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2017 | 63 | 4 |

Tytuł artykułu

Pathomorphology of the brain in the acute form of African swine fever

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The brains of 10 infected pigs were examined for histopathology and presence of African swine fever virus (ASFV) DNA ASFV infection induces inflamed meninges, cerebral edema and vascular thrombosis, as well as subdural hematomas. Slight tension in the dura mater, flattening of the gyri and narrowing of the sulci were also observed at four days post infection (dpi). Enlarged perivascular spaces were detected for most vessels of the brain after three to four dpi. Considerable lymphocytic infiltration of the brain tissue was observed at the terminal stage of disease. ASFV was present in all investigated areas of brain beginning from three to four dpi. The isolated virus do not differ from the used in present study Georgia 2007 strain.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

63

Numer

4

Opis fizyczny

p.347-352,fig.,ref.

Twórcy

  • Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., 0014 Yerevan, Armenia
  • Department of Medical Biology, Yerevan State Medical University, 2 Koryun St., 0025 Yerevan, Armenia
  • Department of Epidemiology and Parasitology, RA Agricultural University, 0048 Yerevan, Armenia
  • Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., 0014 Yerevan, Armenia
  • Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., 0014 Yerevan, Armenia
  • Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., 0014 Yerevan, Armenia
  • Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., 0014 Yerevan, Armenia
  • Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St., 0014 Yerevan, Armenia

Bibliografia

  • [1] Takamatsu H., Martins C., Escribano J.M., Alonso C., Dixon L.K., Salas M.L., Revilla Y. 2011. Asfarviridae. In: Virus taxonomy. (Eds. A.M.Q King, M.J. Adams, E.B. Carstens, E.J. Lefkowitz). Ninth Report of the ICTV. Elsevier, Oxford: 153-162.
  • [2] Costard S., Mur L., Lubroth J., Sanchez-Vizcaino J.M., Pfeiffer D.U. 2013. Epidemiology of African swine fever virus. Virus Research 173: 191-197. http://dx.doi.org/10.1016/j.virusres.2012.10.030
  • [3] Blome S., Gabriel C., Beer M. 2013. Pathogenesis of African swine fever in domestic pigs and European wild boar. Virus Research 173: 122-130. https://doi.org/10.1016/j.virusres.2012.10.026
  • [4] Enjuanes L., Carrascosa A.L., Moreno M.A., Viñuela E. 1976. Titration of African swine fever (ASF) virus. Journal of General Virology 32: 471-477.
  • [5] O’Donnell V., Holinka L.G., Gladue D.P., Sanford B., Krug P.W., Lu X., Arzt J., Reese B,, Carrillo C., Risatti G.R., Borca M.V. 2015. African swine fever virus Georgia isolate harboring deletions of MGF360 and MGF505 genes is attenuated in swine and confers protection against challenge with virulent parental virus. Journal of Virology 89: 6048-6056. doi:10.1128/JVI.00554-15
  • [6] Karalyan Z., Zakaryan H., Arzumanyan H., Sargsyan K., Voskanyan H., Hakobyan L., Abroyan L., Avetisyan A., Karalova E. 2012. Pathology of porcine peripheral white blood cells during infection with African swine fever virus. BMC Veterinary Research 28: 8:18. doi:10.1186/1746-6148-8-18
  • [7] Plowright W., Parker J., Staple R.F. 1968. The growth of a virulent strain of African swine fever virus in domestic pigs. The Journal of Hygiene 66: 117-134.
  • [8] Gomez-Villamandos J.C., Bautista M.J., Carrasco L., Caballero M.J., Hervas J., Villeda C.J., Wilkinson P.J., Sierra M.A. 1997. African swine fever virus infection of bone marrow: lesions and pathogenesis. Veterinary Pathology 34: 97-107. https://doi.org/10.1177/030098589703400202
  • [9] Edwards J.F., Dodds W.J., Slauson D.O. 1984. Coagulation changes in African swine fever virus infection. American Journal of Veterinary Research 45: 2414-2420.
  • [10] Zakaryan H., Karalova E., Voskanyan H., Ter-Pogossyan Z., Nersisyan N., Hakobyan A., Saroyan D., Karalyan Z. 2014. Evaluation of hemosta -seological status of pigs experimentally infected with African swine fever virus. Veterinary Microbiology 174: 223-228. https://doi.org/10.1016/j.vetmic.2014.08.029
  • [11] Gomez-Villamandos J.C., Bautista M.J., Sánchez-Cordón P.J., Carrasco L. 2013. Pathology of African swine fever: the role of monocytemacrophage. Virus Research 173: 140-149. http://dx.doi.org/10.1016/j.virusres.2013.01.017
  • [12] Vallée I., Tait S.W., Powell P.P. 2001. African swine fever virus infection of porcine aortic endothelial cells leads to inhibition of inflammatory responses, activation of the thrombotic state, and apoptosis. Journal of Virology 75: 10372-10382. doi:10.1128/JVI.75.21.10372-10382.2001
  • [13] Gomez-Villamandos J.C., Hervás J., Méndez A., Carrasco L., Villeda C.J., Wilkinson P.J., Sierra M.A. 1995. Pathological changes of renal interstitial capillaries in pigs inoculated with two different strains of African swine fever virus. Journal of Compa rative Pathology 112: 283-298. https://doi.org/10.1016/S0021-9975(05)80081-7

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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