PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2010 | 70 | 1 |
Tytuł artykułu

Influence of dopaminergic and serotoninergic genes on working memory in healthy subjects

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Working memory is an ability to keep information in short-term memory and manipulate them “on line”. Working memory is also involved in complex frontal executive functions. The role of dopaminergic system in modulating working memory processes in prefrontal cortex is well established. Also the role of serotoninergic receptors is postulated. The purpose of this study was to assess the association between the polymorphisms of dopaminergic (DRD1, DRD3, DRD4, COMT) and serotoninergic (SERT – serotonin transporter, 5HT2A, 5HT2C) genes’ polymorphisms and performance on WCST in 200 volunteers from the Polish population. We found the association between DRD1, DRD4, COMT and SERT genes polymorphisms and the performance on WCST. The results obtained in the study indicate that dopaminergic and serotoninergic genes may play a role in modulating the executive function and working memory processes in healthy subjects. The pattern of this influence may be different in males and females. Moreover, the relationship between the efficacy of prefrontal cognitive function and genes polymorphisms may differ between healthy subjects and schizophrenic patients.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
70
Numer
1
Opis fizyczny
p.86-94,ref.
Twórcy
autor
  • Chair and Department of Clinical Neuropsychology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland
autor
  • Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
  • Chair and Department of Clinical Neuropsychology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland
  • Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
autor
  • Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
  • Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
autor
  • Chair and Department of Clinical Neuropsychology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland
Bibliografia
  • Alfimova MV, Golimbet VE, Gritsenko IK (2007) Interaction of dopamine system genes and cognitive functions in patients with schizophrenia and their relatives and in healthy subjects from general population. Neurosci Behav Phisiol 37: 643-650.
  • Arnsten AF, Li BM (2005) Neurobiology of executive func­tions: catecholamine influences on prefrontal cortical functions. Biol Psychiatry 57: 1377-1384.
  • Baddeley AD (2000) The episodic buffer: a new component of working memory. Trends Cogn Sci 4 : 417-423.
  • Barnett JH, Jones PB, Robbins TW, Müller U (2007a) Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry 12: 502-509.
  • Barnett JH, Heron J, Ring SM, Golding J, Goldman D, Xu K, Jones PB (2007b) Gender-specific effects of the cate- chol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children. Am J Psychiatry 164: 142-149.
  • Bilder RM, Volavka J, Czobor P, Malhotra AK, Kennedy JL, Ni X, Goldman RS, Hoptman MJ, Sheitman B, Lindenmayer JP, Citrome L, McEvoy JP, Kunz M, Chakos M, Cooper TB, Lieberman JA (2002) Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 52: 701-707.
  • Borg J, Henningsson S, Saijo T, Inoue M, Bah J, Westberg L, Lundberg J, Jovanovic H, Andrée B, Nordstrom AL, Halldin C, Eriksson E, Farde L (2009) Serotonin trans­porter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans. Int J Neuropsychopharmacol 12: 783-792.
  • Borkowska A, Rybakowski J (2001) Neuropsychological frontal lobe tests indicate that bipolar depressed patients are more impaired than unipolar. Bipolar Disord 3: 88-94.
  • Bosia M, Anselmetti S, Pirovano A, Ermoli E, Marino E, Bramanti P, Smeraldi E, Cavallaro R (2010) HTTLPR functional polymorphism in schizophrenia: Executive functions vs. sustained attention dissociation. Prog Neuropsychopharmacol Biol Psychiatry 34: 81-85.
  • Bruder G, Keilp J, Xu H, Shikman M, Schori E, Gorman J, Gilliam TC (2005) Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biol Psychiatry 58: 901-907.
  • Chen J, Lipska BK, Halim M, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR (2004) Functional analysis of genetic variation in catechol-O- metyltranserase (COMT): effects on mRNA, protein, and enzyme activity in post mortem human brain. Am J Hum Genet 75: 807-821
  • Cichon S, Nothen MM, Erdmann J, Propping P (1994) Detection of four polymorphic sites in the human dop- amine D1 receptor gene (DRD1). Hum Mol Genet 3: 209.
  • D'Esposito M, Postle BR, Rypma B (2000) Prefrontal corti­cal contribution to working memory: evidence from event-related fMRI studies. Exp Brain Res 133: 3-11.
  • Dean B (1996) Serotonin 2 receptors and the serotonin trans­porter in the schizophrenic brain. Behav Brain Res 73: 169-175.
  • Dean B, Hayes W (1996) Decreased frontal cortical sero- tonin2A receptors in schizophrenia. Schizophr Res 21: 133-139.
  • Diaz-Asper CM, Golberg TE, Kolachana BS Straub RE, Egan MF, Weinberger DR (2008) Genetic variation in catechol-O-metyltransferase: effects on working memory in schizophrenic patients, their sibilings, and healthy con­trols. Biol Psychiatry 63: 72-79.
  • Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD (2000) Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet 96: 56-60.
  • Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE (2001) Effect of COMT Val 108/158 Met phenotype on frontal lobe function and risk for schizophre­nia. Proc Natl Acad Sci U S A 98: 6917-6922.
  • Everett J, Lavoie K, Gagnon JF, Gosselin N (2001) Performance of patients with schizophrenia on the Wisconsin Card Sorting Test (WCST). J Psychiatry Neurosci 26: 123-130.
  • Fletcher PC, Henson RN (2001) Frontal lobes and human memory: insights from functional neuroimaging. Brain 124: 849-881.
  • Glahn DC, Bearden CE, Niendam TA, Escamilla MA (2004) The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder. Bipolar Disord 6: 171-182.
  • Gogos JA, Morgan M, Luine W, Santha M, Ogawa S, Pfaff D, Karayiorgou M (1998) Catechol-O-Methyltransferase- deficient mice exhibit sexually dismorphic changes in catecholamine levels and behaviour. Proc Natl Acad Sci U S A 95: 9991-9996.
  • Goldman-Rakic P (2000) D1 receptors in prefrontal cells and circuits. Brain Res Rev 31: 295-301.
  • Goldman-Rakic PS, Castner SA, Svensson TH, Siever LJ, Williams GV (2004) Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction. Psychopharmacology (Berl) 174: 3-16.
  • Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160: 636-645.
  • Harrison PJ, Tunbridge EM (2008) Catechol-O- methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology 33: 3037-3045.
  • Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtis G (1993) Wisconsin Card Sorting Test Manual: Revised and expanded. Psychological Assessment Resources, Odessa, FL.
  • Jonsson EG, Ivo R, Forslund K, Mattila-Evenden M, Rylander G, Cichon S, Propping P, Nothen MM, Asberg M, Sedvall GC (2001) No association between a pro­moter dopamine D(4) receptor gene variant and schizo­phrenia. Am J Med Genet 105: 525-528.
  • Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM (1996) Human catechol-O-methyl- transferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsy­chiatry disorders. Pharmacogenetics 6: 243-250.
  • Lannfelt L, Sokoloff P, Martres M, Pilon C, Giros B, Jonsson E, Sedvall G, Schwartz JC (1992) Amino-acid substitu­tion in the dopamine D3 receptor as a useful polymor­phism for investigating psychiatric disorders. Psychiatr Genet 2: 249-256.
  • Lappalainen J, Zhang L, Dean M, Oz M, Ozaki N, Yu DH, Virkkunen M, Weight F, Linnoila M, Goldman D (1995) Identification, expression, and pharmacology of a Cys23- Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). Genomics 27: 274-279.
  • Laszy J, Laszlovszky I, Gyertyan I (2005) Dopamine D3 recep­tor antagonists improve the learning performance in memo­ry-impaired rats. Psychopharmacology. 179: 567-575.
  • Lecrubier Y, Sheehan D, Weiller E, Amorim P, Bonora I, Sheehan K, Janavs J, Dunbar G (1997) The MINI International Neuropsychiatry Interview (M.I.N.I.) A
  • Short Diagnostic Structured Interview: Reliability and Validity According to the CIDI. European Psychiatry 12: 224-231.
  • Levesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P (1992) Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy- N,N-di-n-propyl-2-aminotetralin. Proc Natl Acad Sci U S A 89: 8155-8159.
  • Li T, Valllada H, Curtis D, Arranz M, Xu K, Cai G, Deng H, Liu J, Murray R, Liu X, Collier D (1996) Catechol-O- methyltransferase Val158Met polymorphism: frequency analysis in HanChinese subjects and allelic association of the low activity allele with bipolar affective disorder. Pharmacogenetics 7: 349-353.
  • Lundstrom K, Turpin M (1996) Proposed schizophrenia-re­lated gene polymorphism: expression of the Ser9Gly mutant human dopamine D3 receptor with the Semliki Forest virus system. Biochem Biophys Res Commun 225: 1068-1072.
  • Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T, Goldman D (2002) A functional polymorphism in the COMT gene and performance on a test of prefrontal cog­nition. Am J Psychiatry 159: 652-654.
  • McCann UD, Szabo Z, Vranesic M, Palermo M, Mathews WB, Ravert HT, Dannals RF, Ricaurte GA (2008) Positron emis­sion tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymetham- phetamine ("ecstasy") users: relationship to cognitive per­formance. Psychopharmacology (Berl) 200: 439-450.
  • McIntosh AM, Harrison LK, Forrester K, Lawrie SM, Johnstone EC (2005) Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives. Br J Psychiatry 186: 378-385.
  • Meneses A, Terron JA, Hong E (1997) Effects of the 5-HT receptor antagonists GR127935 (5-HT1B/1D) and MDL100907 (5-HT2A) in the consolidation of learning. Behav Brain Res 89: 217-223.
