Intravenous cocaine alters limphocyte subsets distribution in peripheral blood of rats

• Autorzy: Jankowski M. , Ignatowska-Jankowska B. , Glac W. , Swiergiel A.
• Języki publikacji: EN

Abstrakty

EN

Cocaine use has been associated with the increased risk for HIV and HCV infection in humans. The addicts have faster progression of HIV infection and increased incidence of AIDS suggesting that cocaine use results in a specifi c functional impairment of the immune system. Present study aimed to evaluate lymphocyte subsets number and distribution in peripheral blood after acute series of intravenous cocaine infusions. Adult male Wistar rats received 3 injections of cocaine hydrochloride (5 mg/kg/ml) in 30 min intervals. Blood samples were collected 30 min after the last infusion. Total leukocyte number, percentage numbers of leukocyte subpopulations and T, B, NK, T helper and T cytotoxic lymphocyte subsets were assessed. Intravenous cocaine caused signifi - cant decrease in total leukocyte and lymphocyte number and signifi cant fall in total numbers of T, B, NK and both T helper and T cytotoxic lymphocyte subsets. Furthermore, intravenous cocaine altered proportions between lymphocyte subsets by increasing T, mainly T helper and decreasing B, T cytotoxic and NK lymphocyte percentage portion. Immunosuppressive effect of intravenous cocaine infusions may thus be connected with alterations in lymphocyte subsets proportions. Such destabilization of lymphocyte subsets balance, especially T helper lymphocyte, could constitute basis of increased susceptibility for HIV and HCV infections.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.352-353

Twórcy

autor

Jankowski M.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Ignatowska-Jankowska B.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Glac W.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Swiergiel A.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland