Safety of honey consumed in Enugu State, Nigeria: a public health risk assessment of lead and polycyclic aromatic hydrocarbons

• Autorzy: Ozoani H.A. , Ezejiofor A.N. , Amadi C.N. , Chijioke-Nwauche I. , Orisakwe O.E.
• Języki publikacji: EN

Abstrakty

EN

Background: Information about lead (Pb) and polycyclic aromatic hydrocarbons (PAHs) concentrations in honey and their dietary intake is very important in human health risk assessment. Currently, there are paucity of data on the risk assessment and concentrations of lead and PAHs in honey in Nigeria. Objective: This study has determined the potential human health risk of lead and PAHs associated with the consumption of honey in Enugu state, Nigeria. Materials and methods: Lead and US EPA 16 priority PAHs in honey harvested from rural and urban communities in March 2016 were determined using Atomic Absorption Spectrometer and Gas Chromatograph respectively. Carcinogenic and non-carcinogenic risk assessments were carried. Results: The mean concentration of Pb in honey ranged from 0.005 mg/kg – 0.08 mg/kg. The mean concentrations of 16 PAHs in honey ranged from 4.71E-03 – 2.72 mg/kg. The dietary intake of the PAHs for adults and children ranged from 0.0021 – 0.0259 mg/kg/day and 0.0011 – 0.0129 mg/kg/day respectively. The levels of BaPeq and their margin of exposure MOE suggest non-significant health risk. The incremental life cancer risk ILCR of Pb were within safe range of <1E-04. Conclusion: Consumption of honey from Enugu State, Nigeria may not pose a significant health risk.

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 2020
• Tom: 71
• Numer: 1
• Opis fizyczny: p.57-66,ref.

Twórcy

autor

Ozoani H.A.

• Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria

autor

Ezejiofor A.N.

• Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria
• World Bank Africa, Centre of Excellence in Public Health and Toxicological Research (PUTOR), University of Port Harcourt, PMB,5323 Port Harcourt, Rivers State, Nigeria

autor

Amadi C.N.

• Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria

autor

Chijioke-Nwauche I.

• Department of Clinical Pharmacy, Faculty of Pharmacy, University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria

autor

Orisakwe O.E.

• Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria
• World Bank Africa, Centre of Excellence in Public Health and Toxicological Research (PUTOR), University of Port Harcourt, PMB,5323 Port Harcourt, Rivers State, Nigeria

Bibliografia

• 1. IARC. Polynuclear aromatic hydrocarbons. Part 1. Chemical, environmental and experimental data. IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 1983;3:1-453.
• 2. Scientific Committee on Food. Opinion of the Scientific Committee on Food and the risk to human health of Polycyclic Aromatic Hydrocarbon in food. SCF/CS/CNTM/PAH/29 Final 4 December 2002 [Online: https://ec.europa.eu/food/sites/food/files/safety/docs/sci-com_scf_out153_en.pdf
• 3. Ikeda M, Zhang ZW, Shimbo S, Nakatsuka H, Moon CS, Matsuda-Inoguchi N, Higashikawa K.: Urban population exposure to lead and Cadmium in east and south east Asia. Sci Total Environ.2000; 249 (1-3): 373-384.
• 4. Bede-Ojimadu O, Amadi CN Orisakwe OE.: Blood lead level in women of child-bearing age in subsaharan Africa: A systematic review. Front. Public Health, 19 December 2018; https://doi.org/10.3389/fpubh.2018.00367.
• 5. Anyanwu B, Ezejiofor A, Igweze Z.. Orisakwe OE.: Heavy Metals Mixture Exposure and effects in Developing Nations: An Update. Toxics. 2018;6(4):65. Available from: http://www.mdpi.com.
• 6. Türkdogan MK, Kilicel F, Kara K, Tuncer I, Uygan I.: Heavy metals in soil, vegetables and fruits in the endemic upper gastrointestinal cancer region of Turkey. Environ Toxicol Pharmacol. 2003;13(30):175-179.
• 7. Ioannidou MD, Zachariadis GA, Anthemidis AN, Stratis JA.: Direct determination of toxic trace metals in honey and sugars using inductively coupled plasma atomic emission spectrometry. Talanta 2005;65: 92–97.
• 8. Bogdanov S, Jurendic T, Sieber R, Gallmann P.: Honey for Nutrition and Health: A Review. Am J Coll Nutr. 2008;27: 677-689.
• 9. Sitarz-Palczak E, Kalembkiewicz J, Galas D.: Evaluation of the content of selected heavy metals in samples of Polish honeys. J. Ecol. Eng. 2015;16(3).
• 10. Costanza R, d’Arge R, De Groot R, Farber S, Grasso M, Hannon B, Limburg K, Naeem S,. O’neill RV, Paruelo J, Raskin RG.: The value of the world’s ecosystem services and natural capital. Nature 1997;87(6630):253.
• 11. Zhan X . Liang X, Jiang T, Xu G.: Interaction of phenanthrene and potassium uptake by wheat roots: a mechanistic model. BMC Plant Biol. 2013;13(1): 1–9.
• 12. Udowelle NA, Igweze ZN, Asomugha RN, Orisakwe OE.: Health Risk Assessment and Dietary Exposure to Polycyclic Aromatic Hydrocarbons (PAHs), Lead and Cadmium from Bread Consumed in Nigeria. Rocz Panstw Zakl Hig.2017;68(3): 269-280.
• 13. Orisakwe OE, Mbagwu HO, Ukpai P, Udowelle NA.: Survey of polycyclic aromatic hydrocarbons and lead in Chinese teas sold in Nigeria: levels and health implications. Rocz Panstw Zakl Hig 2015;66(3): 225-232.
• 14. Ekhator OC, Udowelle NA, Igbiri S, Asomugha RN, Igweze ZN, Orisakwe OE.: Safety Evaluation of Potential Toxic Metal Exposure from Street Food Consumed in Mid-West Nigeria. J. Environ. Public Health. January 2017;26;2:1-8. https://doi.org/10.1155/2017/8458057.
• 15. US-EPA IRIS United States, Environmental Protection Agency, Integrated Risk Information System. 2006. <http://www.epa. gov/iris/subst>.
• 16. WHO. Environmental Health Criteria 237. Principles for evaluating health risks in children associated with exposure to chemicals. Geneva, Switzerland: World Health Organization, 2006. whqlibdoc.who.int/publications/2006/924157237X_eng.pdf
• 17. Igbiri S, Udowelle NA, Ekhator OC, Asomugha RN, Igweze ZN, Orisakwe OE.: Edible Mushrooms from Niger Delta, Nigeria with Heavy Metal Levels of Public Health Concern: A Human Health Risk Assessment. Recent Pat Food Nutr Agric. 2018;9(1):31-41. Doi: 10.2174/2212798409666171129173802
• 18. Singh A, Sharma RK, Agrawal M, Marshall FM.: Risk assessment of heavy metal toxicity through contaminated vegetables from waste water irrigated area of Varanasi. India. Trop Ecol. 2010;51: 375–387.
• 19. US Environmental Protection Agency (US EPA). Supplemental Guidance for Developing soil Screening Levels for Superfund Sites,. Office of Solid Waste and Emergency Response; Washington, DC, USA, OSWER, 2001;9355: 4-24.
• 20. Ozoani HA.: Health risk assessment of some metals and polycyclic aromatic hydrocarbons in honey and other environmental matrices in Enugu State, Nigeria. MSc. dissertation, University of Port Harcourt, Nigeria, 2018.
• 21. Bamuwamye M, Ogwok P, Tumuhairwe V.: Cancer and non-cancer risks associated with heavy metal exposures from street foods: Evaluation of roasted meats in an urban setting. J. of Environ Poll and Human Health. 2015;3(2): 24-30.
