Effect of different forms of selenium on trace elements in the blood serum and liver tissue of lambs

• Autorzy: Chalabis-Mazurek A. , Walkuska G.

Warianty tytułu

PL

Wpływ różnych form selenu na zawartość metali śladowych w surowicy krwi i wątrobie jagniąt

• Języki publikacji: EN

Abstrakty

EN

The objective of the present research was to evaluate the dynamics of changes in the mineral content in blood serum and liver of lambs under dietary selenium supplementation. The study was conducted on 48 lambs assigned to three equal groups. The experiment started when the lambs were 5 weeks old, proceeded for 8 weeks and consisted of two stages. During the first, 4-week stage, the lambs were divided into three groups: group I – clinical control group, II – which received 0.2 mg Se/day in the form of enriched yeast, and III – which was fed 0.2 mg Se/day in the form of sodium selenite (POCH, Poland). During the second, 4-week stage, the lambs did not receive any supplements. Blood samples were taken after 1, 2, 3 and 4 weeks of the experiment. Liver samples were collected from slaughtered animals after 2, 4, 6 and 8 weeks since the onset of the experiment. Selenium supplementation significantly increased the Se concentration in the blood serum and liver of lambs. Selenium compounds significantly contributed to changes in the analyzed minerals, i.e. manganese, zinc, copper and iron. The results of this experiment suggest that selenium supplementation might lead to a decrease in levels other health-promoting elements such as Zn, Cu and Fe, and an increase in the Mn levels in the liver. Differences in the influence of organic and mineral forms of selenium on the Mn, Zn, and Cu content in the blood serum and liver were noticed. A significant decrease in the copper and iron content may induce symptoms of the deficiency of these trace elements in animals.

PL

Celem badań była ocena dynamiki zmian zawartości składników mineralnych w surowicy i w wątrobie jagniąt po suplementacji diety selenem. Badanie przeprowadzono na 48 jagniętach w wieku 5 tygodni. Doświadczenie trwało 8 tygodni i zostało podzielone na dwie części. W pierwszych 4 tygodniach jagnięta podzielono na trzy równe grupy: Grupę I stanowiły jagnięta kontrolne, grupę II – jagnięta otrzymujące drożdże wzbogacone w selen w dawce 0,2 mg/ dzień/zwierzę, grupę III – jagnięta, którym podawano selen w tej samej dawce co w grupie II w formie seleninu sodu. W drugiej części doświadczenia jagnięta nie otrzymywały suplementacji. Próbki krwi pobierane były po 1, 2, 3, 4 tygodniach eksperymentu, zaś wątroby po uboju po 2, 4, 6, 8 tygodniach od rozpoczęcia doświadczenia. Zastosowanie doustnej suplementacji selenem w sposób istotny przyczyniło się do wzrostu koncentracji tego pierwiastka w surowicy krwi i wątrobie jagniąt, ale jednocześnie spowodowało znaczne zmiany w koncentracji innych składników mineralnych, tj. manganu, cynku, miedzi i żelaza. Wyniki tego doświadczenia wskazują, że podawanie selenu może prowadzić do obniżenia poziomu ważnych dla zdrowia pierwiastków Cu, Zn i Fe oraz wzrostu koncentracji Mn w wątrobie. Stwierdzono różnice w oddziaływaniu organicznych i mineralnych form selenu na zawartość Mn, Zn, Cu w surowicy krwi i wątrobie jagniąt. Znaczny spadek zawartości miedzi i żelaza stwierdzony po zastosowaniu suplementacji selenem może sugerować ryzyko wystąpienia u jagniąt objawów związanych z niedoborem tych pierwiastków.

• Wydawca: -
• Czasopismo: Journal of Elementology
• Rocznik: 2014
• Tom: 19
• Numer: 1
• Opis fizyczny: p.41-53,ref.

Twórcy

autor

Chalabis-Mazurek A.

• Department of Preclinical Veterinary Sciences, University of Life Sciences in Lublin, Akademicka 12, 20-033 Lublin, Poland

autor

Walkuska G.

