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2017 | 73 | 08 |

Tytuł artykułu

Płyn ustny jako materiał nieinwazyjnego wykrywania antybiotyków u świń

Autorzy

Warianty tytułu

EN
Oral fluid as material for non-invasive antibiotics detection in pigs

Języki publikacji

PL

Abstrakty

EN
Intensive and massive pig production often contributes to excessive administration of antibacterials in veterinary medicine. The misuse and failures to follow the label directions of antibiotics, as well as withdrawal inadequacy, can lead to their residue occurrence in products of animal origin. The residue of drugs may result in many biological adverse effects and allergic reactions in consumers as well as the spread of drug-resistant bacteria and bacterial resistance acquisition. Consolidation of pig production requires ensuring adequate conditions of the maintenance of animals with high health conditions, consistent with the guidelines for animal welfare. At the same time, the control of antibiotics in animals is an important element providing the high quality of pigs breeding, as well as the protection of consumers. In residue monitoring programs, the primary material for the control of antibiotics presence in pigs are tissue samples, collected from animals at the slaughterhouse. However, post-mortem analysis does not give the opportunity of monitoring the usage of antibiotics on the farm during the breeding of animals. In ante mortem drug analysis blood can be used as a diagnostic biological matrix; however, blood sampling is connected with certain disadvantages for the animals and the staff responsible for material collection. The post-mortem detection and presence of antibiotic residues in pork tissues above MRL values very often lead to the recall and destruction of significant quantities of meat, which may contribute to economic losses. Therefore, a strong need to find and implement new methods for ante-mortem detection of antibiotics in animals exists, which minimize interference in animal welfare. The results of preliminary studies demonstrate that oral fluid seems to be an effective tool for monitoring the reasonable treatment and residue avoidance. It offers a cost-effective approach for the screening of large populations of animals. The method of oral fluid collection with cotton rope usage allows for the rapid sampling of material. In case of positive oral fluid ante-mortem analysis results, the slaughtering of animals can be delayed, which can bring the avoidance of costs connected with the non-compliant pig meat destruction.

Wydawca

-

Rocznik

Tom

73

Numer

08

Opis fizyczny

s.462-467,fot.,bibliogr.

Twórcy

autor
  • Zakład Farmakologii i Toksykologii, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy w Puławach, Al.Partyzantów 57, 24-100 Puławy
autor
  • Zakład Farmakologii i Toksykologii, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy w Puławach, Al.Partyzantów 57, 24-100 Puławy

Bibliografia

  • Alboral L. G., Gradassi M., Pavesi R., Boniotti B., Nassuato C., Glovannini S., Glacomini E., Bellini S., Pcciarini M.: Detection of PRRSV in oral fluid samples; longitudinal study under field conditions. Proc. 21 Congress IPVS, Vancouver, Cnada, 2010, s. 483.
  • Commission Decision 2002/657/EC of August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off. J. Eur. Commun. L 221, 8-36.
  • Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Off. J. Eur. Commun. L 15:1-77.
  • Council Directive 96/23/EC of 29 April 1996 on measures to monitor certain substances and residues thereof in live animals and animal products and repealing Directives 85/358/EEC, 86/469/EEC and Decision 89/187/EEC and 91/664/EEC. OJ L 1996, 125, 10-31.
  • Danhof M., Breimer D. D.: Therapeutic drug monitoring in saliva. Clin. Pharmacokinet. 1978, 3, 39-57.
  • Drobitch R. K., Svensson C. K.: Therapeutic drug monitoring in saliva. An update. Clin. Pharmacokinet. 1992, 23, 365-379.
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  • Girardi C., Odore R.: Pharmacological treatments and risks for food chain. Vet. Res. Commun. 2008, 32 (Suppl 1), S11-S18.
  • Haeckel R.: Factors influencing the saliva/plasma ratio of drugs. Ann. NY Acad. Sci.1993, 694, 128-142.
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  • Haeckel R., Hanecke P.: The application of saliva, sweat and tear fluid for diagnostic purposes. Ann. Biol. Clin. 1993, 51, 903-910.
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  • Kittawornrat A., Prickett J., Wang C., Olsen C., Irwin C., Panyasing Y., Ballagi A., Rice A., Main R., Johnson J., Rademacher C., Hoogland M., Rowland R., Zimmerman J.: Detection of Porcine reproductive and respiratory syndrome virus (PRRSV) antibodies in oral fluid specimens using a commercial PRRSV serum antibody enzyme-linked immunosorbent assay. J. Vet. Diagn. Invest. 2012, 24, 262-269.
  • Lui P., Muller M., Derendorf H.: Rational dosing of antibiotics: the use of plasma comcentrations versus tissue concentrations. Int. J. Antimicrob. Ag. 2002, 19, 285-290.
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  • Meiszberg A., Karriker L., Zimmerman J., Irwin C. H., Coetzee J.: Detection of ceftiofur and oxytetracycline in oral fluids of swine with a pen-side competitive ELISA test after intramuscular injection. J. Vet. Pharmacol. Ther. 2011, 34, 515-517.
  • Olsen C., Karriker L., Wang C., Binjawadagi B., Renukaradhya G., Kittawornrat A., Lizano S., Coetzee J., Main R., Meiszberg A., Panyasing Y., Zimmerman J.: Effect of collection material and sample processing on pig oral fluid testing results. Vet. J. 2013, 198, 159-163.
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  • Posyniak A.: Występowanie antybiotyków w żywności – aspekty prawne i analityczne kontroli pozostałości. Życie Wet. 2011, 86, 717-720.
  • Prickett J. R., Kim W., Simer R., Yoon K. J., Zimmerman J.: Oral fluid samples for surveillance of commercial growing pigs for porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 infections. J. Swine Health Prod. 2008, 16, 86-91.
  • Prickett J. R., Zimmerman J.: The development of oral fluid-based diagnostics and applications in veterinary medicine. Anim. Health Res. Rev. 2010, 11, 207-216.
  • Rożańska H., Lewak-Piłat A.: Metody przesiewowe wykrywania pozostałości antybiotyków w żywności. Życie Wet. 2011, 86, 59-61.
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  • Stolker A. A. M., Brinkman U. A. Th.: Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals – a review. J. Chromatogr. A 2005, 1067, 15-53.
  • White D., Rotolo M., Olsen Ch., Wang Ch., Prickett J., Kittawornrat A., Panyasing Y., Main R., Rademacher Ch., Hoogland M., Zimmerman J. J.: Recommendations for pen based oral-fluid collection in growing pigs. J. Swine Health Prod. 2014, 22, 138-141.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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