  • Meneses A (1999) Are 5-HT(1B/1D) and 5-HT(2A/2B/2C) receptors involved in learning and memory processes? IDrugs 2: 796-801.
  • Meyer-Lindenberg A, Nichols T, Callicott JH, Ding J, Kolachana B, Buckholtz J, Mattay VS, Egan M,
  • Weinberger DR (2006) Impact on complex genetic variation in COMT on human brain function. Mol Psychiatry 11: 867-877.
  • Miller SA, Dykes D, Plesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215.
  • Nocjar C (2002) Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience 111: 163-176.
  • Okuyama Y, Ishiguro H, Toru M, Arinami T (1999) A genet­ic polymorphism in the promoter region of DRD4 associ­ated with expression and schizophrenia. Biochem Biophys Res Commun 258: 292-295.
  • Olvera-Cortes ME, Anguiano-Rodriguez P, Lopez-Vazquez MA, Alfaro JM (2008) Serotonin/dopamine interaction in learning. Prog Brain Res 172: 567-602.
  • Raghanti MA, Stimpson CD, Marcinkiewicz JL, Erwin JM, Hof PR, Sherwood CC (2008) Differences in cortical serotonergic innervation among humans, chimpanzees, and macaque monkeys: a comparative study. Cereb Cortex 18: 584-597.
  • Rosa A, Peralta V, Cuesta MJ, Zarzuela A, Serrano F, Martinez-Larrea A, Fananas L (2004) New evidence of association between COMT gene and prefrontal neu- rocognitive function in healthy individuals from sibling pairs discordant for psychosis. Am J Psychiatry 161: 1110-1112.
  • Roth B (2004) Serotonin receptors represent highly favor­able molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology 174: 17-24.
  • Rybakowski JK, Borkowska A, Czerski PM Kapelski P, Dmitrzak-Weglarz M, Hauser J (2005) An association study of dopamine receptors polymorphisms and the Wisconsin Card Sorting Test in schizophrenia. J Neural Transm 112: 1575-1582.
  • Rybakowski JK, Borkowska A, Czerski PM, Dmitrzak- Weglarz M, Skibinska M, Kapelski P, Hauser J (2006) Performance on the Wisconsin Card Sorting Test in schizophrenia and genes of dopaminergic inactivation (COMT, DAT, NET). Psychiatry Res 143: 13-19.
  • Sambataro F, Reed JD, Murty VP, Das S, Tan HY, Callicott JH, Weinberger DR, Mattay VS (2009) Catechol-O- methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthood. Biol Psychiatry 66: 540-548.
  • Sazci A, Ergul E, Kucukali I, Kilic G, Kaya G, Kara I (2004) Catechol-O-Methyltransferase gene Val108/158Met poly­morphism and susceptibility to schizophrenia: association is more significant in woman. Brain Res 132: 51-56.
  • Seamans JK, Yang CR (2004) The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog Neurobiol 74: 1-58.
  • Stefanis NC, Van Os J, Avamopoulos D, Smyrnis M, Evdokimidis I, Hantoumi I, Stefanis CN (2004) Variation in catechol-O-methyltransferase val158met genotype associated with schizotypy: a population study of 543 young man. Biol Psychiatry 56: 510-515.
  • Stoltenberg SF, Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Zucker RA, Little KY (2002) Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in fami­lies with alcoholism. Am J Med Genet 114: 230-4.
  • Szekeres G, Keri S, Juhasz A (2004) Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymor­phism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet 124: 1-5.
  • Ugok A, Alpsan H, Cakir S, Saruhan-Direskeneli G (2007) Association of a serotonin receptor 2A gene polymor­phism with cognitive functions in patients with schizo­phrenia. Am J Med Genet B Neuropsychiatr Genet 144: 704-707.
  • van Kesteren RE, Spencer GE (2003) The role of neu- rotransmitters in neurite outgrowth and synapse forma­tion. Rev Neurosci 14: 217-231.
  • Wang X, Zhong P, Gu Z, Yan Z (2003) Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex. J Neurosci 23: 9852-9861.
  • Xu H, Kallendonk CB, Simpson EH, Keilp JG, Bruder GE, Polan HJ, Kandel ER, Gilliam TC (2007) DRD2 C957T polymorphism interacts with the COMT Val158Met poly­morphism in human working memory ability. Schizophr Res 90: 104-107.
  • Zalla T, Joyce C, Szoke A, Schurhoff F, Pillon B, Komano O, Perez-Diaz F, Bellivier F, Alter C, Dubois B, Rouillon F, Houde O, Leboyer M (2004) Executive dysfunctions as potential markers of familial vulnera­bility to bipolar disorder and schizophrenia. Psychiatry Res 121: 207-217.
  • Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (2004) Regulation of working memory by dopamine D4 receptor in rats. Neuropsychopharmacology 29: 1648-1655.
Uwagi
PL
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-c4dec4d7-2a99-43af-af01-30b2a6e5ed51
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.