• 22. Perugini M, Visciano P, Giammarino A, Manera M, Di Nardo W, Amorena M.:. Polycyclic aromatic hydrocarbons in marine organisms from the Adriatic Sea, Italy. Chemosphere 2007;66:1904-1910.
• 23. Nisbet ICT, LaGoy PK.: Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAH). Regul Toxicol Pharmacol 1993;16: 290-300.
• 24. EFSA. Scientific Committee Scientific Opinion on the applicability of the margin of exposure approach for the safety assessment of impurities which are both genotoxic and carcinogenic in substances added to food/feed. EFSA J. 2012;10(3): 2578.
• 25. EFSA, Scientific opinion of the panel on contaminants in the food chain on a request from the European Commission on polycyclic aromatic hydrocarbons in food. EFSA J. 2008;724: 1–114.
• 26. D´ıez S, Delgado S, Aguilera I.: Prenatal and early childhood exposure to mercury and methylmercury in Spain, a high-fish-consumer country. Arch. of Environ. Contam Toxicol. 2009; 56(3): 615–622.
• 27. Iwegbue CMA, Obi-Iyeke GE, Tesi GO, Obi G, Bassey FI.: Concentrations of selected metals in honey consumed in Nigeria. Int. J. Environ. Studies 2015;72(4) 713-722. DOI:10.1080/00207233.2015.1028783
• 28. Altun SK, Dinç H, Paksoy N, Temamoğulları FK, Savrunlu M.: Analyses of Mineral Content and Heavy Metal of Honey Samples from South and East Region of Turkey by Using ICP-MS. Int. J. Anal. Chem. 2017; Article ID 6391454, 6 pages,. https://doi.org/10.1155/2017/6391454
• 29. Kalia K, Flora SJS.: Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning. J. Occup. Health 2005;47:11-21. http://dx.doi.org/10.1539/joh.47.1
• 30. Martinello M, Dainese N, Manzinello C. Borin A.: Retrospective evaluation of lead contamination in honey from 2005 to present in northeastern Italy and future perspectives. Food Addit Contam. Part B. Survieillance 2016;9(3):1939-3229.
• 31. Llobet JM, Domingo JL, Bocio A, Casas C, Teixido A, Mu¨ ller L.: Human exposure to dioxins through the diet in Catalonia, Spain: carcinogenic and non-carcinogenic risk. Chemosphere 2003;50:1193–1200.
• 32. US Environmental Protection Agency (USEPA). Supplemental Guidance for Developing soil Screening Levels for Superfund Sites. Office of Solid Waste and Emergency Response; Washington, DC, USA, OSWER 2001;9355: 4-24.
• 33. Howsam M, Jones KC.: Sources of PAHs in the environment. In: Neilson AH (ed.) Handbook of environmental chemistry, PAHs and related compounds. Springer, Berlin, 1998; 3(1) :137–174.
• 34. Schoeny R, Poirier K.: Provisional guidance for quantitative risk assessment of polycyclic aromatic hydrocarbons, U.S. Environmental protection agency, office of research and development, Office of health and environmental assessment, Washington, DC,EPA/600/R-93/089(NTISPB94116571),2016. https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=49732.
• 35. Lemieux CL, Long AS, Lambert IB, Lundstedt S, Tysklind M, White PA.: Cancer risk assessment of polycyclic aromatic hydrocarbon contaminated soils determined using bioassay-derived levels of benzo[a] pyrene equivalents. Environ Sci Technol. 2015;49:179–805.
• 36. Wickramasinghe AP, Karunaratne DGGP, Sivakanesan R.: PM10-bound lung cancer risk of realistic different source scenarios, polycyclic aromatic hydrocarbons: Biological indicators, receptors and ‘source-exposure-effect relationship. Chemosphere 2012;87:1381–7.
• 37. Jolly YN, Islam A , Akbar S.: Transfer of metals from soil to vegetables and possible health risk assessment. Springerplus 2013;2: 385.
• 38. Bureau of Water Quality Program Guidance WPDES, Guidance Number: 3400-2015-01, Wisconsin Department of Natural Resources, 2015.
• 39. Ciemniak A, Witczak A Mocek K.: Assessment of trace element levels in Rhododendron honeys of Black Sea Region. Turkey J. Hazardous Materials 2013;156: 612–618.
• 40. Lister LJ, Svendsen C, Wright J,. Hooper HL, Spurgeon DJ.: Modelling the joint effects of a metal and a pesticide on reproduction and toxicokinetics in Lumbricid earthworms. Environ Int. 2011;37:663–670.
• 41. Calderon J, Ortiz-Perez D, Yanez L, Díaz-Barriga F.: Human exposure to metals. Pathways of exposure, biomarkers of effect, and host factors. Ecotoxicol Environ Saf. 2003 Sept;56(1): 93–103.
• 42. Alloway BJ.: Sources of heavy metals and metalloids in soils. Heavy metals in soils. Springer 2013; 11:50. DOI: 10.1007/978-94-007-4470-7_2.
• 43. Burdick AD, Davis JW, Liu KJ, Hudson LG, Shi H, Monske ML, Burchiel SW.: Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells. Cancer Research.;2003;632(2):7825-7833.

Identyfikatory

DOI

10.32394/rpzh.2020.0102