The neural correlates of specific executive dysfunctions in Parkinson’s disease

• Autorzy: Gawrys L. , Falkiewicz M. , Pilacinski A. , Riegel M. , Piatkowska-Janko E. , Bogorodzki P. , Wolak T. , Andrysiak R. , Krolicki L. , Kulinski R. , Koziorowski D. , Janik P. , Rymarczyk K. , Grabowska A. , Kaczmarek L. , Szatkowska I.
• Języki publikacji: EN

Abstrakty

EN

Several functional neuroimaging studies in patients with Parkinson's disease (PD) have suggested that changes in the fronto-parietal-striatal networks are associated with deficits in executive functioning. However, executive functions (EF) are multifaceted and include three dissociable components: working memory, response inhibition, and task-switching. This study investigated which component of executive functioning is most strongly associated with fronto-parietal-striatal efficiency in PD. PD patients (with and without executive dysfunction), and age-matched healthy subjects, completed a battery of cognitive tests previously shown to discriminate among the three EF components. Principal component analysis conducted on the selected cognitive test variables yielded three expected EF components. The component scores were used in regression analysis to assess the relationship between the EF efficiency and blood oxygenation level-dependent (BOLD) signal related to performing the n-back, an experimental task that draws upon multiple components of executive functioning: working memory, response inhibition, and task-switching. We found distinct neural correlates of specific executive dysfunctions in patients with PD. However, all of them seem to be associated with fronto-parietal-striatal efficiency.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 4
• Opis fizyczny: p.465–478,fig.,ref.

Twórcy

autor

Gawrys L.

• Second Department of Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Falkiewicz M.

• Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland

autor

Pilacinski A.

• Hertie Institute for Clinical Brain Research, Tuebingen, Germany

autor

Riegel M.

• Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Warsaw, Poland

autor

Piatkowska-Janko E.

• Institute of Radioelectronics, Warsaw University of Technology, Warsaw, Poland

autor

Bogorodzki P.

• Institute of Radioelectronics, Warsaw University of Technology, Warsaw, Poland

autor

Wolak T.

• Institute of Physiology and Pathology of Hearing, Warsaw, Poland

autor

Andrysiak R.

• Department of Nuclear Medicine, Warsaw Medical University, Warsaw, Poland

autor

Krolicki L.

• Department of Nuclear Medicine, Warsaw Medical University, Warsaw, Poland

autor

Kulinski R.

• Department of Nuclear Medicine, Warsaw Medical University, Warsaw, Poland

autor

Koziorowski D.

• Department of Neurology, Faculty of Heath Science, Medical University of Warsaw, Warsaw, Poland

autor

Janik P.

• Department of Neurology, Medical University of Warsaw, Warsaw, Poland

autor

Rymarczyk K.

• Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland

autor

Grabowska A.

• Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland

autor

Kaczmarek L.

• Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Warsaw, Poland

autor

Szatkowska I.

• Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland

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