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2006 | 66 | 1 |

Tytuł artykułu

Acute effects of maprotiline on learning, anxiety, activity and analgesia in male and female mice

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The acute effects of maprotiline (2.5, 5, 10, 15, 20 or 25 mg/kg) on learning, anxiety, activity and analgesia in male and female mice were evaluated. In addition to inhibitory avoidance learning, anxiety and locomotor activity were measured in the same animals using an elevated plus-maze. A study of the acute effects of maprotiline (15, 20 or 25 mg/kg) on analgesia was carried out in naive animals of both sexes. Maprotiline impaired inhibitory avoidance at doses of 15, 20 or 25 mg/kg. The highest dose produced an anxiolytic effect in females, and the doses of 20 and 25 mg/kg reduced locomotor activity. Analgesia was observed with the highest dose. The impairment of inhibitory avoidance by maprotiline would seem to be independent of the drugÂ’s influence on anxiety, is not shadowed by an instrumental performance deficit and, at least in the case of the highest dose, could be influenced by the drugÂ’s effects on analgesia. It is hypothesized that acquisition is the memory process principally affected by maprotiline, and in particular stimuli processing. The lack of sex differences in the effects of maprotiline on inhibitory avoidance supports the generalization of findings previously obtained only in males.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

66

Numer

1

Opis fizyczny

p.23-31,fig.,ref.

Twórcy

  • Department of Psychobiology, University of Valencia, Blasco Ibanez 21, E-46010 Valencia, Spain
autor
  • Department of Psychobiology, University of Valencia, Blasco Ibanez 21, E-46010 Valencia, Spain
autor
  • Department of Psychobiology, University of Valencia, Blasco Ibanez 21, E-46010 Valencia, Spain
autor
  • Department of Psychobiology, University of Valencia, Blasco Ibanez 21, E-46010 Valencia, Spain
autor
  • Department of Psychobiology, University of Valencia, Blasco Ibanez 21, E-46010 Valencia, Spain

Bibliografia

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-c44fb2ac-1b66-439e-bc11-44975bc892a6
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