Age-related effects of 5HT1A receptors activation on seroton

• Autorzy: Krotewicz M. , Strzelczuk M. , Krotewicz M.K.
• Języki publikacji: EN

Abstrakty

EN

BACKGROUND AND AIMS: Serotonin (5-HT) and its receptors are engaged in the regulation of the different brain functions. Pharmacological agents modifying central serotonin activity are effective in the treatment of brain dysfunctions. It has been also postulated that 5-HT is involved in the process of brain aging. The present study was designed to examine age-related effects of peripheral administration of 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), on serotonergic system activity in the brain of rats exposed to stressogenic conditions of transition test. METHODS: Regional brain concentration of 5-HT and 5-hydroxyindoleacetic acid of mature (12 months old) and aged (24 months old) rats exposed to transition test were examined using high performance liquid chromatography with electrochemical detection after ip administration of 8-OH-DPAT. Serotonin turnover was measured by 5-HIAA/5-HT ratio. RESULTS: We observed anxiolytic influence of 8-OH-DPAT administration in rats of both age (mature and aged). Peripheral administration of 8-OH-DPAT significantly decreased serotonin concentration in the brain regions of emotional-defensive system in mature rats. The serotonin turnover index was lower in the all studied brain regions of 12 months old animals. The results obtained for 24 months old rats were different. The administration of 8-OH-DPAT induced elevation of serotonin concentration while the analyzed turnover index was lower in the most studied brain regions of aged rats. CONCLUSIONS: The 5-HT1A receptors are postulated to be engaged in the emotional mechanisms, and above all in the fear/ anxiety mechanisms. The present study confirmed that hypothesis. Comparison of the behavioral data showed similar, independent of age, anxiolytic effect caused by administration of 5-HT1A receptor agonist. Simultaneously, the obtained data revealed age-related neurochemical differences after 5-HT1A receptors activation.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S94-S95

Twórcy

autor

Krotewicz M.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Strzelczuk M.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Krotewicz M.K.

• Independent Public Healthcare Centre in Garwolin, Garwolin, Poland