Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice. A multiple case study

• Autorzy: Jakubowska M. , Sniegocka M. , Podgorska E. , Michalczyk-Wetula D. , Urbanska K. , Susz A. , Fiedor L. , Pyka J. , Plonka P. M.
• Języki publikacji: EN

Abstrakty

EN

 Lung adenocarcinoma is a leading human malignancy with fatal prognosis. Ninety percent of the deaths, however, are caused by metastases. The model of subcutaneous tumor xenograft in nude mice was adopted to study the growth of control and photodynamically treated tumors derived from the human A549 lung adenocarcinoma cell line. As a side-result of the primary studies, observations on the metastasis of these tumors to the murine lungs were collected, and reported in the present paper. The metastasizing primary tumors were drained by a prominent number of lymphatic vessels. The metastatic tissue revealed the morphology of well-differentiated or trans-differentiated adenocarcinoma. Further histological and histochemical analyses demonstrated the presence of golden-brown granules in the metastatic tissue, similar to these found in the tumor tissue. In contrast to the primary tumors, the electron paramagnetic resonance spectroscopy revealed no nitric oxide - hemoglobin complexes (a source of intense paramagnetic signals), in the metastases. No metastases were found in other murine organs; however, white infarctions were identified in a single liver. Taken together, the A549-derived tumors growing subcutaneously in nude mice can metastasize and grow on site in the pulmonary tissue. Thus, they can represent an alternative for the model of induced metastatic nodule formation, following intravenous administration of the cancerous cells.

Słowa kluczowe

EN

histological analysis; metastasis; lung adenocarcinoma; tumour; nude mice; mice; mouse; photodynamic therapy

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2013
• Tom: 60
• Numer: 3
• Opis fizyczny: p.323-330,fig.,ref.

Twórcy

autor

Jakubowska M.

• Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

autor

Sniegocka M.

• Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

autor

Podgorska E.

• Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

autor

Michalczyk-Wetula D.

• Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

autor

Urbanska K.

• Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

autor

Susz A.

• Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
• Faculty of Chemistry, Jagiellonian University, Krakow, Poland

autor

Fiedor L.

• Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

autor

Pyka J.

• Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

autor

Plonka P. M.

• Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

Bibliografia

• Adiseshaiah P, Lindner DJ, Kalvakolanu DV, Reddy SP (2007) FRA-1 Proto-oncogene induces lung epithelial cell invasion and anchorage-independent growth in vitro, but is insufficient to promote tumor growth in vivo. Cancer Res 67: 6204-6211. 
• Chamulitrat W, Jordan S, Mason R, Litton A, Wilson J, Wood E, Wolberg G, Molina y Vedia L (1995) Targets of nitric oxide in a mouse of liver inflammation by Corynebacterium parvum. Arch Biochem Biophys 316: 30-37. 
• Chen WR, Zhu WG, Dynlacht JR, Liu H, Nordquist RE (1999) Long-term tumor resistance induced by laser photo-immunotherapy. Int J Cancer 81: 808-812. 
• Chen JJ, Lin YC, Yao PL, Yuan A, Chen HY, Shun CT, Tsai MF, Chen CH, Yang PC (2005) Tumor-associated macrophages: the double-edged sword in cancer progression. J Clin Oncol 23: 953-964. 
• Chlopicki S, Bartuś JB, Gryglewski RJ (1999) Biphasic response to lipopolysaccharide from E. coli in the isolated ventilated blood-perfused rat lung. J Physiol Pharmacol 50: 551-565. 
• Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420: 860-867. 
• Detty MR, Gibson SL, Wagner SJ (2004) Current clinical and preclinical photosensitizers for use in photodynamic therapy. J Med Chem 47: 3897-3915. 
• Double KL, Dedov VN, Fedorow H, Kettle E, Halliday GM, Garner B, Brunk TU (2008) The comparative biology of neuromelanin and lipofuscin in the human brain. Cell Mol Life Sci 65: 1669-1682. 
• Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, Moan J, Peng Q (1998) Photodynamic therapy. J Natl Cancer Inst 90: 889-905. 
• Douillard S, Rozec B, Bigot E, Aillet L, Patrice T (2013) Secondary reactive oxygen species production after pdt during pulmonary tumor growth in sera of nude mice. Photodiagnosis Photodyn Ther 10: 62-71. 
• Elas M, Bielanska J, Pustelny K, Plonka P, Drelicharz L, Skorka T, Tyrankiewicz U, Wozniak M, Heinze-Paluchowska S, Walski M, Wojnar L, Fortin D, Ventura-Clapier R, Chlopicki S (2008) Detection of mitochondrial dysfunction by EPR technique in mouse model of dilated cardiomyopathy. Free Radic Biol Med 45: 321-328. 
• Emanuel NM, Saprin AN, Shabalkin VA, Kozlova LE, Krugljakova KE (1969) Detection and investigation of a new type of esr signal characteristic of some tumour tissues. Nature 222: 165-167. 
• Enochs WS, Nilges MJ, Swartz HM (1993) A standardized test for identification and characterization of melanins using electron paramagnetic resonance (EPR) spectroscopy. Pigment Cell Res 6: 91-99. 
• Feldman JP, Goldwasser R, Mark S, Schwartz J, Orion I (2009) A mathematical model for tumor volume evaluation using two-dimensions. J Appl Quant Methods 4: 455-462.
• Fidler IJ (1986) Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis. Cancer Metastasis Rev 5: 29-49. 
• Fidler IJ, Naito S, Pathak S (1990) Orthotopic implantation is essential for the selection, growth and metastasis of human real cell cancer in nude mice. Cancer Metastasis Rev 9: 149-165. 
• Fiedor L, Rosenbach-Belkin V, Scherz A (1992) The stereospecific interaction between chlorophylls and chlorophyllase. possible implication for chlorophyll biosynthesis and degradation. J Biol Chem 267: 22043-22047. 
• Fontana A (1912) Verfahren zur intensiver und raschen Farbung des Treponema pallidum und anderer Spirochäten. Dermatol Wochenschr 55: 1003-1004 (in German).
• Giard DJ, Aaronson SA, Todaro GJ, Arnstein P, Kersey JH, Dosik H, Parks WP (1973) In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst 51: 1417-1423. 
• Goto H, Yano S, Zhang H, Matsumori Y, Ogawa H, Blakey DC, Sone S (2002) Activity of a new vascular targeting agent, ZD6126, in pulmonary metastases by human lung adenocarcinoma in nude mice. Cancer Res 62: 3711-3715. 
• Gutschner T, Hämmerle M, Eißmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Groß M, Zörnig M, MacLeod AR, Spector DL, Diederichs S (2013) The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res 73: 1180-1189. 
• Haque A, Noman AS, Koide N, Odkhuu E, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T (2011) An ADP ribosylation factor-gtpase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide. Cancer Immunol Immunother 60: 1439-1446. 
• Jakubowska M, Szczygiel M, Michalczyk-Wetula D, Susz A, Stochel G, Elas M, Fiedor L, Urbanska K (2013a) Zinc-pheophorbide a-Highly efficient low-cost photosensitizer against human adenocarcinoma in cellular and animal models. Photodiagnosis Photodyn Ther 10: 266-277. 
• Jakubowska M, Michalczyk-Wetula D, Pyka J, Susz A, Urbanska K, Płonka BK, Kuleta P, Łącki P, Krzykawska-Serda M, Fiedor L, Płonka PM (2013b) Nitrosylhemoglobin in photodynamically stressed human tumors growing in nude mice. Nitric Oxide, in press, DOI: 10.1016/j.niox.2013.08.004. 
• Kozlowski JM, Fidler IJ, Campbell D, Xu ZI, Kaighn ME, Hart IR (1984) Metastatic behavior of human tumor cell lines grown in the nude mouse. Cancer Res 44: 3522-3529. 
• Krzykawska M, Dabrowski JM, Szczygiel M, Stochel G, Arnaut LG, Pereira MM, Urbanska K, Elas M (2012) Non-invasive prognostic tools for phototherapeutic response in murine tumors. Eur J Cancer 48 (Suppl 5): S193.
• Maruyama T, Kataoka N, Nagase S, Nakada H, Sato H, Sasaki H (1971) Identification of three-line electron spin resonance signal and its relationship to ascites tumors. Cancer Res 31: 179-184. 
• Masson P (1914) La grande endocrine de l'intestin chez l'homme. Les Comptes Rendus de l'Académie des sciences (Paris) 138: 59-61 (in French).
• Moghissi K (2008) Role of Photodynamic Therapy (PDT) in Lung Cancer. In Advances in Photodynamic Therapy. Basic, Translational, and Clinical, Hamblin MR, Mróz P, eds, pp 443-459. Artech House: Boston|London.
• Momma T, Hamblin MR, Wu HC, Hasan T (1998) Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis. Cancer Res 58: 5425-5431. 
• Nguyen DX, Bos PD, Massagué J (2009) Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-285. 
• Ohta Y, Shiraishi H, Tabata Y (1985) An electron spin resonance study of free radicals in black dust deposited in human lungs. Arch Environ Health 40: 279-282. 
• Oien KA, Stewart I, Jefrey Evans TR (2007) Unknown Primary. In The Cancer Handbook, Alison MR, ed, vol. 1, pp. 852-865. John Wiley & Sons Ltd.: The Atrium, Southern Gate, Chichester.
• Peng Q, Warloe T, Moan J, Godal A, Apricena F, Giercksky KE, Nesland JM (2001) Antitumor effect of 5-aminolevulinic acid-mediated photodynamic therapy can be enhanced by the use of a low dose of Photofrin in human. Cancer Res 61: 5824-5832. 
• Plonka PM, Chlopicki S, Plonka BK, Jawien J, Gryglewski RJ (1999) Endotoxaemia in rats: detection of nitrosyl-haemoglobin in blood and lung by EPR. Curr Top Biophys 23: 47-53.
• Plonka PM, Wisniewska M, Chlopicki S, Elas M, Rosen GM (2003) X-band and S-band EPR detection of nitric oxide in murine endotoxaemia using spin trapping by ferro-di(N-(dithio-carboxy)sarcosine). Acta Biochim Pol 50: 799-806. 
• Pogue BW, O'Hara JA, Demidenko E, Wilmot CM, Goodwin IA, Chen B, Swartz HM, Hasan T (2003) Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity. Cancer Res 63: 1025-1033. 
• Reed GH, Cohn M (1973) Electron paramagnetic resonance studies of manganese(II)-pyruvate kinase-substrate complexes. J Biol Chem 248: 6436-6442. 
• Schreck R (1936) Further quantitative methods for the study of transplantable tumors. The growth of R39 sarcoma and Brown-Pearce carcinomas. Am J Cancer 28: 345-363.
• Schreiber S, Gross S, Brandis A, Harmelin A, Rosenbach-Belkin V, Scherz A, Salomon Y (2002) Local photodynamic therapy (PDT) of rat C6 glioma xenografts with Pd-bacteriopheophorbide leads to decreased metastases and increase of animal cure compared with surgery. Int J Cancer 99: 279-285. 
• Slominski A, Paus R, Plonka P, Chakraborty A, Maurer M, Pruski D, Lukiewicz S (1994) Melanogenesis during the anagen-catagen-telogen transformation of the murine hair cycle. J Invest Dermatol 102: 862-869. 
• Slominski A, Paus R, Mihm MC (1998) Inhibition of melanogenesis as an adjuvant strategy in the treatment of melanotic melanomas: selective review and hypothesis. Anticancer Res 18: 3709-3716. 
• Szczygieł M, Urbanska K, Jurecka P, Stawoska I, Stochel G, Fiedor L (2008) Central metal determines pharmacokinetics of chlorophyll-derived xenobiotics. J Med Chem 51: 4412-4418. 
• van Deursen CT, van Dieijen-Visser MP, Koudstaal J, Brombacher PJ (1989) Determination of tissue iron and ferritin in liver pathology comparison of histochemical and biochemical results. J Clin Chem Clin Biochem 27: 345-349. 
• Wei Q, Jiang H, Xiao Z, Baker A, Young MR, Veenstra TD, Colburn NH (2011) Sulfiredoxin-peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling. Proc Natl Acad Sci USA 108: 7004-7009. 
• Yonetani T, Drott HR, Leigh JS, Reed GH, Waterman MR, Asakura T (1970) Electromagnetic properties of hemoproteins. III Electron paramagnetic resonance characteristics of iron(III) and manganese(II) protoporphyrins IX and their apohemoprotein complexes in high spin states. J Biol Chem 245: 2998-3003. 
• Zawistowski S (1983) Histological Technique, Histology and the Principles of Histopathology. PZWL, Warsaw (in Polish).