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2019 | 75 | 08 |
Tytuł artykułu

Udział wybranych genów w nowotworzeniu na poziomie molekularnym

Autorzy
Warianty tytułu
EN
Influence of selected genes on neogenesis at the molecular level
Języki publikacji
PL
Abstrakty
PL
The paper describes the influence of selected genes on neogenesis, including their expression, RNA transformation, translation and transcription. The role of adhesive molecules, extracellular matrix, cytoskeleton and signal conduction in neoplastic induction is described. External stimuli, internal factors and disturbances in DNA repair can cause cell mutations (fig. 1). An accumulation of various factors in different gene classes, together with their amplification, leads to tumour formation. Neoplastic cells undergo a dominant mutation, thereby gaining a new function, or cumulate recessive mutations which cause the loss of a function. This is particularly true in genetic anomalies associated with the cadherin system, e.g. the loss of E-cadherin expression in mammary cancer. The loss of E-cadherin or catenin expression causes the loss of cell connections, which facilitates metastasizing. Cells in metastases often show genetic disorders, a more malignant phenotype and increased drug resistance, which worsens clinical prognosis. The search for new anti-neoplastic drugs for humans is based on molecular studies and mice experimental models. The animals in these models show a phenotype corresponding with specific human diseases, e.g. Pax gene mutation in sarcomas and carcinomas, antisense DNA therapy (in Burkitt’s lymphoma or chronic leukaemia) or induction of retroviral vectors (thymidine kinase gene) in herpes virus (HS-th) in proliferating cells in multiform glioblastoma.
Wydawca
-
Rocznik
Tom
75
Numer
08
Opis fizyczny
s.451-458,rys.,bibliogr.
Twórcy
autor
  • Zakład Patomorfologii i Weterynarii Sądowej, Katedra Patologii, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy we Wrocławiu, ul.Norwida 31, 50-375 Wrocław
Bibliografia
  • Atkins P. W.: The periodic kingdom. Basic Books, New York 1995.
  • Bertram J. S.: The molecular biology of cancer. Mol. Aspects Med. 2001, 1, 167-173.
  • Brown T. A.: Genomes. Wiley-Liss, New York 1999.
  • Epstein R. J.: Biologia molekularna człowieka. Wyd. Czelej, Lublin 2005.
  • Gutkind J. S. (pod red.): Signalling networks and cell cycle control: the molecular basis of cancer and other diseases. Human Press. Champaing II, 2000.
  • Hanahan D., Weiberg R. A.: Hallmarks of cancer: the next generation. Cell 2011, 144, 646-674.
  • Kawiak J., Zabel M.: Seminaria z cytofizjologii. Wyd. 2, Elsevier Urban&Partner, Wrocław 2014.
  • Krauss G. (pod red.): Biochemistry of signal transduction and regulation. John Wiley&Sons, New York 2000.
  • Madej J. A.: Udział zapalenia starczego (ang. inflammaging) w procesie onkogenezy. Med. Weter. (w druku).
  • Madej J. A., Klimentowski S., Kuźmak J.: Role of p53 gene in pathogenesis of bovine leukemia (BLV-induced). Pol. Vet. Sci. 2001, 4, 225-230.
  • Meager A. (red.): Gene therapy technologies, applications and regulations: from laboratory to clinic. John Wiley&Sons, New York 1999.
  • Pearson J. D. (red.): Vascular adhesion molecules and inflammation. Springer – Verlag, Berlin 1999.
  • Pecorino L.: Molecular biology of cancer. Mechanisms, Targets and Therapeutic. Oxford University Press 2012.
  • Richter J. D. (red.): mRNA formation and function. Academic Press, New York 1997.
  • Seriver C. R., Beaudet A. L., Sly W. S. (red.): The metabolic and molecular bases of inherited disease. McGraw Hill, New York 2000.
  • Silbernagl S., Lange F.: Atlas patofizjologii. MedPharm Polska, Wrocław 2011.
  • Stein G. S. (red.): The molecular basis of cell cycle and growth control. Wiley, New York 1998.
  • Strachan T., Lindsay S., Wilson D. I. (red.): Molecular genetics of early human development. Academic Press, New York 2000.
  • Vogelstein B., Kinzler K. W.: Cancer genes and the pathways they control. Nat. Med. 2004, 10, 789-799.
  • www.cancer.org Website of the American Cancer Society; aimed at patients and relatives bot gives some basic data on cancer and its treatment.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-c16b146f-e3ee-41e1-8efc-671f34620c7f
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