PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2012 | 72 | 1 |

Tytuł artykułu

Long-lasting stress, quantitative changes in nitric oxide concentration and functional state of brain mitochondria

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
We have studied biochemical changes occurring in brain cell mitochondria of white rats on the background of stress induced by 30-day isolation and disruption of circadian rhythms. It was ascertained that due to long-lasting stress, there occurs activation of oxidative processes in mitochondria as well as inhibition of anti-oxidant system activity, causing development of energy deficiency in brain cells. The above-mentioned biochemical processes become the reason for activation and opening of the mitochondrial permeability transition pore (MPTP), which, in its turn, signals the start of neuroapoptosis and various neurodegenerative processes.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

72

Numer

1

Opis fizyczny

p.40-50,fig.,ref.

Twórcy

  • Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia
autor
  • Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia
autor
  • Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia
autor
  • Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia
  • Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia
autor
  • The G. Zaldastanishvili American Academy in Tibilisi, Georgia
  • Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia

Bibliografia

  • Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS (2002) Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA recep¬tor activation. J Neurochem 80: 531-538.
  • Albensi BC, Sullivan PG, Thompson MB, Scheff SW, Mattson MP (2000) Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity. Exp Neurol 162: 385-389.
  • Ando T, Mimura K, Johansson CCh, Hanson M, Mougiakakos D, Larsson Ch, Martins da Palma T (2008) Transduction with the antioxidant enzyme catalase protects human t cells against oxidative stress. J Immun 18: 8382-8390.
  • Atlante A (1997) Glutamate neurotoxicity in rat cerebellar granule cells: a major role for xanthine oxidase in oxygen radical formation. J Neurochem 68: 2038-2045.
  • Bottino R, Balamurugan AN, Tse H, Thirunavukkarasu C (2004) Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes 53: 2559-2567.
  • Bounous G, Molson JH (2003) Antioxidant system. Anticancer Res 23: 1411-1416.
  • Brorson JR, Schumacker PT, Zhang H (1999) Nitric oxide acutely inhibits neuronal energy production. J Neurosci 19: 147-158.
  • Cao W, Carney JM, Duchon A, Floyd RA, Chevion M (1988) Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci Lett 88: 233-238.
  • Cenci S, Sitia R (2007) Managing and exploiting stress in the antibody factory. FEBS Lett 581: 3652-3657.
  • Comim CM, Cassol-Jr OJ, Constantino LS, Felisberto F, Petronilho F (2011) Alterations in inflammatory media¬tors, oxidative stress parameters and energetic metabo¬lism in the brain of sepsis survivor rats. Neurochem Res 36: 304-311.
  • Da-Silva WS, Gomez-Puyou A, de Gomez-Puyou MT, Moreno-Sanchez R, De Felice FG, de Meis L (2004) Mitochondrial bound hexokinase activity as a preventive antioxidant defense. J Biol Chem 279: 39846-39855.
  • Doczi J, Turiak L, Vajda S, Mandi M, Tôrôcsik B (2011) Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with rela¬tion to the bioenergetic state. J Biol Chem 286: 6345¬6353.
  • Dolder M, Walzel B, Speer O, Schlattner U, Wallimann T (2003) Inhibition of the mitochondrial permeability tran¬sition by creatine kinase substrates. Requirement for microcompartmentation. J Biol Chem 278: 17760¬17766.
  • Dubinina EE, Gavrovskaya SV, Kuzmich EV, Leonova NV, Morozova MG (2002) Oxidative modification of pro¬teins: oxidation of tryptophan and production of dity- rosine in purified proteins using Fenton's system. Biochemistry (Mosc) 67: 343-350.
  • Fiskum G (2000) Mitochondrial participation in ischemic and traumatic neural cell death. J Neurotrauma 17: 843¬855.
  • Friedlander RM (2003) Apoptosis and caspases in neurode¬generative diseases. N Engl J Med 348: 1365-1375.
  • Giordano FJ (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115: 500-508.
  • Gopalakrishna R, Jaken S (2000) Protein kinase C signaling and oxidative stress. Free Radic Biol Med 28: 1349¬1361.
  • Ilieva EV, Ayala V, Jove M (2007) Oxidative and endoplas- mic reticulum stress interplay in sporadic amyotrophic lateral sclerosis. Brain 130: 3111-3123.
  • Kern JC, Kehrer JP (2005) Free radicals and apoptosis: rela¬tionships with glutathione, thioredoxin and the BCL fam¬ily of proteins. Front Biosci 10: 1727-1738.
  • Kilbride SM, Telford JE, Tipton KF, Davey GP (2008) Partial inhibition of complex I activity increases Ca-independent glutamate release rates from depolarized synaptosomes. J Neurochem 106: 826-834.
  • Kroemer G, Galluzzi L, Brenner C (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87: 99-163.
  • Lacza Z, Pankotai E, Csordas A, Gero D, Kiss L, Horvath EM, Kollai M, Busija DW, Szabo C (2006) Mitochondrial NO and reactive nitrogen species production: Does mtNOS exist? Nitric Oxide 162-168.
  • Lin KT, Xue JY, Sun FF (1997) Reactive oxygen species participate in peroxynitrite-induced apoptosis in HL-60 cells. Biochem Biophys Res Commun 230: 115-121.
