Olfactory sensivity deficit in the MPTP model of PD as a consequence of biochemical lateralization and noradrenergic depletion in the olfactory bulbs

• Autorzy: Boguszewski P.M. , Zaremba M. , Joniec-Maciejak I. , Kurkowska-Jastrzebska I.
• Języki publikacji: EN

Abstrakty

EN

BACKGROUND AND AIMS: Parkinson disease (PD) is a more general disease than thought previously and involves prominent nonmotor manifestations (e.g. anosmia, hyposmia). Olfactory dysfunction can precede onset of motor symptoms by up to 10 years and they might provide biomarkers of the pathogenetic process. The initiating neurobiological bases for such disturbance are still elusive. However, recent findings suggest a degree of independence of olfactory dysfunction from nigrostriatal dopamine (DA). The aim of this study was to assess the extent of influence of biochemical imbalance in the left and right olfactory bulbs (OBs) on olfaction in old (1 or 1.5 year) mice caused by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) intoxication. METHODS: The olfactory capability was evaluated using a battery set of olfaction tests: The Buried Food Test (BFT), Olfactory Discrimination Test (ODT), Olfactory Sensitivity Test (OST). Noradrenaline (NE) and DA metabolism was evaluated by High-performance liquid chromatography (HPLC) method. RESULTS: Intraperitoneal administration of MPTP caused significant reduction in NE and DA contents, observed mostly in the right OB at 7 and 180 days post intoxication. Interestingly, diminished noradrenergic projection and intensification of compensatory mechanism in the right OB exerted disturbing effect in some olfaction test (OST, BFT). Compared to controls, MPTP mice displayed insensitivity to low concentration odors in the OST and spend more time to find a buried food in the BFT. CONCLUSIONS: Results of the study strong indicate on lateralization in the OBs. Reasons for this phenomenon are unknown, although they may reflect lateralized differences in the function of the two sides of OBs. Diminished NE projection may play more important role in odor sensitivity than DA and may be related to dysfunction in odor recognition (hyposmia).The present findings seem to justify future studies about possible role of NE for therapeutic manipulation in PD.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S62

Twórcy

autor

Boguszewski P.M.

• Laboratory of Limbic System, Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

autor

Zaremba M.

• Laboratory of Limbic System, Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
• Environmental Laboratory of Magnetic Resonance Imaging of Small Animals, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Joniec-Maciejak I.

• Centre for Preclinical Research and Technology, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Kurkowska-Jastrzebska I.

• 2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland