic shunt in dogs and cats. Current diagnostic aspects. Magazyn Wet. 2015, Nov., 12-22 (in Polish).
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  • Kraun M. B., Nelson L. L., Hauptman J. G., Nelson N. C.: Analysis of the relationship of extrahepatic portosystemic shunt morphology with clinical variables in dogs: 53 cases (2009-2012). J. Am. Vet. Med. Assoc. 2014, 245, 540-549.
  • Kruś S., Skrzypek-Fakhoury E. (ed): Patomorfologia kliniczna. PZWL, Warszawa 2007.
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  • Muranishi T., Takehana K., Hiratsuka T., Kobayashi A., Eerdunchaolu, Iwasa K., Abe M.: An investigation of the relationship between duct system and A cell-rich and PP cell-rich pancreatic islets in the canine pancreas. J. Vet. Med. Sci. 1999, 61, 737-742.
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  • Przybylik-Mazurek E., Pach D., Hubalewska-Dydejczyk A., Sowa-Staszczak A., Gilis-Januszewska A., Kulig J., Matyja A., Chrapczyński P.: Symptoms and early diagnostic possibilities of pancreatic endocrine cells hyperplasia (nesidioblastosis). Przegl. Lek. 2012, 69, 9-14 (in Polish).
  • Raffel A., Krausch M. M., Anlauf M., Wieben D., Braunstein S., Klöppel G., Röher H. D., Knoefel W. T.: Diffuse nesidioblastosis as a cause of hyperinsulinemic, hypoglycemia in adults: a diagnostic and therapeutic challenge. Surgery 2007, 141, 179-184.
  • Sobczak-Filipiak M., Męcik-Kronenberg T., Czopowicz M., Galanty M., Trębacz P., Frymus J., Badurek I., Szarek J.: Lipogranulomas and pigment granulomas in livers of dogs with portosystemic shunt. Pol. J. Vet. Sci. 2018, 21, 265-272.
  • Steiner D. J., Kim A., Miller K., Hara M.: Pancreatic islet plasticity: interspecies comparison of islet architecture and composition. Islets. 2010, 2, 135-145.
  • Tivers M. S., Handel I., Gow A. G., Lipscomb V. J.: Attenuation of congenital portosystemic shunt reduces inflammation in dogs. PLoS One. 2015, 10, 2, doi.org/10.1371/journal.pone.0117557.
  • Winnicka A.: Wartości referencyjne podstawowych badań laboratoryjnych w weterynarii. Wydawnictwo SGGW, Warszawa 2008, p. 55-56.
  • Woolcott O. O., Bergman R. N., Richey J. M., Kirkman E. L., Harrison L. N., Ionut V., Lottati M., Zheng D., Hsu I. R., Stefanovski D., Kabir M., Kim S. P., Catalano K. J., Chiu J. D., Chow R. H.: Simplified method to isolate highly pure canine pancreatic islets. Pancreas 2012, 41, 31-38.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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