Side - effects of non - steroidal anti - inflammatory drugs on the liver in dogs and hepatoprotective effect of plant remedies

• Autorzy: Szweda M. , Szarek J. , Kielbowicz Z. , Szynaka B.
• Języki publikacji: EN

Abstrakty

EN

Hepatoprotective effect of plant drugs against hepatic tissue injury induced by non-steroidal anti-inflammatory drugs (NSAIDs) was assessed on Beagle dogs. The adverse effects of carprofen and robenacoxib on the hepatic tissue were evaluated on the basis of histopathological examination of liver sections. It was demonstrated that the use of NSAIDs with liquorice and composed plant remedy Pectosol® caused a reduction of hepatic adverse effects induced by the administration of NSAIDs. This fact indicates a hepatoprotective effect of the tested plant remedies during the treatment with NSAIDs. However, the results require further studies on a larger group of animals. Liquorice and Pectosol® reduce the hepatic side effects, which develop after the treatment with carprofen and, to a lesser extent, robenacoxib in young Beagles. Such studies allow to investigate the negative and positive effects of using robenacoxib and carprofen in dogs and, therefore, help to limit the NSAID-induced side effects on the liver in these animals.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2014
• Tom: 58
• Numer: 3
• Opis fizyczny: p.459-466,fig.,ref.

Twórcy

autor

Szweda M.

• Department of Pathophysiology, Forensic Veterinary Medicine and Administration, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

autor

Szarek J.

• Department of Pathophysiology, Forensic Veterinary Medicine and Administration, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

autor

Kielbowicz Z.

• Department of Surgery, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Szynaka B.

• Department of Medical Pathomorphology, Medical University of Bialystok, 15-269 Bialystok, Poland

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Identyfikatory

DOI

10.2478/bvip-2014-0070