Embolic-thrombotic complications in dogs in the course of endotoxaemia

• Autorzy: Noszczyk-Nowak A. , Nowak M. , Paslawska U. , Nicpon J.
• Języki publikacji: EN

Abstrakty

EN

Results of supravital and post-mortem observation of embolic-thrombotic complications in dogs, in the course of endotoxaemia induced by pyometra and phlegmonous pneumonia due to infection with Psendomons aeruginosa, or endomyocarditis caused by Staphylococcus aureus infection were described. Multiorgan embolic-thrombotic complications were diagnosed in all presented cases. Most probably, the complications developed due to thrombocytopoenia secondary to platelet activation and exacerbation of endotoxin-induced DIC syndrome. In all the dogs, a disturbed cardiac rhythm was diagnosed supravitally. The rhythm disturbances might reflect myocardial injury due to presence of bacterial endotoxins in blood. The myocardial injury was confirmed by histopathological examination.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2012
• Tom: 56
• Numer: 1
• Opis fizyczny: p.69-74,fig.,ref.

Twórcy

autor

Noszczyk-Nowak A.

• Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats,Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland

autor

Nowak M.

autor

Paslawska U.

autor

Nicpon J.

Bibliografia

• 1. Danner R.L., Natanson C., Hosseini J.M., Banks S., MacVittie T.J., Parrillo J.E.: Pseudomonas aeruginosa compared with Escherichia coli produces less endotoxaemia but more cardiovascular dysfunction and mortality in canine model of septic shock. Chest 1990, 98, 1480-1487.
• 2. Hagman R., Lagerstedt A.-S., Fransson B.A., Bergstrom A., Haggstrom J.: Cardiac troponin I level in canine pyometra. Acta Vet Scand 2007, 49, 6-14.
• 3. Hagman R., Kindahl H., Lagerstedt A.-S.: Pyometra in bitches induces elevated plasma endotoxin and prostaglandin F₂ₐ metabolite levels. Acta Vet Scand 2006, 47, 55-68.
• 4. Myrvold H.E., Brandberg A.: Microembolism in experimental septic shock. Distribution of platelets and fibrinogen after intravenous injection of disintegrated Pseudomonas bacteria in dogs. Eur Surg Res 1977, 9, 34-47.
• 5. Myrvold H.E., Svalander C.: Pulmonary microembolism in early experimental septic shock: a morphological study in dogs. J Surg Res 1977, 23, 65-74.
• 6. Pelander L., Hagman R., Haggstrom J.: Concentrations of cardiac troponin I before and after ovariohysterectomy in 46 female dogs with pyometra. Acta Vet Scand 2008, 50, 35-42.
• 7. Patel K.N., Soubra S.H., Bellera R.V., Dong J.-F., McMullen C.A., Burns A.R., Rumbaut R.E.: Differential role of von Willebrand factor and P-selectin on microvascular thrombosis in endotoxaemia. Arterioscler Tromb Vase Biol 2008, 28, 2225-2230.
• 8. Tsuchiya R., Tatsuki Y., Kitao S., Furuichi M., Neo S., Hisasue M., Yamada T., Kobayashi K.: Characterization of canine platelet activation induced by platelet activation factor (PAF). J Vet Med Sci 2008, 70, 181- 183.
• 9. West R.L., Elovitz M.J., Hardway C.R.H.: Blood coagulation factor activity in experimental endotoxaemia. Ann Surg 1966, 163, 567-572.