Are lycopene metabolites metabolically active?

• Autorzy: Ford N. A. , Erdman J. W.,. J.
• Języki publikacji: EN

Abstrakty

EN

 Lycopene is the most abundant carotenoid found in tomatoes and thus has been touted as the bioactive component for the reduced risk of chronic diseases such as prostate cancer. We and others hypothesize that lycopene metabolites are responsible for positively modulating biomarkers and risk factors for the prevention of chronic diseases. Lycopene metabolites circulate in serum and accumulate in tissues at concentrations equivalent to bioactive retinoids. Recent studies report that lycopene metabolites reduce the proliferation of cancer cells, induce apoptosis, enhance gap junction communication between cells, alter normal cell cycle progression, and modulate androgen signaling pathways. Here we review recent literature and provide new evidence to suggest that lycopene metabolites may be bioactive at physiological concentrations.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 1
• Opis fizyczny: p.1-4,fig.,ref.

Twórcy

autor

Ford N. A.

• Department of Nutritional Sciences, University of Texas, Austin, TX USA

autor

Erdman J. W.,. J.

Bibliografia

• Canene-Adams K, Campbell JK, Zaripheh S, Jeffery EH, Erdman JW Jr (2005) The tomato as a functional food. J Nutr 135: 1226-1230.  
• Caris-Veyrat C, Schmid A, Carail M, Bohm V (2003) Cleavage products of lycopene produced by in vitro oxidations: Characterization and mechanisms of formation. J Agric Food Chem 51: 7318-7325.  
• De Leenheer AP, Lambert WE, Claeys I (1982) All-trans-retinoic acid: Measurement of reference values in human serum by high performance liquid chromatography. J Lipid Res 23: 1362-1367.  
• Ebling DW, Ruffer J, Whittington R, Vanarsdalen K, Broderick GA, Malkowicz SB, Wein AJ (1997) Development of prostate cancer after pituitary dysfunction: A report of 8 patients. Urology 49: 564-568.  
• Ford NA, Erdman JW Jr (2008) Lycopene metabolites: Apo-lycopenals. Lycopene: Nutr, Med, and Ther Prop 37-63.
• Ford NA, Elsen AC, Zuniga K, Lindshield BL, Erdman JW Jr (2011a) Lycopene and apo-12'-lycopenal reduce cell proliferation and alter cell cycle progression in human prostate cancer cells. Nutr Cancer 63: 256-263.  
• Ford NA, Moran NE, Smith JW, Clinton SK, Erdman JW Jr (2011b) An interaction between carotene-15,15'-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone. Int J Cancer  
• Ford NA, Clinton SK, von Lintig J, Wyss A, Erdman JW Jr (2010) Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice. J Nutr 140: 2134-2138.  
• Gajic M, Zaripheh S, Sun F, Erdman JW Jr (2006) Apo-8'-lycopenal and apo-12'-lycopenal are metabolic products of lycopene in rat liver. J Nutr 136: 1552-1557.  
• Gann PH, Hennekens CH, Ma J, Longcope C, Stampfer MJ (1996) Prospective study of sex hormone levels and risk of prostate cancer. J Natl Cancer Inst 88: 1118-1126.  
• Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC (1995) Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 87: 1767-1776.  
• Hessel S, Eichinger A, Isken A, Amengual J, Hunzelmann S, Hoeller U, Elste V, Hunziker W, Goralczyk R, Oberhauser V, von Lintig J, Wyss A (2007) CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice. J Biol Chem 282: 33553-33561.  
• Hu KQ, Liu C, Ernst H, Krinsky NI, Russell RM, Wang XD (2006) The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. J Biol Chem 281: 19327-19338.  
• Huggins C, Hodges CV (2002) Studies on prostatic cancer: I. the effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941. J Urol 168: 9-12.  
• Khachik F, Pfander H, Traber B (1998a) Proposed mechanisms for the formation of synthetic and naturally occurring metabolites of lycopene in tomato products and human serum. J Agric Food Chem 46: 4885-4890.
• Khachik F, Steck A, Niggli U, Pfander H (1998b) Partial synthesis and structural elucidation of the oxidative metabolites of lycopene identified in tomato paste, tomato juice, and human serum. J Agric Food Chem 46: 4874-4884.
• Kim SJ, Nara E, Kobayashi H, Terao J, Nagao A (2001) Formation of cleavage products by autoxidation of lycopene. Lipids 36: 191-9.  
• King TJ, Khachik F, Bortkiewicz H, Fukushima LH, Morioka S, Bertram JS (1997) Metabolites of dietary carotenoids as potential cancer preventive agents. Pure Appl Chem 69: 2135-2140.
• Kopec RE, Riedl KM, Harrison EH, Curley RW,Jr, Hruszkewycz DP, Clinton SK, Schwartz SJ (2010) Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma. J Agric Food Chem 58: 3290-3296.  
• Lian F, Smith DE, Ernst H, Russell RM, Wang XD (2007) Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis 28: 1567-1574.  
• Lindqvist A, He YG, Andersson S (2005) Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues. J Histochem Cytochem 53: 1403-1412.  
• Lindshield BL, Canene-Adams K, Erdman JW Jr (2007) Lycopenoids: Are lycopene metabolites bioactive? Arch Biochem Biophys 458: 136-140.  
• Linnewiel K, Ernst H, Caris-Veyrat C, Ben-Dor A, Kampf A, Salman H, Danilenko M, Levy J, Sharoni Y (2009) Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system. Free Radic Biol Med 47: 659-667.  
• Mein JR, Lian F, Wang XD (2008) Biological activity of lycopene metabolites: Implications for cancer prevention. Nutr Rev 66: 667-683.  
• Roberts JT, Essenhigh DM (1986) Adenocarcinoma of prostate in 40-year-old body-builder. Lancet 2: 742.  
• Shaneyfelt T, Husein R, Bubley G, Mantzoros CS (2000) Hormonal predictors of prostate cancer: A meta-analysis. J Clin Oncol 18: 847-853.  
• Wyss A (2004) Carotene oxygenases: A new family of double bond cleavage enzymes. J Nutr 134: 246S-250S.  
• Zaripheh S, Nara TY, Nakamura MT, Erdman JW Jr (2006) Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues. J Nutr 136: 932-938.  
• Zhang H, Kotake-Nara E, Ono H, Nagao A (2003) A novel cleavage product formed by autoxidation of lycopene induces apoptosis in HL-60 cells. Free Radic Biol Med 35: 1653-1663

Uwagi

PL

Rekord w opracowaniu.