Long-lasting stress, quantitative changes in nitric oxide concentration and functional state of brain mitochondria

• Autorzy: Kuchukashvili Z. , Burjandze G. , Menabde K. , Chachua M. , Dachanidze N. , Mikadze M. , Koshoridze N.
• Języki publikacji: EN

Abstrakty

EN

We have studied biochemical changes occurring in brain cell mitochondria of white rats on the background of stress induced by 30-day isolation and disruption of circadian rhythms. It was ascertained that due to long-lasting stress, there occurs activation of oxidative processes in mitochondria as well as inhibition of anti-oxidant system activity, causing development of energy deficiency in brain cells. The above-mentioned biochemical processes become the reason for activation and opening of the mitochondrial permeability transition pore (MPTP), which, in its turn, signals the start of neuroapoptosis and various neurodegenerative processes.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2012
• Tom: 72
• Numer: 1
• Opis fizyczny: p.40-50,fig.,ref.

Twórcy

autor

Kuchukashvili Z.

• Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia

autor

Burjandze G.

• Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia

autor

Menabde K.

• Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia

autor

Chachua M.

• Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia

autor

Dachanidze N.

• Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia

autor

Mikadze M.

• The G. Zaldastanishvili American Academy in Tibilisi, Georgia

autor

Koshoridze N.

• Department of Biology, Faculty of Exact and Natural Sciences, I.Javakhishvili Tbilisi State University, Tibilisi, Georgia

