Genetic diversity of the long terminal repeat of bovine leukaemia virus field isolates

• Autorzy: Pluta A. , Rola-Luszczak M. , Olech M. , Kuzmak J.
• Języki publikacji: EN

Abstrakty

EN

In this study the sequences of the long terminal repeat (LTR) of field isolates of the bovine leukaemia virus (BLV) were analysed. These isolates came from emerging cases of BLV infection in cattle from herds having BLV-free status. We found several sequence variations within regulatory motifs in the LTRs like GRE, DAS and interferon binding site. These mutations can possibly affect transcriptional activity of the virus, leading to its silencing.

Słowa kluczowe

EN

genetic diversity; long terminal repeat; enzootic bovine leukemia; bovine leukemia virus; infection

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2015
• Tom: 59
• Numer: 4
• Opis fizyczny: p.447-450,fig.,ref.

Twórcy

autor

Pluta A.

• Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Rola-Luszczak M.

• Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Olech M.

• Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Kuzmak J.

• Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland

Bibliografia

• 1. Adam E., Kerkhofs P., Mammerickx M., Kettmann R., Burny A, Droogmans L., Willems L.: Involvement of the cyclic AMP- responsive element binding protein in bovine leukemia virus expression in vivo. J Virol 1994, 68, 5845-5853.
• 2. Angelopoulou K., Brellou G.D., Greenland T., Vlemmas I.: A novel deletion in the LTR region of a Greek small ruminant lentivirus may be associated with low pathogenicity. Virus Res 2006, 118, 178-184.
• 3. Calomme C., Nguyen T.L., de Launoit Y., Kiermer V., Droogmans L., Burny A., Van Lint C.: Upstream stimulatory factors binding to an E box motif in the R region of the bovine leukemia virus long terminal repeat stimulates viral gene expression. J Biol Chem 2002, 277, 8775-8789.
• 4. Dekoninck A., Calomme C., Nizet S., de Launoit Y., Burny A., Ghysdael J., Van Lint C.: Identification and characterization of a PU.l/Spi-B binding site in the bovine leukemia virus long terminal repeat. Oncogene 2003, 22, 2882-2896.
• 5. Derse D., Casey J.W.: Two elements in the bovine leukemia virus long terminal repeat that regulate gene expression. Science 1986, 231, 1437-1440.
• 6. Dube S., Abbott L., Dube D.K., Dolcini G., Gutierrez S., Ceriani C., Juliarena M., Ferrer J., Perzova R., Poiesz B.J.: The complete genomic sequence of an in vivo low replicating BLV strain. Virol J 2009, 6, 120, doi: 10.1186/1743-422X-6-120.
• 7. Dube S., Dolcini G., Abbott L., Mehta S., Dube D.. Gutierrez S., Ceriani C., Esteban E., Ferrer J., Poiesz B.: The complete genomic sequence of a BLV strain from a Holstein cow from Argentina J Virol 2000, 277, 379-386.
• 8. EFSA AHAW Panel (EFSA Panel on Animal Health and Welfare). Scientific opinion on enzootic bovine leukosis. EFSA J 2015, 13, 1-63. doi:10.2903/j.efsa.2015.4188.
• 9. Gillet N., Florins A., Boxus M., Burteau C., Nigro A., Vandermeers F., Balon H., Bouzar A.B., Defoiche J., Burny A., Reichert M., Kettmann R., Willems L.: Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human. Retrovirology 2007, 4, 18.
• 10. Kiermer V., Van Lint C., Briclet D., Vanhulle C., Kettmann R., Verdin E., Burny A., Droogmans L.: An interferon regulatory factor binding site in the U5 region of the bovine leukemia virus long terminal repeat stimulates Tax-independent gene expression. J Virol 1998, 72, 5526-5534.
• 11. Kiss-Toth E., Unk I.: A downstream regulatory element activates the bovine leukemia virus promoter. Biochem Biophys Res Commun 1994, 202, 1553-1561.
• 12. Kettmann R., Burny A., Callebaut I., Droogmans L., Mammerickx M., Willems L., Portetelle D.: Bovine leukemia virus. In: The Retroviridae, Plenum Press, New York, 1994, pp. 39-81.
• 13. Lorenz R., Straub O.C.: The problem of recurrence of enzootic bovine leucosis in previously cured herds. Dtsch Tierarztl Wochenschr 1994, 101, 158-162.
• 14. Niermann G.L., Buehring G.C.: Hormone regulation of bovine leukemia virus via the long terminal repeat. Virology 1997, 239, 249-258.
• 15. Neto W.K., Da-Costa A.C., de Oliveira A.C., Martinez V.P., Nukui Y., Sabino E.C., Sanabani S.S.: Correlation between LTR point mutations and proviral load levels among human T cell lymphotropic virus type 1 (HTLV-1) asymptomatic carriers. Virol J 2011, 8, 535. doi: 10.1186/1743-422X-8-535.
• 16. Murphy B., Hillman C., Castillo D., Vapniarsky N., Rowe J.: The presence or absence of the gamma-activated site determines IFN gamma-mediated transcriptional activation in CAEV promoters cloned from the mammary gland and joint synovium of a single CAEV-infected goat. Virus Res 2012, 163, 537-545. doi: 10.1016/j viruses.2011.12.001.
• 17. Zhao X., Jimenez C., Sentsui H., Buehring G.C.: Sequence polymorphisms in the long terminal repeat of bovine leukemia virus: evidence for selection pressures in regulatory sequences. Virus Res 2007, 124, 113-124.
• 18. Zhao X., McGirr K.M., Buehring G.C.: Evolutionary influences on overlapping reading frames in the bovine leukemia virus pXBL region. Genomics 2007, 89, 502-511. doi: 10.1016/j.ygeno.2006.12.00.

Identyfikatory

DOI

10.1515/bvip-2015-0065