• Department of Preclinical Veterinary Sciences, University of Life Sciences in Lublin, Lublin, Poland

Bibliografia

• Abdollahi M. 2001. Protection by selenium of lead-acetate-induced alterations on rat subman dibular gland function. Hum. Exp. Toxicol., 20: 28-33.
• Bik D.E. 2003. Mammalian selenoproteins. Med. Wet., 59: 200-203. (in Polish with English summary)
• Bik D., Bednarek D. 1997. Effect of sodium selenite injection on the concentration of magnesium and other bioelements. Biul. Magnezol., 2: 93-97. (in Polish)
• Chałabis-Mazurek A., Wałkuska G. 2008a. The influence of different forms and doses of selenium on its concentration in the serum of lambs. Med. Wet., 64: 1125-1129. (in Polish with English summary)
• Chałabis-Mazurek A., Wałkuska G. 2008b. Influence of different forms of selenium on its retention in selected tissues of lambs. Med. Wet., 64: 1324-1326. (in Polish with English summary)
• Chmielnicka J., Zaręba G., Witasik M., Brzeźnicka E. 1988. Zinc-selenium interaction in the rat. Biol. Trace Elem. Res., 15: 267-276.
• Danek J. 2002. Role of zinc in stallions. Med. Wet., 58: 825-912. (in Polish with English summary)
• Eck P., Pallauf J. 1999. Induction of metallothionein by paraquat injection in zinc-deficient rats. J. Anim. Physiol. Anim. Nutr., 81: 203-211.
• El-Sharaky A.S., Nevairy A.A., Badreldeen M.M., Eweda S.M., Sheweita S.A. 2007. Protective role of selenium against rend toxicity induced by cadmium in rats. Toxicology, 235: 185-193.
• Gehrke M. 1997a. The role of copper and manganese in pathogenesis of bone diseases in animals. Med. Wet., 53: 644–646. (in Polish with English summary)
• Gehrke M. 1997b. The role of manganese in the feeding of ruminants. Med. Wet., 53: 18-21. (in Polish with English summary)
• Gehrke M., Lachowski A. 1999. The relationship between manganese content in the liver and its concentration in the serum of cattle. Med. Wet., 55: 126-128. (in Polish with English summary)
• Grela E.R., Sembratowicz I. 1997. Organic selenium compounds. Med. Wet., 53: 385-386. (in Polish with English summary)
• Hartikainen H. 2005. Biogeochemistry of selenium and its impact on food chain quality and human health. J. Trace Elem. Med. Biol., 18: 309-318.
• Hause W.A., Welch R.M. 1989. Bioavailability of and interactions between zinc and silver in rats fed wheat grain intrinsically labeled with zinc and selenium. J. Nutr., 119: 916-921.
• Hemingway R.G. 2003. The influences of dietary intakes and supplementation with selenium and vitamin E on reproduction diseases and reproductive efficiency in cattle and sheep. Vet. Res. Commun., 27: 159-174.
• Hylland K., Ruus A., Grung M., Green N. 2009. Relationships between physiology, tissue contaminants, and biomarker responses in Atlantic Cod (Gadus morhua L.). J. Toxicol. Environ. Health. Part A, 72: 226-233.
• Jensen L. 1975. Modification of a selenium toxicity in chicks by dietary silver and copper. J. Nutr., 105: 769-775.
• Klebaniuk R., Grela E.R. 2008. Effectiveness of various dietary zinc and copper sources in cow nutrition. Med. Wet., 64: 1252-1255. (in Polish with English summary)
• Koenig K. M., Rode L. M., Cohen R.D., Buckley W. T. 1997. Effects of diet and chemical form of selenium on selenium metabolism in sheep. J. Anim. Sci., 75(3): 817-827.
• Lekatz L. A., Canton J. S., Taylor J. B., Reynolds L. P., Redmer D. A., Vonnahme K.A. 2010a. Maternal selenium supplementation and timing of nutrient restriction in pregnant sheep: effects on maternal endocrine status and placental characteristics. J. Anim. Sci., 88(3): 955-971.
• Lekatz L.A., Ward M.A., Borowicz P.P., Taylor J.B., Redmer D.A., Grazul-Bilska A.T., Reynolds L.P., Caton J.S., Vonnahme K.A. 2010b. Cotyledonary responses to maternal selenium and dietary restriction may influence alterations in fetal weight and fetal liver glycogen in sheep. Anim. Reprod. Sci., 17 (3-4): 216-225.
• Makhoul I.R., Sammour R.N., Diamond E., Shohat I., Tamir A., Shamir R. 2004. Selenium concentrations in maternal and umbilical cord blood at 24-42 weeks of gestation: basis for optimization of selenium supplementation to premature infants. Clin. Nutr., 23: 373-381.
• Martin R.F., Young V.R., Blumberg J., Janghorbani M. 1989. Ascorbic acid-selenite interactions in human studies with an oral dose of 74SeO3 2-. Am. J. Clin. Nutr., 119: 1962-1972.
• Neve J., Molle L. 1986. Direct determination of selenium in human serum by graphite furnace atomic absorption spectroscopy. Improvements due to oxygen ashing in graphite tube Zeeman effect background correction. Acta Pharmacol. Toxicol., 59: 606-609.
• Oh S.H., Whanger P.D., Deagen J.T. 1981. Tissue metallothionein: Dietary interaction of cadmium and zinc with copper, mercury, and silver. J. Toxicol. Environ. Health. Part A, 7: 547-560.
• Park J.H.Y., Grandjean C.J., Antonson D.L., Vanderhoof J.A. 1985. Effects of short-term isolated zinc deficiency on intestinal growth and activities of several brush border enzymes in weanling rats. Pedriatr. Res., 19:1333-1339.
• Ransom-Stern B., Solioz M., Krewski D., Aggett P., Aw T., Baker S., Crump K., Dourson M., Haber L., Hertzberg R., Keen C., Meek B., Rudenko L., Schoeny R., Slob W., Starr T. 2007. Copper and human health: biochemistry, genetics, and strategies for modeling dose-response relationships. J. Toxicol. Environ. Health. Part B, 10: 157-222.
• South P.K., Morris V.C., Smith A.D., Levender O.A. 2000. Effect of selenium deficiency on liver iron stores in mice. Nutr. Res., 20:1027-1040.
• Spears J.W. 2003. Trace minerals bioavailability in ruminants. J. Nutr., 133: 1506-1509.
• Su L., Wang M., Yin S.T., Wang H.L., Chen L., Su L.G., Ruan D.Y. 2008. The interaction of selenium and mercury in the accumulations and oxidative stress of rat tissues. Ecotoxicol. Environ. Saf., 70: 483-489.
• Suttle N.F., Jones D.G., Woolliams C., Woolliams J.A. 1987. Heinz body anemia in lambs with deficiencies of copper or selenium. Brit. J. Nutr., 58: 539-548.
• Szarek J., Przybylska-Gornowicz B., Zasadowski A., Fabczak J. 1997. Effects of a mixed administration of selenium and diazinon on the ultrastructure of hepatocytes in rat. Scand. J. Lab. Anim. Sci., 24(1): 6-11.
• Taylor J.B. 2005. Time-dependent influence of supranutritional organically bound selenium on selenium accumulation in growing weather lambs. J. Anim. Sci., 83: 1186-1193.
• Underwood E.J., Suttle N.F. 1999. The mineral nutrition of livestock. 3th ed. CABI Publishing, New York.
• Van Niekerk F. E., Cloete S. W., Heine E. W., Van Der Merwe G.D., Wellington A., Du Plessis S.,Bekker D. 1996. The effect of selenium supplementation during the early post-mating period on embryonic survival in sheep. J. S. Afr. Vet. Assoc., 67 (4): 209-213.
• White C.L., Martin G.B., Hynd P.I., Chapm an R.E. 1994. The effect of zinc deficiency on wool growth and skin and wool follicle histology of male Merino lambs. Brit. J. Nutr., 71: 425-435.

Uwagi

PL

Rekord w opracowaniu

Identyfikatory

DOI

10.5601/jelem.2014.19.1.609