Bibliografia

• Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS (2002) Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA recep¬tor activation. J Neurochem 80: 531-538.
• Albensi BC, Sullivan PG, Thompson MB, Scheff SW, Mattson MP (2000) Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity. Exp Neurol 162: 385-389.
• Ando T, Mimura K, Johansson CCh, Hanson M, Mougiakakos D, Larsson Ch, Martins da Palma T (2008) Transduction with the antioxidant enzyme catalase protects human t cells against oxidative stress. J Immun 18: 8382-8390.
• Atlante A (1997) Glutamate neurotoxicity in rat cerebellar granule cells: a major role for xanthine oxidase in oxygen radical formation. J Neurochem 68: 2038-2045.
• Bottino R, Balamurugan AN, Tse H, Thirunavukkarasu C (2004) Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes 53: 2559-2567.
• Bounous G, Molson JH (2003) Antioxidant system. Anticancer Res 23: 1411-1416.
• Brorson JR, Schumacker PT, Zhang H (1999) Nitric oxide acutely inhibits neuronal energy production. J Neurosci 19: 147-158.
• Cao W, Carney JM, Duchon A, Floyd RA, Chevion M (1988) Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci Lett 88: 233-238.
• Cenci S, Sitia R (2007) Managing and exploiting stress in the antibody factory. FEBS Lett 581: 3652-3657.
• Comim CM, Cassol-Jr OJ, Constantino LS, Felisberto F, Petronilho F (2011) Alterations in inflammatory media¬tors, oxidative stress parameters and energetic metabo¬lism in the brain of sepsis survivor rats. Neurochem Res 36: 304-311.
• Da-Silva WS, Gomez-Puyou A, de Gomez-Puyou MT, Moreno-Sanchez R, De Felice FG, de Meis L (2004) Mitochondrial bound hexokinase activity as a preventive antioxidant defense. J Biol Chem 279: 39846-39855.
• Doczi J, Turiak L, Vajda S, Mandi M, Tôrôcsik B (2011) Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with rela¬tion to the bioenergetic state. J Biol Chem 286: 6345¬6353.
• Dolder M, Walzel B, Speer O, Schlattner U, Wallimann T (2003) Inhibition of the mitochondrial permeability tran¬sition by creatine kinase substrates. Requirement for microcompartmentation. J Biol Chem 278: 17760¬17766.
• Dubinina EE, Gavrovskaya SV, Kuzmich EV, Leonova NV, Morozova MG (2002) Oxidative modification of pro¬teins: oxidation of tryptophan and production of dity- rosine in purified proteins using Fenton's system. Biochemistry (Mosc) 67: 343-350.
• Fiskum G (2000) Mitochondrial participation in ischemic and traumatic neural cell death. J Neurotrauma 17: 843¬855.
• Friedlander RM (2003) Apoptosis and caspases in neurode¬generative diseases. N Engl J Med 348: 1365-1375.
• Giordano FJ (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115: 500-508.
• Gopalakrishna R, Jaken S (2000) Protein kinase C signaling and oxidative stress. Free Radic Biol Med 28: 1349¬1361.
• Ilieva EV, Ayala V, Jove M (2007) Oxidative and endoplas- mic reticulum stress interplay in sporadic amyotrophic lateral sclerosis. Brain 130: 3111-3123.
• Kern JC, Kehrer JP (2005) Free radicals and apoptosis: rela¬tionships with glutathione, thioredoxin and the BCL fam¬ily of proteins. Front Biosci 10: 1727-1738.
• Kilbride SM, Telford JE, Tipton KF, Davey GP (2008) Partial inhibition of complex I activity increases Ca-independent glutamate release rates from depolarized synaptosomes. J Neurochem 106: 826-834.
• Kroemer G, Galluzzi L, Brenner C (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87: 99-163.
• Lacza Z, Pankotai E, Csordas A, Gero D, Kiss L, Horvath EM, Kollai M, Busija DW, Szabo C (2006) Mitochondrial NO and reactive nitrogen species production: Does mtNOS exist? Nitric Oxide 162-168.
• Lin KT, Xue JY, Sun FF (1997) Reactive oxygen species participate in peroxynitrite-induced apoptosis in HL-60 cells. Biochem Biophys Res Commun 230: 115-121.
• Maekawa T, Kim S, Nakai D, Makino Ch, Takagi T, Ogura H, Yamada K (2010) Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. The EMBO J 29: 196 - 208.
• Masood A, Banerjee B, Vijayan VK, Ray A (2006) Modulation of stress-induced neurobehavioral changes by nitric oxide in rats. Eur J Pharmacol 458: 135-143.
• Mateo J, Garcia-Lecea M, Cadenas S, Hernandez C, Moncada S (2003) Regulation of hypoxia-inducible factor-1a by nitric oxide through mitochondria-dependent and -inde¬pendent pathways. Biochem J 376: 537-544.
• McCord JM, Edeas M (2005) SOD, oxidative stress and human pathologies: a brief history and a future vision. Biomed and Pharm 59: 139-144.
• Michara M, Uchiyama M (1978) Determination of malonal- dehyde precursor in tissues by thiobarbituric acid test. Biochem J 86: 271-278.
• Miyadera H, Shiomi K, Ui H, Yamaguchi Y, Masuma R, Tomoda H, Miyoshi H (2003) Atpenins, potent and spe¬cific inhibitors of mitochondrial complex II (succinateu- biquinone oxidoreductase). Proc Natl Acad Sci USA 100: 473-477.
• Navarro A (2008) Boveris Mitochondrial nitric oxide syn- thase, mitochondrial brain dysfunction in aging, and mitochondria-targeted antioxidants. Adv Drug Delivery Rev 60: 1534-1544.
• Pahan K, Liu X, McKinney MJ, Wood C, Sheikh FG (2000) Raymond JR Induction of nitrid oxide synthaze and acti¬vation of nuclear factor-kB in primary astrocytes. J Neurochem 74: 2288-2295.
• Paolocci N, Jackson MI, Lopez BE, Tocchetti CG, Wink DA, Hobbs AJ, Fukuto JM (2007) The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO. Pharmacol Ther 113: 442-458.
• Pastorino JG, Hoek JB (2003) Hexokinase II: The integra¬tion of energy metabolism and control of apoptosis. Curr Med Chem 10: 1535-1551.
• Perez Nievas BG, Hammerschmidt T, Kummer MP, Terwel D (2011) Restraint stress increases neuroinflammation independently of amyloid P levels in amyloid precursor protein/PS1 transgenic mice. J Neurochem 11: 43-52.
• Pshennikova MG, Popkova EV, Bondarenko NA, Malyshev IIu, Shimkovich MV (2002) Catecholamines, nitrogen oxide, and resistivity to stressor lesions: effect of adapta¬tion to hypoxia. Ross Fiziol Zh Im IM Sechenova 88: 485-495.
• Reddy PH, Beal MF(2008) Amyloid P, mitochondrial dys¬function and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 14: 45-53.
• Schapira AH, Jenner P (2011) Etiology and pathogenesis of Parkinson's disease. Mov Disord 26: 1049-1055.
• Schmidt C, Lepsverdize E, Chi SL, Das AM, Pizzo SV, Dityatev A, Schachner M (2008) Amyloid precursor pro¬tein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. Mol Psychiatry 13: 953-969.
• Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K (2007) Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55: 412-424.
• Sinner C, Kaehler ST, Philippu A, Singewald N (2001) Role of nitric oxide in the stress-induced release of serotonin in the locus coeruleus. Naunyn Schmiedebergs Arch Pharmacol 364: 105-109.
• Skornyakov VI, Kozhemyakin LA, Smirnov VV, Poliakova MA, Chulkevich GF (1988) Products in lipid peroxida- tion cerebrospinal fluid in patients with craniocerebral traumas (in Russian). Lab Delo 8: 14-16.
• Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H (2005) Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant a-synucleininduced toxicity. Hum Mol Genet 14: 3801-3811.
• Sullivan PG, Thompson M, Scheff SW (2000) Continuous infusion of cyclosporin A postinjury significantly amelio¬rates cortical damage following traumatic brain injury. Exp Neurol 161: 631-637.
• Szabó C, Zingarelli B, O'Connor M, Salzman AL (1996) DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci U S A 5: 1753-1758.
• Takeuchi K, Toyohara H, Sakaguchi M (2000) A hyperos¬motic stress-induced mRNA of carp cell encodes Na (+)- and Cl(-)-dependent high affinity taurine transporte. Biochim Biophys Acta 1464: 219-230.
• Tasset I, Peña J, Jimena I, Feijóo M, Del Carmen Muñoz M, Montilla P, Túnez I (2008) Effect of 17beta-estradiol on olfactory bulbectomy-induced oxidative stress and behav¬ioral changes in rats. Neuropsychiatr Dis Treat 4: 441¬449.
• Thomas DD, Miranda KM, Colton CA, Citrin D, Espey MG, Wink DA (2003) Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. Antioxid Redox Signal 5: 307-317.
• Ueda I, Wada T (1970) Determination of inorganic phos¬phate by the molybdovanadate method in the presence of ATP and some interfering organic bases. Anal Biochem 37: 169-174.
• Whittaker VP (1969) The synaptosome, In: Handbook of Neurochemistry Vol. 2 (Lajtha A, Ed.) Plenum Press, New York, NY, p. 327-363.
• Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism. Physiol Rev 80: 1107-1121.
• Zamzami N, Kroemer G (2001) The mitochondrion in apop- tosis: how Pandora's box opens. Nat Rev Mol Cell Biol 2: 67-71.
• Zhuravliova E, Barbakadze T, Zaalishvili E, Chipashvilic M, Koshoridze N, Mikeladze D (2009) Social isola¬tion in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase. Behav Brain Res 205: 377-383.

Uwagi

Rekord w opracowaniu