Cytotoxic activity of Serratia marcescens clinical isolates

• Autorzy: Krzyminska S. , Raczkowska M. , Kaznowski A.
• Języki publikacji: EN

Abstrakty

EN

Twenty Serratia marcescens isolates from clinical specimens were examined for their cytotoxic activity on four cell lines (HEp-2, Vero, CHO, J774). Most of the isolates were found to be cytotoxic to CHO (70%), Vero (75%) and HEp-2 cells (90%). CHO cells were the most sensitive to cell-free supematants, followed by HEp-2 and Vero cells. Two strains produced cytotonic toxins which caused elongation of CHO cells. Moreover, twelve isolates (60%) revealed cytotoxic potential to macrophage cell line J774. The results indicate that these bacteria may destroy phagocytes and epithelial cells, which may lead to spread within the host.

Słowa kluczowe

EN

cytotoxic activity; Serratia marcescens; clinical isolate; human disease; bacterial strain; cytotoxicity

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2010
• Tom: 59
• Numer: 3
• Opis fizyczny: p.201-205,fig.,ref.

Twórcy

autor

Krzyminska S.

• Department of Microbiology, Faculty of Biology, A.Mickiewicz University, Poznan, Poland

autor

Raczkowska M.

• Department of Microbiology, Faculty of Biology, A.Mickiewicz University, Poznan, Poland

autor

Kaznowski A.

• Department of Microbiology, Faculty of Biology, A.Mickiewicz University, Poznan, Poland

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