The FORMIN 2 protein is required for the remodeling of consolidated memories

• Autorzy: Sananbenesi F. , Pinhero P. , Rebola N. , Kerimoglu C. , Burkhardt S. , Rizzoli S. , Mulle C. , Fischer A.
• Języki publikacji: EN

Abstrakty

EN

The brain has a remarkable capacity to undergo plasticity changes that are believed to underlie the acquisition, consolidation and maintenance of memory traces. To identify the molecular and cellular substrates of cognitive function is a major aim of modern neuroscience. A critical mechanism that has been implicated with neuronal plasticity is the regulation of the actin cytoskeleton. Thus, we study the role of FORMIN 2 (FMN2), a protein that regulates actin dynamics, in the adult brain of mice. Fmn2-/- mice can normally form hippocampus-dependent associative and spatial memories but display a severe failure in adapting a once acquired memory. Thus, Fmn2-/- mice show dramatic impairments in reversal learning paradigms. On the molecular and cellular levels this phenotype is explained by deregulated actin dynamics in the hippocampal striatum lucidum linked to a reduced number of synaptic vesicles per active zone and led to specific changes in the physiology of mossy fiber-CA3 synapses. Our data indicates that FMN2 at the mossy fiber-CA3 synapse is required for the fine-tuning of hippocampal memory traces.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: S
• Opis fizyczny: p.24

Twórcy

autor

Sananbenesi F.

• Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Goettingen, Germany

autor

Pinhero P.

• CNRS UMR 5091, Institut Francois Magendie, Universite Bordeaux 2, Bordeaux, France

autor

Rebola N.

• CNRS UMR 5091, Institut Francois Magendie, Universite Bordeaux 2, Bordeaux, France

autor

Kerimoglu C.

• Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Goettingen, Germany

autor

Burkhardt S.

• Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Goettingen, Germany

autor

Rizzoli S.

• STED Microscopy of Synaptic Function, European Neuroscience Institute, Goettingen, Germany

autor

Mulle C.

• CNRS UMR 5091, Institut Francois Magendie, Universite Bordeaux 2, Bordeaux, France

autor

Fischer A.

• Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Goettingen, Germany

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