Possible neural compenasatory mechanisms for the communication between the nervous and immune systems after cyclooxygenase inhibition

• Autorzy: Kobrzycka A. , Wieczorek M. , Zubel J. , Oclon E. , Hubner M.
• Języki publikacji: EN

Abstrakty

EN

BACKGROUNDANDAIMS: The phenomenon of communication between the nervous and immune systems is commonly accepted. There were postulated several pathways for information exchange between these two systems, among them: neuronal with the vagus nerve, and enzymatic exercised through cyclooxygenases. The fact of biological compensation of many processes in our organisms is well known. In our project we hypothesized the existence of such phenomenon is situation of affected pathway for transferring of immune signal from the periphery to the brain after inhibition of cyclooxygenases. METHODS: To investigate the existence of these mechanisms, neurochemical changes occurring in the hypothalamus (the initial section of the stress axis – HPA) after intraperitoneal administration of LPS (10 mcg/animal) were analyzed. We studied the effect of long-term (10 days) administration of cyclooxygenases inhibitors on the neurochemical changes in the activity of the hypothalamus in response to LPS or saline ip administration. The rats were subcutaneously injected with selective cyclooxygenases inhibitors; Celecoxib (10 mg/kg) and SC-560 (3 mg/kg), respectively. RESULTS: Future HPLC analysis shown an increased activity of the noradrenergic and serotonergic systems within the hypothalamus. These data are comparable with those obtained after saline injections. CONCLUSIONS: These results suggest the presence of compensatory mechanisms responsible for the stimulation of the HPA axis after peripherally immune challenges. They also suggest that longterm intake of non-steroidal anti-inflammatory drugs may not affect, or in a very minor degree, the relationships between the immune and the nervous systems. Supported by NCN: UMO-2012/07/B/NZ4/00205.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S47

Twórcy

autor

Kobrzycka A.

• Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland

autor

Wieczorek M.

• Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland

autor

Zubel J.

• Animals Physiology and Endocrinology, Agriculture University, Krakow, Poland

autor

Oclon E.

• Animals Physiology and Endocrinology, Agriculture University, Krakow, Poland

autor

Hubner M.

• Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland