Human dirofilariasis due to Dirofilaria repens in Ukraine, an emergent zoonosis: epidemiological report of 1465 cases

• Autorzy: Salamatin R.V. , Pavlikovska T. M. , Sagach O. S. , Nikolayenko S. M. , Kornyushin V. V. , Kharchenko V. O. , Masny A. , Cielecka D. , Konieczna-Salamatin J. , Conn D. B. , Golab E.
• Języki publikacji: EN

Abstrakty

EN

The filarial nematode Dirofilaria repens is currently considered to be one of the most extensively spreading human and animal parasites in Europe. In Ukraine, reporting cases of dirofilariasis has been mandatory since 1975, and the disease was included in the national surveillance system for notifiable diseases. Up until December 31st 2012, a total of 1533 cases have been registered, with 1465 cases occurring within the previous 16 years. Most of the cases of dirofilariasis were registered in 6 regions: Kyiv, and the Donetsk, Zaporizhzhya, Dnipropetrovsk, Kherson and Chernihiv oblasts. In the years 1997–2002 the highest incidence rate was noted in the Kherson oblast in the south of the country (9.79 per 100 000 people), and the lowest in western Ukraine (0.07–1.68 per 100 000 people). D. repens infections were registered in all oblasts. Parasitic lesions were most often located in the head, the subconjunctival tissue and around the eyes. D. repens lesions were also found in the limbs, torso, male sexual organs, and female mammary glands. Dirofilariasis was diagnosed in persons aged from 11 months to 90 years old, most often among people between 21–40 years of age. Most patients had only one parasitic skin lesion; the majority of isolated nematodes were female. The results of our analysis point to a constant increase in D. repens dirofilariasis incidence in humans in Ukraine. Despite educational efforts, infections have become more frequent and the territory in which the disease occurs has enlarged to encompass the whole of Ukraine. Nevertheless, the Ukrainian sanitary-epidemiological services managed to achieve some measure of success, e.g. by creating a registration system for D. repens infections and establishing proper diagnostics for the disease.

Słowa kluczowe

EN

dirofilariasis; Dirofilaria repens; filarial nematode; nematode; zoonosis; epidemiology; human infection; Ukraine

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 2013
• Tom: 58
• Numer: 4
• Opis fizyczny: p.592-598,fig.,ref.

Twórcy

autor

Salamatin R.V.

• Department of General Biology and Parasitology, Medical University of Warsaw, Warsaw, Poland

autor

Pavlikovska T. M.

• Center of Diseases Control and Monitoring of the Ministry of Health of Ukraine, Kyiv, Ukraine

autor

Sagach O. S.

• Center of Diseases Control and Monitoring of the Ministry of Health of Ukraine, Kyiv, Ukraine

autor

Nikolayenko S. M.

• Center of Diseases Control and Monitoring of the Ministry of Health of Ukraine, Kyiv, Ukraine

autor

Kornyushin V. V.

• I.I. Schmalhausen Institute of Zoology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

autor

Kharchenko V. O.

• I.I. Schmalhausen Institute of Zoology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

autor

Masny A.

• Department of Medical Parasitology, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland

autor

Cielecka D.

• Department of Medical Parasitology, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland

autor

Konieczna-Salamatin J.

• Institute of Sociology, University of Warsaw, Warsaw, Poland

autor

Conn D. B.

• Department of Biology and One Health Center, Berry College, Mount Berry, GA, USA

autor

Golab E.

• Department of Medical Parasitology, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland

Bibliografia

• Anonymous. 1975. [Clinical cases of dirofilariasis in humans]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 44, 616 (In Russian). PMid: 1219362.
• Babal P., Kobzova D., Novak I., Dubinsky P., Jalili N. 2008. First case of cutaneous human dirofilariosis in Slovak Republic. Bratislavské Lekárske Listy, 109, 486–488. PMid: 19205556.
• Babes V. 1879. Ueber einen neuen Parasiten des Menschen. Medizinisch-chirurgisches Centralblatt, 14, 554.
• Babesiu V. 1880. Ueber einen im menschlichen Peritonäum gefundenen Nematoden. Archiv für pathologische Anatomie und Physiologie und für klinische Medicin, 81, 158–165.
• Babìčenko V.M., Guŝina L.M., Kozel S.V., Nìkolaêva N.V., Rudššina S.F. 2007. Air temperature (July). In: (Ed. L. G. Rudenko) Nacìonalńij Atlas Ukraïni, Kyiv, Kartografìa, p. 167 (In Ukrainian).
• Bolgarenko A.V. 2001. [Human dirofilariasis in the Nikolaev region]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 3, 57–58 (In Russian). PMid: 11680379.
• Cielecka D., Żarnowska-Prymek H., Masny A., Salamatin R., Wesołowska M., Gołąb E. 2012. Human dirofilariosis in Poland: the first cases of autochthonous infections with Dirofilaria repens. Annals of Agricultural and Environmental Medicine: AAEM, 19, 445–450. PMid: 23020037.
• Èngel’štejn A.S., Kigel’ R.M., Zaporožec G.I. 1973. [Human invasion by Dirofilaria repens]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 42, 35 (In Russian). PMid: 4770433.
• Genchi C., Rinaldi L., Mortarino M., Genchi M., Cringoli G. 2009. Climate and Dirofilaria infection in Europe. Veterinary Parasitology, 163, 286–292. DOI: 10.1016/j.vetpar.2009.03.026.
• Genchi C., Kramer L.H., Rivasi F. 2011a. Dirofilarial infections in Europe. Vector-Borne and Zoonotic Diseases, 11, 1307–1317. DOI: 10.1089/vbz.2010.0247.
• Genchi C., Mortarino M., Rinaldi L., Cringoli G., Traldi G., Genchi M. 2011b. Changing climate and changing vector-borne disease distribution: the example of Dirofilaria in Europe. Veterinary Parasitology, 176, 295–299. DOI: 10.1016/j.vetpar.2011.01.012.
• Gerbilśkij V.L. 1951. [Experiences of an academic medical department in providing expert assistance to health care providers]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 20, 264–266 (In Russian).
• Gerbilśkij V.L, Dorogań D.A. 1961. [A case of dirofilariasis in man]. In: Problemy Parazitologii. Trudy Ukrainskogo Respublikanskogo Naučnogo Obŝestva Parazitologov, No. 1, Kyiv, 339–44 (In Russian).
• Gogina N.D. 1970. [Subcutaneous dirofilariasis of the lower eyelid]. Oftal’mologičeskij Žurnal, 25, 465–466 (In Russian). PMid: 5511008.
• Gudumac E., Plăcintă G., Vulpe V., Raducan M. 2011. Dirofilarioza subcutană — prezentare de caz clinic. Anale Ştiinţifice = Scientific Annals, 14, 17–19 (In Moldovan).
• Kuzmin Yu., Varodi E., Vasylyk N., Kononko G. 2005. Experimental infection of mosquitoes with Dirofilaria repens (Nematoda, Filarioidea) larvae. Vestnik Zoologii, 39, 19–24.
• Mănescu R., Bărăscu D., Mocanu C., Pîrvănescu H., Mîndriă I., Bălăşoiu M., Turculeanu A. 2009. Nodul subconjunctival cu Dirofilaria repens. Chirurgia. Uniunea Societătilor de Stiinte Medicale din Romania, 104, 95–97 (In Romanian). PMid: 19388575.
• Masny A., Gołąb E., Cielecka D., Sałsamatin R. 2013. Vector-borne helminths of dogs and humans — focus on central and eastern parts of Europe. Parasites and Vectors, 6, 38. DOI: 10.1186/1756-3305-6-38.
• Melńičenko A.P., Prosvetova T.A. 1971. [Second case of human dirofilariasis in the Poltava region]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 40, 238–239 (In Russian). PMid: 5568413.
• Mukvoz L.G., Belozerskaa N.I. 1975. [Two clinical cases of human dirofilariasis in the town of Zaporozhie]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 44, 615 (In Russian). PMid: 1219361.
• Naralenkova E.I. 2004. [Notification of cases of dirofilariasis in the Gomel region]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 2, 49–51. PMid: 15193055.
• Novak V.A., Drozdov A.A., Gribonosov S.N., Lapikova N.V. 2010. [Cases of parasitic invasion of the eyeball and adnexa in humans]. In: Materìali XII Z’izdu Oftal’mologìv Ukraïni, 26–28 travna 2010 r., Odesa, p. 302 (In Russian).
• Pampiglione S., Canestri Trotti G., Rivasi F. 1995. Human dirofilariasis due to Dirofilaria (Nochtiella) repens: a review of world literature. Parassitologia, 37, 149–193. PMid: 8778658.
• Pampiglione S., Rivasi F. 2000. Human dirofilariasis due to Dirofilaria (Nochtiella) repens: an update of world literature from 1995 to 2000. Parassitologia, 42, 231–254. PMid: 11686084.
• Pavlikovśka T., Nikolaênko S. 2011. [Current problems with vectorborne diseases]. Aktualńì problemi transmòsivnih parazitozìv. SES Profčlaktična Medicina, 4, 68–71 (In Ukrainian).
• Petropavlovskìj N.I. 1904. [Filaria immitis in the blood of dogs]. Arhiv “Veterinarnyh Nauk”, 34, 484–492 (In Russian).
• Popescu I., Tudose I., Racz P., Muntau B., Giurcaneanu C., Poppert S. 2012. Human Dirofilaria repens infection in Romania: a case report. Case Reports in Infectious Diseases, 2012, 472976. DOI: 10.1155/2012/472976.
• Poppert S., Hodapp M., Krueger A., Hegasy G., Niesen W.D., Kern W.V., Tannich E. 2009. Dirofilaria repens infection and concomitant meningoencephalitis. Emerging Infectious Diseases, 15, 1844–1846. DOI: 10.3201/eid1511.090936.
• Prosvetova T.A, Melńičenko A.P. 1971. [Cases of human dirofilariasis in the Poltava region]. In: (Ed. V.Â. Podolan) Materialy po medicinskoj geografii levoberežnoj Ukrainy (Doklady na konferencii v oktabre 1969 g., Poltava). Leningrad, Geografičeskoe Obsestvo SSSR, pp. 118–119 (In Russian).
• Rozenbaum R.S. 1970. [A case of human dirofilariasis]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 39, 620 (In Russian). PMid: 5511254.
• Sergiev V.P, Supraga V.G, Darčenkova N.N, Žukova L.A, Ivanova T.N. 2011. [Human dirofilariasis in Russia]. Rossijskij Parazitologičeskij Žurnal, 4, 60–64.
• Simón F., Siles-Lucas M., Morchón R., González-Miguel J., Mellado I., Carretón E., Montoya-Alonso J.A. 2012. Human and animal dirofilariasis: the emergence of a zoonotic mosaic. Clinical Microbiology Reviews, 2012, 25, 507–544. DOI: 10.1128/CMR.00012-12.
• Skrabin K.I., Al’tgauzen Â.Â., Šul’man E.S. 1930. [First case of Dirofilaria repens in man]. Tropičeskaâ-Medicina i Veterinariâ, 8, 9–11 (In Russian).
• Šupik A.L., Sokova L.A., Prosvetova T.A. 1967. [A case of human dirofilariasis]. Medicinskaa Parazitologiâ i Parazitarnye Bolezni, 36, 239 (In Russian). PMid: 5618843.
• Suprâga V.G, Cybina T.N, Denisova T.N, Morozov E.N, Romanenko N.A, Starkova T.V. 2004. [The first case of diagnosis of dirofilariasis from the microfilariae detected in the human subcutaneous tumor punctate]. Medicinskaâ Parazitologiâ i Parazitarnye Bolezni, 4, 6–8 (In Russian). PMid: 15689127.
• Sušarnik A.S, Peremykin G.L. 1975. [Dirofilariasis of the eyelid]. Oftal’mologičeskij Žurnal, 30, 54–55 (In Russian). PMid: 1118118.
• Szénási Z., Kovács A.H., Pampiglione S., Fioravanti M.L., Kucsera I., Tánczos B., Tiszlavicz L. 2008. Human dirofilariosis in Hungary: an emerging zoonosis in central Europe. Wiener Klinische Wochenschrift, 120, 96–102. DOI: 10.1007/s00508-008-0928-2.
• Žaboedov G.D., Šupik A.L. 1976. [Case of dirofilariasis of the eye in the Poltava region]. Oftal’mologičeskij Žurnal, 31, 467–468 (In Russian). PMid: 980362.