Immunomodulatory activity of ethanolic leaf extract of Terminalia chebula

• Autorzy: Vadlamani S. , Bala Durga D.K.A. , Kumar B.V.
• Języki publikacji: EN

Abstrakty

EN

Terminalia chebula, a plant rich with phytochemicals, was selected in the present investigation for evaluating its immunomodulatory activities. Extract of the leaves were prepared in various solvents. Ethanolic extract was found to contain significant amount of phytochemicals. Hence, it was selected to study immunomodualtory activity. Silica gel column chromatography of ethanolic extract was performed. The fractions were further subjected to TLC and most active fractions were administrated to balb/C mice for evaluating immunomodulatory studies. Out of the five fraction (S1 – S5), S3 was found to possess immunostimulant activity. Provision of Ethanol Extracts of Terminalia chebula on balb/C mice can increase the antibody titers IgM and IgG.

Słowa kluczowe

EN

yellow myrobalan; Terminalia chebula; leaf extract; ethanol extract; phytochemical; immunostimulant; immunomodulatory activity; antibody titer

• Wydawca: -
• Czasopismo: International Letters of Natural Sciences
• Rocznik: 2015
• Tom: 47
• Opis fizyczny: p.82-88,fig.,ref.

Twórcy

autor

Vadlamani S.

• Department of Biotechnology, GITAM Institute of Science, GITAM University Visakhapatnam-530045, India

autor

Bala Durga D.K.A.

• Department of Biotechnology, GITAM Institute of Science, GITAM University Visakhapatnam-530045, India

autor

Kumar B.V.

• Department of Biotechnology, GITAM Institute of Science, GITAM University Visakhapatnam-530045, India

Bibliografia

• [1] Atal CK, Sharma ML, Khajuriya A (1986). Immunomodulating agents of plant origin 1 Preliminary Screening. J. Ethnopharmacol., 21: 41185- 192.
• [2] Patwardhan B, Kalbag D, Patki PS, Nagsampagi BA. Search of immunomodulatory agents: A review. Indian Drugs 1990; 28: 348-358.
• [3] U Ashok Kumar, C Manjunath, T Thaminzhmani, Y Ravi Kiran, Y Brahmaiah A Review on Immunomodulatory Activity Plants. Indian Journal of Novel Drug Delivery; 4(2), Apr-Jun, 2012, 93-103.
• [4] Owolabi J, Omogbai EKI & Obasuyi O. Antifungal and antibacterial activities of ethanolic and aqueous extract of Kigelia african (Bignoniaceae) stem bark. African Journal of Biotechnology 2007; 6(14): 882-85.
• [5] Lee, H. S.; Jung, S. H.; Yun, B. S.; Lee, K. W. (2006). "Isolation of chebulic acid from Terminalia chebula Retz. And its antioxidant effect in isolated rat hepatocytes". Archives of Toxicology81 (3): 211–218. doi:10.1007/s00204-006-0139-4. PMID 16932919
• [6] Kim TG, Kang SY, Jung KK, Kang JH, Lee E, Han HM and Kim SH. Antiviral activities of extracts isolated from Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq and Rheum palmatum L. against hepatitis B virus, Phytotherapy research. 2001; 15(8): 718-720.
• [7] Saleem, A.; Husheem, M.; Härkönen, P.; Pihlaja, K. (2002). "Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. Fruit". Journal of Ethnopharmacology 81 (3):327–336. doi:10.1016/S0378-8741(02)00099-5.
• [8] Bhuvaneswari S and Manivannan S. Antidiabetic and anti-inflammatory activity of Caralluma adscendens var. Adscendens; Int Journal of Pharma and Bio Sci, 2014; Vol-5 (1): P42-P49.
• [9] Suchalatha S, Devi CS; Protective effect of Terminalia chebula against lysosomal enzyme alterations in isoproterenol induced cardiac damage in rats. Experimental clinical cardiology, 2005; 10(2): 91-95.
• [10] Jagetia GC, Baliga MS, Malagi KJ, Sethukumar KM; The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to g-radiation. Phytomedicin, 2002; 9(2): 99–108.
• [11] Ravindran P, Babu KN, Sivaraman K. 2007. In: Turmeric: the genus Curcuma. Boca 150-155
• [12] Gupta AP, Gupta MM, Kuma SJ. 1999. Simultaneous determination of curcuminoids in curcuma samples using high-performance thin-layer chromatography. Liq Chromatogr Real Time 22:1561–9.
• [13] Odey M.O, Iwara I.A, Udiba U.U, 2Johnson J.T, Inekwe, U.V, 2Asenye M.E., Victor O. International Journal of Science and Technology Volume 1 No. 12, December, 2012 IJST © 2012 – IJST Publications UK. 688 Preparation of Plant Extracts from Indigenous Medicinal Plants
• [14] Abbot, D., & Andrews R.S. (1970). An Introduction to chromatography 2nd ed. Longman press, London, 72-78
• [15] S Revathy, S. Elumalai, Merina Benny and Benny Antony Isolation, Purification and identification of Curcuminoids from Turmeric (Curcuma longa L.) by Column Chromatography Journal of Experimental Sciences 2011, 2(7): 21-25
• [16] Stahl, E. (1969). TLC of Steroids and related compounds In: Thin layer Chromatography Hand book, 2nd ed. Springer-Verlag, Berlin, Heidelberg, New York.
• [17] Rao Y. Vasudeva, Govinda Rao Duddukuri, Babu G. Sunil and Rao R. Athota Immunomodulatory Activity of Achyranthes aspera on the Elicitation of Antigen-Specific Murine Antibody Response Pharmaceutical Biology 2002, Vol. 40, No. 03, pp. 175–178.

Identyfikatory

DOI

10.18052/www.scipress.com/ILNS.47.82