Projection from the locus coeruleus to the cerebellar caudal vermis: fluorescent tracing study in the rabbit

• Autorzy: Zguczynski L. , Bukowska D.
• Języki publikacji: EN

Abstrakty

EN

The locus coeruleus (LC) located in the pontine tegmentum, is the major noradrenergic nucleus of the brain. It gives rise to fibers innervating extensive areas within the neuraxis, among other the cerebral cortex, basal forebrain, limbic system, thalamus, brainstem autonomic nuclei, spinal cord. Throughout these projections, LC as a crucial wakefulness-promoting nucleus, is involved in neuronal circuits controlling a number of physiological functions, e.g., regulation of arousal and autonomic activity. A few data concerning the LC-cerebellar projections indicate, that LC sends same fibers to the cerebellar vermis, and small collateral projection to both the cerebral cortex and cerebellum exist as well. The aim of present study was to identify LC neurons projecting to the caudal vermal lobule, i.e. the pyramis. Following fluorescent tracer injection into the pyramis, retrogradely labelled neurons, as parent for the LC – pyramis projection, were found in defined regions of LC. The projection is bilateral with ipsilateral predominance (82% ipsiversus 18% contralateral). The LC noradrenergic connections may modulate response of the pyramis neurons and exert influence on activity of the postural muscles of upper trunk and the proximal forelimb muscles.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.40

Twórcy

autor

Zguczynski L.

• Department of Anatomy, Biology and Health Sciences, University School of Physical Education, Gorzow Wlielkopolsk, Poland

autor

Bukowska D.

• Department of Neurobiology, University School of Physical Education, Poznan, Poland