The use of unbiased conditioned place preference procedure as the predictive analysis of vulnerability to psychostimulant addiction in rats

• Autorzy: Niedzielska E. , Pomierny-Chamiolo L. , Filip M.
• Języki publikacji: EN

Abstrakty

EN

As in humans, also in laboratory animals, addiction phenotype including drug craving and relapses, develops only in about 20% subjects following initial drug abuse. The aim of our study was to verify if the conditioned place preference (CPP) paradigm can serve as a model for determination of the variable vulnerability to drug addiction. We used male Wistar rats (250–300 g) housed under standard laboratory conditions. Animals were exposed to either vehicle (n=20) or to the psychostimulant cocaine (15 mg/kg, ip; n=64) during 10 days with CPP. As a result, 15 animals (i.e., 23.4% of all experimental animals) that performed unbiased version of CPP, spent more time in cocaine-paired chamber in test in comparison to pretest (P<0.0005 vs. control); those rats were classified as addiction vulnerable. In conclusion, our results suggest that unbiased conditioned place preference procedure can serve as an animal model for predictive analysis of vulnerability to psychostimulant addiction in rats. Moreover, it also gives the opportunity to study the phenotype of animals (so called addiction-resistant) which did not develop drugassociated environment-linked craving.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.357

Twórcy

autor

Niedzielska E.

• Department of Toxicology, Faculty of Pharmacy, Collegium Medicum, Jagiellonian University, Cracow, Poland

autor

Pomierny-Chamiolo L.

• Department of Toxicology, Faculty of Pharmacy, Collegium Medicum, Jagiellonian University, Cracow, Poland

autor

Filip M.

• Department of Toxicology, Faculty of Pharmacy, Collegium Medicum, Jagiellonian University, Cracow, Poland