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2017 | 77 | Suppl.1 |
Tytuł artykułu

Orientation tuning in mouse primary visual cortex – Intrinsic signal optical imaging study

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
INTRODUCTION: Accumulating body of research has shown a cardinal bias for preference of spatially oriented targets in different species including humans, indicating greater neuronal responses in the primary visual cortex for horizontal or vertical contours in opposite to oblique ones. AIM(S): We used intrinsic signal optical imaging, a popular tool to map cortical function in rodents to verify the hypothesis whether a cardinal bias is present also in mouse primary visual cortex. METHOD(S): The experiments were performed on 7 week old wild mice under isoflurane anaesthesia. Intrinsic signals were recorded using CCD camera set above the visual cortex. Visual stimuli, square-wave black-and-white gratings (spatial frequency 0.05 cycle/degree, and temporal frequency 2 Hz, four orientations: 0, 45, 90, 135 degree) drifting in two directions, back and forth, were presented in random order with uniform grey images in 16 trials. Imaging was performed under the control of Imager 3001 system. Data were collected with 10 Hz resolution from 1 s before stimulus onset, during 7 s of visual stimulation and to 1 s after stimulus offset with 7 s interval between recordings. RESULTS: Using the described protocol of visual stimulation and data collection we could successfully map cortical responses to visual stimuli of different orientations. Collected images showed the strongest responses for horizontally and vertically oriented gratings. CONCLUSIONS: Our results support the hypothesis of the bias toward cardinal orientation preference in mouse visual cortex. FINANCIAL SUPPORT: Supported by the Polish National Science Center grant Symfonia 1 (2013/08/W/ NZ4/00691).
Słowa kluczowe
EN
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-
Rocznik
Tom
77
Numer
Opis fizyczny
p.82
Twórcy
  • Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
autor
  • Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
autor
  • Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
  • Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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