Effect of oral administration of zinc sulphate with simultaneous use of nonspecific immunostimulation on the course of trichophytosis in beef cattle

• Autorzy: Golynski M. , Lutnicki K. , Kostro K.
• Języki publikacji: EN

Abstrakty

EN

The paper assesses the treatment of cutaneous fungal infection in young beef cattle caused by Trichophyton verrucosum using orally administered zinc sulphate for 28 d at 2 g per animal per day and subcutaneous application of 2.5 mg/kg levamisole administered three times every 7 d. The study was conducted on animals at the age of 110 to 122 d, which were divided into two experimental groups: group I (animals suffering from ringworm with low levels of zinc in serum) and group II (animals suffering from ringworm with normal levels of zinc in serum). The remaining animals (control group) were divided into three subgroups: K (clinically healthy animals, which had normal serum levels of zinc), KI (animals infected with ringworm and showing a reduced level of zinc), and KII (animals suffering from ringworm with normal serum zinc levels). During the study the following parameters were investigated: clinical signs of fungal infection, zinc content in serum, percentage of phagocytic cells, and phagocytic index. The symptoms of the disease were observed only in group II on day 56. In group I, an increase in the percentage of phagocytic cells was observed, as compared to the original values, on days 7, 21, and 56 and a fall in this parameter was noted on days 14 and 28. In group II, there was a decrease on day 14 and an increase in comparison to the original values, followed by a gradual fall till day 56 of the experiment. In group I, phagocytic index remained on a stable level till day 56 and in group II until day 28, and subsequently began to increase gradually. It was found that oral supplementation of zinc sulphate combined with nonspecific immunostimulation may be applied in fighting skin fungal infection in cattle, and that zinc and levamisole may exhibit synergism affecting the evolution of nonspecific immunity.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2012
• Tom: 56
• Numer: 2
• Opis fizyczny: p.149-153,fig.,ref.

Twórcy

autor

Golynski M.

• Department and Clinic of Animal Internal Medicine,University of Life Science, 20-612 Lublin, Poland

autor

Lutnicki K.

autor

Kostro K.

Bibliografia

• 1. Bednarek D., Kondracki M.: Influence of zinc and magnesium on leukocytic system and alkaline phosphatase activity in calves. Medycyna Wet 1994, 50, 500-502.
• 2. Brunner C.J., Muscoplat C.C.: Immunomodulatory effects of levamisole. J Am Vet Med Assoc 1980, 176, 1159-1162.
• 3. Desplanter L.: Levamisole as an immunomodulator in the prevention of neonatal disease in newborn calves. 2nd Congress of EAVPT, Toulouse 1982, p. 99.
• 4. Gliński Z., Kostro K., Wołoszyn S.: Infectious diseases of animals. Part 2. Mycoses. Publ. AR, Lublin 2000.
• 5. Irwin M.R., Holmberg C.A., Knight H.D., Hjerpe C.A.: Effects of vaccination infectious bovine rhinotracheitis and simultaneous administration of levamisole on primaiy humoral responses in calves. Am J Vet Res 1976, 37, 223-226.
• 6. Krakowski L., Krzyżanowski J., Wrona Z., Siwicki A.K.: The effect of nonspecific immunostimulation of pregnant mares with 1,3/1,6 glucan and levamisole on the immunoglobulins levels in colostrum, selected indices of nonspecific cellular and humoral immunity in foals in neonatal and postnatal period. Vet Immunol Immunopathol 1999, 68, 1-11.
• 7. Ładosz J., Dąbska B.K.: Immunologic reactivity of rat lymphocytes in mixed cultures. Arch Immunol Ther Exp 1973, 16, 559-562.
• 8. Namazi M.: Zinc-levamisole combination: Powerful synergistic immunopotentiation? Med Hypotheses 2006, 66, 1253-1253.
• 9. Paulík Š., Slanina L., Dubaj J., Skotnický J., Gedeon V.: Phagocytosis in calves and its dynamics after experimental treatment. Vet Med 1987, 32, 93-104.
• 10. Renoux G., Renoux M.: Effet immunostimulant d'un imidazothiazole dans l'immunisation de la souris contre l'infection par Brucella abortus. C R Acad Sci Hebd Seances Acad Sci D 1971, 272, 349-350.
• 11. Stelletta C., Cuteri V., Bonizzi L., Frangipane di Regalbono A., Orsi F., Nisoli L., Lulla D., Morgante M.: Effect of levamisole administration on bluetongue vaccination in sheep. Vet Ital 2004, 40, 635-639.
• 12. Szczepanik M., Wilkołek P.: Selected parameters of nonspecific immunity in cattle suffering from trichophytosis at different levels of zinc in their serum. Medycyna Wet 2004, 60, 1233-1235.
• 13. Wawrzkiewicz K., Wawrzkiewicz J., Ziółkowska G.: Specific immunoprophylaxis of bovine ringworm with an inactivated combined vaccine. Medycyna Wet 1992, 48, 14-18.
• 14. Wiśniewski E.: The influence of zinc on weight gain of young cattle. Rev Farm 1973, 13-14, 10-12.
• 15. Wołoszyn S., Andrychiewicz J., Kostro K., Grądzki Z.: Studies on the occurrence and specific prevention of trychophytosis of breeding foxes. Medycyna Wet 1983, 39, 387-391.