New hippocampal neurons are not obligatory for memory formation:mice with no adult brain neurogenesis show learning

• Autorzy: Jaholkowski P. , Kiryk A. , Jedynak P. , Ben Abdallah N. , Knapska E. , Kowalczyk A. , Piechal A. , Blacharz-Klin K. , Widy-Tyszkiewicz E. , Wilczynski G. , Lipp H. , Kaczmarek L. , Filipkowski R.
• Języki publikacji: EN

Abstrakty

EN

New neurons are produced in the brains of adult animals, including humans, throughout the lifespan. Since one of the site of adult brain neurogenesis is the hippocampal formation, a brain structure involved in learning and memory, new neurons were expected to be involved in these phenomena. However, the very evidence supporting this hypothesis remains limited, inconsistent and in most cases indirect. Also, the experiments in which adult neurogenesis is blocked use irradiation and drugs known for their side effects. We used a novel approach, cyclin D2 knock-out mice (D2 KO mice), specifi cally lacking adult brain neurogenesis (which was verifi ed using DCX and NeuN staining) to verify its importance in learning and memory. D2 KO mice and their wild type siblings were tested in several behavioral paradigms including those in which the role of adult neurogenesis has been postulated. D2 KO mice showed no impairment in sensorimotor tests with only sensory impairment in an olfaction-dependent task. However, D2 KO mice showed proper procedural learning as well as learning in context (including remote memory), cue and trace fear-conditioning, Morris water maze, novel object recognition test, and in a multifunctional behavioral system – Intellicages. Our results suggest that adult brain neurogenesis is not obligatory in learning, including the kinds of learning where the role of adult neurogenesis has previously been strongly suggested. Support – MNiSW grant no N303 051 31/1624.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.371

Twórcy

autor

Jaholkowski P.

• Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Kiryk A.

• Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Jedynak P.

• Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Ben Abdallah N.

• Department of Neuroanatomy and Behavior, Anatomy Institute, university of Zurich, Zurich, Switzerland

autor

Knapska E.

• Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Kowalczyk A.

• Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Piechal A.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Blacharz-Klin K.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Widy-Tyszkiewicz E.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Wilczynski G.

• Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Lipp H.

• Department of Neuroanatomy and Behavior, Anatomy Institute, university of Zurich, Zurich, Switzerland

autor

Kaczmarek L.

• Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Filipkowski R.

• Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland