Vascular endothelial growth factor expression in dogs suffering from squamous cell carcinoma

• Autorzy: Sobczynska-Rak A. , Polkowska I. , Golynska M. , Szponder T. , Zylinska B. , Lopuszynski W.
• Języki publikacji: EN

Abstrakty

EN

The aim of the present study was to monitor VEGF expression in the blood serum of dogs suffering from squamous cell carcinoma in correlation with the speed of metastasis. The research material consisted of tumour tissue and blood samples collected from 26 dogs of various breeds, aged between 5 and 15 years, and 10 control group animals. Blood samples were centrifuged, and the serum obtained was examined by immunoenzymatic assays to determine vascular endothelial growth factor (VEGF) levels. The study group animals were observed for a period of 6 months, during which their blood was drawn twice for immunoenzymatic tests. In all study group animals, elevated blood serum VEGF levels were observed on the day of surgery compared with the control group. In 14 cases, disease relapse was observed with metastases to the bones or lungs. In all relapsing animals, significantly higher blood serum VEGF levels were observed. VEGF levels are closely related to the neoplastic process, but the exact mechanism of the factor’s involvement in neoplastic progression remains unclear, as does the complexity of the angiogenic processes. Studies of the mechanisms affecting tumour proliferation and the monitoring of VEGF levels can facilitate better diagnostics and prognostics, as well as improve the effectiveness of cancer treatment and the planning of new therapeutic strategies for both human and animal patients.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2017
• Tom: 73
• Numer: 05
• Opis fizyczny: p.289-294,fig.,ref.

Twórcy

autor

Sobczynska-Rak A.

• Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, ul. Gleboka 30, 20-612 Lublin, Poland

autor

Polkowska I.

• Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, ul. Gleboka 30, 20-612 Lublin, Poland

autor

Golynska M.

• Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, ul. Gleboka 30, 20-612 Lublin, Poland

autor

Szponder T.

• Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, ul. Gleboka 30, 20-612 Lublin, Poland

autor

Zylinska B.

• Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, ul. Gleboka 30, 20-612 Lublin, Poland

autor

Lopuszynski W.

• Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, ul. Gleboka 30, 20-612 Lublin, Poland

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Identyfikatory

DOI

10.21521/mw.5693