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2010 | 56 | 3 |
Tytuł artykułu

Biochemical effects of aequous leaf extract of Abrus precatorius (Jecquirity bean) in Swiss albino mice

Treść / Zawartość
Warianty tytułu
PL
Działanie biochemiczne wodnego wyciągu z liści Abrus precatorius na myszy szczepu Swiss
Języki publikacji
EN
Abstrakty
EN
The leaf of Abrus precatorius has been used in Nigeria for the treatment of myriad of diseases including malaria, typhoid, cough, respiratory tract infections and hepatitis. Since the plant, especially the seeds, has been widely known to be toxic, there is a need to investigate biochemical and histopathological effect of aqueous extract of Abrus leaf in swiss albino mice. Biochemical analysis revealed significantly (p<0.05) increased aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine, urea, and chloride ion. There were also noted hypophosphataemia, hypokalaemia and hypoglycaemia (p<0.05). Histopathology revealed mononuclear cellular infiltrations of heart, lung, liver, intestine, spleen and kidney cells. Zenker’s necrosis of hepatocytes, thickening of interalveolar septae of pneumocytes and degeneration of splenic and kidney cells were observed as well. Hence aqueous extract of Abrus precatorius leaf is toxic at dose levels of 12.5, 25, 50, 100 and 200 mg/kg body weight when administered for a period of 21 days.
PL
Liście Abrus precatorius wykorzystywane są w Nigerii w leczeniu wielu chorób, m. in. malarii, duru brzusznego, kaszlu, infekcji dróg oddechowych oraz zapalenia wątroby. Ponieważ roślinę uznano za toksyczną, w szczególności jej nasiona, dlatego przeprowadzono badania mające na celu ocenę biochemicznego oraz histopatologicznego działania wodnego wyciągu z liści Abrus z wykorzystaniem myszy szczepu Swiss. W wyniku biochemicznych analiz stwierdzono statystycznie znamienny (p<0,05) wzrost aktywności aminotransferazy asparaginowej oraz alaninowej, fosfatazy alkalicznej, stężenia kreatyniny, mocznika i jonów chlorku. Odnotowano także hypofosfatemię, hypokaliemię oraz hypoglikemię (p<0,05). W wyniku przeprowadzonych badań histopatologicznych komórek jednojądrzastych wykryto nacieki w sercu, płucach, wątrobie, jelitach, śledzionie oraz nerkach. Ponadto zaobserwowano martwicę Zenkera hepatocytów, zgrubienie przegród między pęcherzykami płucnymi oraz degenerację komórek śledziony i nerek. Wykazano toksyczne działanie wodnego wyciągu z liści Abrus precatorius w dawkach 12,5, 25, 50, 100 oraz 200mg/kg masy ciała po podawaniu go przez 21 dni.
Słowa kluczowe
EN
Wydawca
-
Czasopismo
Rocznik
Tom
56
Numer
3
Opis fizyczny
p.63-80,fig.,ref.
Twórcy
  • Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, P.M.B.2373 Makurdi, Benue State, Nigeria
Bibliografia
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Bibliografia
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