Experimental gentamicin-induced nephrotoxicity in the sheep

• Autorzy: Fartashvand M. , Mousavi G. , Hajisadeghi Y.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to investigate the nephrotoxic effects of gentamicin in adult male sheep, and to identify the earliest signs of toxicity and the extent of clinical and biochemical changes. Twenty clinically healthy yearling male Iranian fat- tailed sheep were injected with gentamicin sulfate at a daily dose of 80 mg/kg for 9-10 d when nephrotoxicosis was induced. Blood samples were collected weekly before and after induction of nephrotoxicosis. Gentamicin-induced nephrotoxicity was characterised by increased creatinine and urea levels in serum, electrolyte imbalances, occurrence of albuminuria, and renal dysfunction. Significant elevation in respiratory and heart rates were observed one week after treatment (P < 0.05). There was a noticeable increase in water consumption, lethargy , and loss of appetite in treated sheep. There were significant correlations between serum creatinine and potassium (P = 0.004, r = 0.759), sodium (P = 0.017, r = 0.501), and urea (P = 0.021, r = 0.617) levels. Additionally, significant negative correlations between serum total protein and albumin and creatinine (P = 0.023, r = -0.484) and urea (P = 0.036, r = -0.381) were found. At necropsy , the kidney s were pale, swollen, and wet on the cut surface, especially perirenal tissues and ureters were oedematous. These findings confirmed the previous reports in other species.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2014
• Tom: 58
• Numer: 4
• Opis fizyczny: p.657-661,fig.,ref.

Twórcy

autor

Fartashvand M.

• Department of Clinical Sciences, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, 5157944533 Tabriz, Iran

autor

Mousavi G.

• Department of Clinical Sciences, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, 5157944533 Tabriz, Iran

autor

Hajisadeghi Y.

• Department of Clinical Sciences, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, 5157944533 Tabriz, Iran

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