Expression of Cyclooxygenase - 2 in naturally occurring bovine cutaneous fibropapillomas

• Autorzy: Bocaneti F. , Altamura G. , Corteggio A. , Solcan C. , Valescu E. , Borzacchiello G.
• Języki publikacji: EN

Abstrakty

EN

Bovine cutaneous fibropapillomas are benign skin tumours characterized by epithelial and dermal proliferation and induced by Bovine papillomaviruses (BPVs). Cyclooxygenase (COX) 1 and 2 are enzymes involved in pathological conditions, such as inflammation and epithelial carcinogenesis. Here we investigated biochemically and immunohistochemically COX-2 expression in bovine cutaneous fibropapillomas. Eight of twelve fibropapillomas (67%) showed COX-2 positive immunosignal mostly in the cytoplasm of the basal cell layer, while the normal skin did not stain. Biochemical analysis confirmed the expression of COX-2 in tumour samples. This study shows COX-2 expression in cutaneous fibropapillomas, suggesting a contribution in epithelial tumour development.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2015
• Tom: 18
• Numer: 3
• Opis fizyczny: p.655-658,fig.,ref.

Twórcy

autor

Bocaneti F.

• Department of Public Health, Faculty of Veterinary Medicine, University of Agriculture Sciences and Veterinary Medicine, Ion Ionescu de la Brad, Iasi, Romania

autor

Altamura G.

• Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino, 1 80137 Napoli, Italy

autor

Corteggio A.

• Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino, 1 80137 Napoli, Italy

autor

Solcan C.

• Department of Public Health, Faculty of Veterinary Medicine, University of Agriculture Sciences and Veterinary Medicine, Ion Ionescu de la Brad, Iasi, Romania

autor

Valescu E.

• Department of Public Health, Faculty of Veterinary Medicine, University of Agriculture Sciences and Veterinary Medicine, Ion Ionescu de la Brad, Iasi, Romania

autor

Borzacchiello G.

• Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino, 1 80137 Napoli, Italy

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Identyfikatory

DOI

10.1515/pjvs-2015-0084