  • Maekawa T, Kim S, Nakai D, Makino Ch, Takagi T, Ogura H, Yamada K (2010) Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. The EMBO J 29: 196 - 208.
  • Masood A, Banerjee B, Vijayan VK, Ray A (2006) Modulation of stress-induced neurobehavioral changes by nitric oxide in rats. Eur J Pharmacol 458: 135-143.
  • Mateo J, Garcia-Lecea M, Cadenas S, Hernandez C, Moncada S (2003) Regulation of hypoxia-inducible factor-1a by nitric oxide through mitochondria-dependent and -inde¬pendent pathways. Biochem J 376: 537-544.
  • McCord JM, Edeas M (2005) SOD, oxidative stress and human pathologies: a brief history and a future vision. Biomed and Pharm 59: 139-144.
  • Michara M, Uchiyama M (1978) Determination of malonal- dehyde precursor in tissues by thiobarbituric acid test. Biochem J 86: 271-278.
  • Miyadera H, Shiomi K, Ui H, Yamaguchi Y, Masuma R, Tomoda H, Miyoshi H (2003) Atpenins, potent and spe¬cific inhibitors of mitochondrial complex II (succinateu- biquinone oxidoreductase). Proc Natl Acad Sci USA 100: 473-477.
  • Navarro A (2008) Boveris Mitochondrial nitric oxide syn- thase, mitochondrial brain dysfunction in aging, and mitochondria-targeted antioxidants. Adv Drug Delivery Rev 60: 1534-1544.
  • Pahan K, Liu X, McKinney MJ, Wood C, Sheikh FG (2000) Raymond JR Induction of nitrid oxide synthaze and acti¬vation of nuclear factor-kB in primary astrocytes. J Neurochem 74: 2288-2295.
  • Paolocci N, Jackson MI, Lopez BE, Tocchetti CG, Wink DA, Hobbs AJ, Fukuto JM (2007) The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO. Pharmacol Ther 113: 442-458.
  • Pastorino JG, Hoek JB (2003) Hexokinase II: The integra¬tion of energy metabolism and control of apoptosis. Curr Med Chem 10: 1535-1551.
  • Perez Nievas BG, Hammerschmidt T, Kummer MP, Terwel D (2011) Restraint stress increases neuroinflammation independently of amyloid P levels in amyloid precursor protein/PS1 transgenic mice. J Neurochem 11: 43-52.
  • Pshennikova MG, Popkova EV, Bondarenko NA, Malyshev IIu, Shimkovich MV (2002) Catecholamines, nitrogen oxide, and resistivity to stressor lesions: effect of adapta¬tion to hypoxia. Ross Fiziol Zh Im IM Sechenova 88: 485-495.
  • Reddy PH, Beal MF(2008) Amyloid P, mitochondrial dys¬function and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 14: 45-53.
  • Schapira AH, Jenner P (2011) Etiology and pathogenesis of Parkinson's disease. Mov Disord 26: 1049-1055.
  • Schmidt C, Lepsverdize E, Chi SL, Das AM, Pizzo SV, Dityatev A, Schachner M (2008) Amyloid precursor pro¬tein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. Mol Psychiatry 13: 953-969.
  • Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K (2007) Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55: 412-424.
  • Sinner C, Kaehler ST, Philippu A, Singewald N (2001) Role of nitric oxide in the stress-induced release of serotonin in the locus coeruleus. Naunyn Schmiedebergs Arch Pharmacol 364: 105-109.
  • Skornyakov VI, Kozhemyakin LA, Smirnov VV, Poliakova MA, Chulkevich GF (1988) Products in lipid peroxida- tion cerebrospinal fluid in patients with craniocerebral traumas (in Russian). Lab Delo 8: 14-16.
  • Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H (2005) Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant a-synucleininduced toxicity. Hum Mol Genet 14: 3801-3811.
  • Sullivan PG, Thompson M, Scheff SW (2000) Continuous infusion of cyclosporin A postinjury significantly amelio¬rates cortical damage following traumatic brain injury. Exp Neurol 161: 631-637.
  • Szabó C, Zingarelli B, O'Connor M, Salzman AL (1996) DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci U S A 5: 1753-1758.
  • Takeuchi K, Toyohara H, Sakaguchi M (2000) A hyperos¬motic stress-induced mRNA of carp cell encodes Na (+)- and Cl(-)-dependent high affinity taurine transporte. Biochim Biophys Acta 1464: 219-230.
  • Tasset I, Peña J, Jimena I, Feijóo M, Del Carmen Muñoz M, Montilla P, Túnez I (2008) Effect of 17beta-estradiol on olfactory bulbectomy-induced oxidative stress and behav¬ioral changes in rats. Neuropsychiatr Dis Treat 4: 441¬449.
  • Thomas DD, Miranda KM, Colton CA, Citrin D, Espey MG, Wink DA (2003) Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. Antioxid Redox Signal 5: 307-317.
  • Ueda I, Wada T (1970) Determination of inorganic phos¬phate by the molybdovanadate method in the presence of ATP and some interfering organic bases. Anal Biochem 37: 169-174.
  • Whittaker VP (1969) The synaptosome, In: Handbook of Neurochemistry Vol. 2 (Lajtha A, Ed.) Plenum Press, New York, NY, p. 327-363.
  • Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism. Physiol Rev 80: 1107-1121.
  • Zamzami N, Kroemer G (2001) The mitochondrion in apop- tosis: how Pandora's box opens. Nat Rev Mol Cell Biol 2: 67-71.
  • Zhuravliova E, Barbakadze T, Zaalishvili E, Chipashvilic M, Koshoridze N, Mikeladze D (2009) Social isola¬tion in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase. Behav Brain Res 205: 377-383.

Uwagi

Rekord w opracowaniu

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-c020f74f-0b34-4674-8e2b-4819651bf4ae
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.