Cell-type specific regulation of morphine-and glucocorticoid induced genes

• Autorzy: Slezak M. , Bielecki W. , Gieryk A. , Solecki W. , Kubik J. , Przewlocki R.
• Języki publikacji: EN

Abstrakty

EN

Single morphine administration to mice leads to changes in the expression of numerous genes in mouse striatum. Among them are genes regulated by the glucocorticoid receptor activation, like Sgk1, Gilz and Plzf [Korostynski et al. (2007) Genome Biol]. Analysis of their expression patterns with the use of in situ hybridization revealed their different regional distribution throughout the brain. To verify the cellular specifi city of expression, the double immunohistochemical stainings were performed with antibodies directed against investigated proteins and cellular markers (NeuN, GFAP, CC1, OX42). The results show that certain morphine- and GR-induced proteins are expressed in neurons, whereas others in glial cells. Hence, their regulation depends on the cell-type specifi c context.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.340

Twórcy

autor

Slezak M.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Bielecki W.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Gieryk A.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Solecki W.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Kubik J.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Przewlocki R.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland