Stress-free state of the red blood cell membrane and the deformation of its skeleton

• Autorzy: Svelc T. , Svetina S.
• Języki publikacji: EN

Abstrakty

EN

The response of a red blood cell (RBC) to deformation depends on its membrane, a composite of a lipid bilayer and a skeleton, which is a closed, twodimensional network of spectrin tetramers as its bonds. The deformation of the skeleton and its lateral redistribution are studied in terms of the RBC resting state for a fixed geometry of the RBC, partially aspirated into a micropipette. The geometry of the RBC skeleton in its initial state is taken to be either two concentric circles, a references biconcave shape or a sphere. It is assumed that in its initial state the skeleton is distributed laterally in a homogeneous manner with its bonds either unstressed, presenting its stress-free state, or prestressed. The lateral distribution was calculated using a variational calculation. It was assumed that the spectrin tetramer bonds exhibit a linear elasticity. The results showed a significant effect of the initial skeleton geometry on its lateral distribution in the deformed state. The proposed model is used to analyze the measurements of skeleton extension ratios by the method of applying two modes of RBC micropipette aspiration.

Słowa kluczowe

EN

stress-free shape; erythrocyte; membrane; deformation; membrane skeleton; skeleton deformation; spectrin; transmembrane protein

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2012
• Tom: 17
• Numer: 2
• Opis fizyczny: p.217-227,fig.,ref.

Twórcy

autor

Svelc T.

• Institute of Biophysics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

autor

Svetina S.

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