Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia - induced acute lung injury

• Autorzy: Gokcinar D. , Ergin V. , Cumaoglu A. , Menevse A. , Aricioglu A.
• Języki publikacji: EN

Abstrakty

EN

Intravenous lipopolysaccharide (LPS) leads to acute lung injury (ALI) in rats. The purpose of this study was to examine the anti-inflammatory and antioxidant efficacy of ketamine, propofol, and ketofol in a rat model of ALI. We induced ALI in rats via intravenous injection of LPS (15 mg kg-1). The animals were randomly separated into five groups: control, LPS only, LPS + ketamine (10 mg·kg-1·h-1), LPS + propofol (10 mg·kg-1·h-1), LPS + ketofol (5 mg·kg-1·h-1 ketamine + 5 mg·kg-1·h-1 propofol). LPS resulted in an increase in the release of pro-inflammatory cytokines, mRNA expression related with inflammation, production of nitric oxide, and lipid peroxidation. Ketamine prevented the increase in markers of oxidative stress and inflammation mediators, both in plasma and lung tissue. Propofol decreased the levels of cytokines in plasma and lung tissue, whereas it had no effect on the IL-1-beta level in lung tissue. Ketamine downregulated mediators of lung tissue inflammation and reduced the level of circulating cytokines and protected lung tissue against lipid peroxidation. Ketofol decreased the level of TNF-α and IL-1β in plasma, as well as expression of cyclooxygenase-2 mRNA and the nitrate/nitrite level in lung tissue. The results of this investigation support the hypothesis that ketamine may be effective in preventing ALI.

Słowa kluczowe

EN

ketamine; propofol; ketofol; proinflammatory cytokine; oxidative stress; rat; animal model; endotoxemia; lung injury; lipopolysaccharide

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2013
• Tom: 60
• Numer: 3
• Opis fizyczny: p.451-456,fig.,ref.

Twórcy

autor

Gokcinar D.

• Department of Anesthesiology, Ankara Numune Training and Research Hospital, Ankara, Turkey

autor

Ergin V.

• Department of Medical Biology and Genetic, Faculty of Medicine, Gazi University, Ankara, Turkey

autor

Cumaoglu A.

• Department of Biochemistry, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey

autor

Menevse A.

• Department of Medical Biology and Genetic, Faculty of Medicine, Gazi University, Ankara, Turkey

autor

Aricioglu A.

• Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey

Bibliografia

• Ahmad N, Chen LC, Gordon MA (2002) Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia. J Leukoc Biol 71: 1005-1011.  
• Andolfatto G, Willman E (2010) A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol). Acad Emerg Med 17: 194-201. 
• Ang SF, Sio SW, Moochhala SM (2011) Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin e metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation. J Immunol 187: 4778-4787. 
• Baetz D, Shaw J, Kirshenbaum LA (2005) Nuclear factor-kappaB decoys suppress endotoxin-induced lung injury. Mol Pharmacol 67: 977-979. 
• Baeuerle PA (1998) IkappaB-NF-kappaB structures: at the interface of inflammation control. Cell 95: 729-731. 
• Barrientos-Vega R, Mar Sánchez-Soria M, Morales-García C, Robas-Gómez A, Cuena-Boy R, Ayensa-Rincon A (1997) Prolonged sedation of critically ill patients with midazolam or propofol: impact on weaning and costs. Crit Care Med 25: 33-40. 
• Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L et al. (1994) The American-European consensus conference on ARDS. Definitions, mechanisms, relevant outcomes and clinical trial coordination. Am J Respir Crit Care Med 149: 818-824. 
• Blackwell TS, Christman JW (1997) The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 17: 3-9. 
• Bone RC, Grodzin CJ, Balk RA (1997) Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 112: 235-243. 
• Brierley J, Peters MJ (2008) Distinct hemodynamic patterns of septic shock at presentation to pediatric intensive care. Pediatrics 122: 752-759. 
• Brigham KL, Meyrick B (1986) Endotoxin and lung injury. Am Rev Respir Dis 133: 913-927. 
• Callejas NA, Casado M, Díaz-Guerra MJ (2001) Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes. Hepatology 33: 860-867. 
• Chen RM, Chen TL, Lin YL, Chen TG, Tai YT (2005) Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells by down-regulating endothelial nitric oxide synthase expression and intracellular calcium levels. Crit Care Med 33: 1044-1049. 
• Chen TL, Chang CC, Lin YL, Ueng YF, Chen RM (2009) Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1 beta gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells. Toxicol Appl Pharmacol 240: 15-25. 
• Coates D, Prys-Roberts C, Spelina KR, Monk CR, Norley I (1985) Propofol ('Diprivan') by intravenous infusion with nitrous oxide: dose requirements and haemodynamic effects. Postgrad Med J 61: 76-79. 
• da Silva FC, do Carmo de Oliveira Cito M, da Silva MI (2010) Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice. Brain Res Bull 83: 9-15. 
• Gais P, Tiedje C, Altmayr F, Gaestel M, Weighardt H, Holzmann B (2010) TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. J Immunol 184: 5842-5848. 
• Gao J, Zeng B, Zhou L, Yuan S, Zhang S (2003) Therapeutic effect of propofol in the treatment of endotoxin-induced shock in rats. J Huazhong Univ Sci Technolog MedSci 23: 320-323. 
• Gao J, Zhao WX, Zhou LJ, Zeng BX, Yao SL, Liu D, Chen ZQ (2006) Protective effects of propofol on lipopolysaccharide-activated endothelial cell barrier dysfunction. Inflamm Res 55: 385-392. 
• Gocan NC, Scott JA, Tym LK (2000) Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle. Am J Physiol Heart Circ Physiol 278: H1480-H1489. 
• González-Correa JA, Cruz-Andreotti E, Arrebola MM (2008) Effects of propofol on the leukocyte nitric oxide pathway: in vitro and ex vivo studies in surgical patients. Naunyn Schmiedebergs Arch Pharmacol 376: 331-319. 
• Gragasin FS, Bourque SL, Davidge ST (2013) Propofol increases vascular relaxation in aging rats chronically treated with the angiotensin-converting enzyme inhibitor captopril. Anesth Analg 116: 775-783. 
• Huet O, Dupic L, Harrois A (2011) Oxidative stress and endothelial dysfunction during sepsis. Front Biosci 16: 1986-1995. 
• Inada T, Kubo K, Shingu K (2010) Promotion of interferon-gamma production by naturalkiller cells via suppression of murine peritoneal macrophage prostaglandin E2 production using intravenous anesthetic propofol. Int Immunopharmacol 10: 1200-1208. 
• Irifune M, Shimizu T, Nomoto M, Fukuda T (1992) Ketamine-induced anesthesia involves the N-methyl-d-aspartate receptor-channel complex in mice. Brain Res 596: 1-9. 
• James R, Glen JB (1980) Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agents. J Med Chem 23: 1350-1357. 
• Karin M, Delhase M (2000) The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol 12: 85-98. 
• Kawasaki T, Ogata M, Kawasaki C, Ogata J, Inoue Y, Shigematsu A (1999) Ketamine suppresses proinflammatory cytokine production in human whole blood in vitroi. Anesth Analg 89: 665-669. 
• Khutia KS, Mandal CM, Das S, Basu SR (2012) Intravenous infusion of ketamine-propofol can be an alternative to intravenous infusion of fentanyl-propofol for deep sedation and analgesia in peadiatric patients undergoing emergency short surgical procedures. Indian J Anaesth 56: 145-150. 
• Koga K, Ogata M, Takenaka I, Matsumoto T, Shigematsu A (1994) Ketamine suppresses tumor necrosis factor-alpha activity and mortality in carrageenan-sensitized endotoxin shock model. Circ Shock 44: 160-166. 
• Lappi-Blanco E, Kaarteenaho-Wiik R, Maasilta PK, Anttila S, Pääkkö P, Wolff HJ (2006) COX-2 is widely expressed in metaplastic epithelium in pulmonary fibrous disorders. Am J Clin Pathol 126: 717-724. 
• Larsen B, Hoff G, Wilhelm W, Buchinger H, Wanner GA, Bauer M (1998) Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood. Anesthesiology 89: 1218-1227. 
• Lasa M, Mahtani KR, Finch A, Brewer G, Saklatvala J, Clark AR (2000) Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol 20: 4265-4274. 
• Liu FL, Chen TL, Chen RM (2012) Mechanisms of ketamine-induced immunosuppression. Acta Anaesthesiol Taiwan 50: 172-177. 
• Liu YC, Chang AY, Tsai YC, Chan JY (2009) Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia. J Biomed Sci 16: 8. 
• Loh G, Dalen D (2007) Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department. Ann Pharmacother 41: 485-492. 
• Ma L, Wu XY, Zhang LH, Chen WM, Uchiyama A, Mashimo T, Fujino Y (2013) Propofol exerts anti-inflammatory effects in rats with lipopolysaccharide-induced acute lung injury by inhibition of CD14 and TLR4 expression. Braz J Med Biol Res 46: 299-305. 
• Marinelli WA, Ingbar DH (1994) Diagnosis and management of acute lung injury. Clin Chest Med 15: 517-146. 
• Min TJ, Kim WY, Jeong WJ, Choi HJ, Lee SY, Kim HJ, Park CY (2012) Effect of ketamine on intravenous patient-controlled analgesia using hydromorphone and ketorolac after the Nuss surgery in pediatric patients. Korean J Anesthesiol 62: 142-147. 
• Miranda KM, Espey MG, Wink DA (2001) A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5: 62-71. 
• Murphy PG, Myers DS, Davies MJ, Webster NR, Jones JG (1992) The antioxidant potential of propofol (2,6-diisopropylphenol). Br J Anaesth 68: 613-618. 
• Ogawa A, Uemura M, Kataoka Y, Ol K, Inokuchi T (1993) Effects of ketamine on cardiovascular responses mediated by N-methyl-D-aspartate receptor in the rat nucleus tractus solitarius. Anesthesiology 78: 163-167. 
• Okamoto I, Abe M, Shibata K (2000) Evaluating the role of inducible nitric oxide synthase using a novel and selective inducible nitric oxide synthase inhibitor in septic lung injury produced by cecal ligation and puncture. Am J Respir Crit Care Med 162: 716-722. 
• Randolph AG (2009) Management of acute lung injury and acute respiratory distress syndrome in children. Crit Care Med 37: 2448-2454. 
• Zhao W, Liu M, Kirkwood KL (0000) p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elements. J Biol Chem 283: 1778-1785.