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2017 | 66 | 2 |

Tytuł artykułu

Early KPC-producing Klebsiella pneumoniae bacteremia among intensive care unit patients non-colonized upon admission

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Among 140 patients colonized by KPC-producing Klebsiella pneumoniae (KPC-Kp) between fourth and seventh day of Intensive Care Unit stay, 24 developed bacteraemia immediately after colonization. Colistin-resistance of the colonizing isolate was the factor significantly associated with early KPC-Kp bacteraemia (P <0.001; OR 6.6, 95% CI 2.4–18.4), a worrisome finding since infections by colistin-resistant isolates is associated with increased mortality due to limited remaining therapeutic options.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

66

Numer

2

Opis fizyczny

p.251-254,ref.

Twórcy

  • Division of Infectious Diseases, School of Medicine, University of Patras, Rion-Patras, Greece
autor
  • Division of Anaesthesiology and Intensive Care Medicine, School of Medicine, University of Patras, Rion-Patras, Greece
  • Department of Microbiology, School of Medicine, University of Patras, Rion-Patras, Greece
  • Department of Microbiology, School of Medicine, University of Patras, Rion-Patras, Greece
autor
  • Intensive Care Unit, Saint Andrew’s General Hospital of Patras, Patras, Greece
  • Department of Microbiology, School of Medicine, University of Patras, Rion-Patras, Greece
  • Division of Anaesthesiology and Intensive Care Medicine, School of Medicine, University of Patras, Rion-Patras, Greece
autor
  • Division of Anaesthesiology and Intensive Care Medicine, School of Medicine, University of Patras, Rion-Patras, Greece
  • Department of Microbiology, School of Medicine, University of Patras, Rion-Patras, Greece
  • Department of Microbiology, School of Medicine, University of Patras, Rion-Patras, Greece
autor
  • Division of Infectious Diseases, School of Medicine, University of Patras, Rion-Patras, Greece

Bibliografia

  • Borer A., L. Saidel-Odes, S. Eskira, R. Nativ, K. Riesenberg,I. Livshiz-Riven, F. Schlaeffer, M. Sherf and N. Peled. 2012. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K. pneumoniae. Am. J. Infect. Control.40: 421–425.
  • Chiang T.T., Y.S. Yang, K.M. Yeh, S.K. Chiu, N.C. Wang, T.Y. Lin, L.Y. Huang, F.Y. Chang, L.K. Siu, J.C. Lin and others. 2015. Quan-tification and comparison of virulence and characteristics of dif-ferent variants of carbapenemase-producing Klebsiella pneumoniaeclinical isolates from Taiwan and the United States. J. Microbiol. Immunol. Infect. 49: 83–90.
  • Diago-Navarro E., L. Chen, V. Passet, S. Burack, A. Ulacia-Her-nando, R.P. Kodiyanplakkal, M.H. Levi, S. Brisse, B.N. Kreiswirthand B.C. Fries. 2014. Carbapenem-resistant Klebsiella pneumoniaeexhibit variability in capsular polysaccharide and capsule associated virulence traits. J. Infect. Dis. 210: 803–813.
  • European Committee on Antimicrobial Susceptibility Testing (EUCAST). 2015. Breakpoint tables for interpretation of MICs and zone diameters. Version 5.0. http://www.eucast.org, 2016.06.23.
  • Falcone M., A. Russo, A. Iacovelli, G. Restuccia, G. Ceccarelli, A. Giordano, A. Farcomeni, A. Morelli and M. Venditti. 2016. Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Clin. Microbiol. Infect. 22: 444–450.
  • Giacobbe D.R., V. Del Bono, E.M. Trecarichi, F.G. De Rosa,M. Giannella, M. Bassetti, A. Bartoloni, A.R. Losito, S. Corcione, M. Bartoletti and others. 2015. Risk factors for bloodstream infec-tions due to colistin-resistant KPC-producing Klebsiella pneu-moniae: results from a multicenter case-control-control study. Clin. Microbiol. Infect. 21(1106): e1–8.
  • Giannella M., E.M. Trecarichi, F.G. De Rosa, V. Del Bono,M. Bassetti, R.E. Lewis, A.R. Losito, S. Corcione, C. Saffioti,M. Bartoletti and others. 2014. Risk factors for carbapenem-resis-tant Klebsiella pneumoniae bloodstream infection among rectal car-riers: a prospective observational multicentre study. Clin. Microbiol. Infect. 20: 1357–1362.
  • Queenan A.M. and K. Bush. 2007. Carbapenemases: the versatile beta-lactamases (table of contents). Clin. Microbiol. Rev. 20: 440–458.
  • Schechner V., T. Kotlovsky, M. Kazma, H. Mishali, D. Schwartz, S. Navon-Venezia, M.J. Schwaber and Y. Carmeli. 2013. Asymp-tomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected? Clin. Microbiol. Infect. 19: 451–456.
  • Tischendorf J., R.A. de Avila and N. Safdar. 2016. Risk of infection following colonization with carbapenem-resistant Enterobactericeae:A systematic review. Am. J. Infect. Control. 44: 539–543

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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