Use of elements of the Stewart model (Strong Ion Approach) - SID3, SID4, Atot/Aminus, SIDe and SIG for the diagnostics of respiratory acidosis in brachycephalic dogs

• Autorzy: Slawuta P. , Sapikowski G. , Sobieraj B.
• Języki publikacji: EN

Abstrakty

EN

Buffer systems of blood and tissues, which have the ability to bind with and give up hydrogen ions, participate in maintaining the acid-base balance (ABB) of the organism. According to the classic model, the system of carbonic acid and bicarbonates, where the first component serves the role of an acid and the second a base, determines plasma pH. The so-called Stewart model, which assumes that ions in blood serum can be separated into completely dissociated – nonbuffer and not dissociated – buffer ions which may give up or accept H+ions, also describes the ABB of the organism. The goal of the study was to find out whether, during respiratory acidosis, the values of SID3, SID4, Atot/A−, SIDe and SIG change. The study was carried out on 60 adult dogs of the boxer breed (32 males and 28 females) in which, on the basis of an arterial blood test, respiratory acidosis was found. A strong overgrowth of the soft palate tissue requiring a surgical correction was the cause of the ABB disorder. Prior to surgery and on the 14th day after the surgery, venous and arterial blood was drawn from each dog. ABB parameters were determined in the arterial blood sample: the blood pH, pCO2 and HCO3−. In the venous blood, concentration of Na+, K+, Cl−, lactate−, albumins, and Pinorganic was determined. On the basis of the obtained data, the values of SID3, SID4, SIDe, A− and SIG, before and after the surgery, were calculated. In spite of the fact that the average concentration of ions, albumins, Pinorganic and lactate in the blood serum of dogs before and after the surgical procedure was similar and within the physiological norms, the values of SID3, SIDe and SIG, calculated on the basis of the former, displayed statistically significant differences. Conclusion: On the basis of the results obtained, it can be stated that the values of SID3, SIDe and SIG change during respiratory acidosis and may be helpful in the diagnostics of ABB disorders in brachycephalic dogs.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2016
• Tom: 19
• Numer: 3
• Opis fizyczny: p.633-638,ref.

Twórcy

autor

Slawuta P.

• Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland

autor

Sapikowski G.

• Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland

autor

Sobieraj B.

• Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland

Bibliografia

• Ambros B, Duke-Novakovski T, Pasloske KS (2008) Comparison of the anesthetic efficacy and cardiopulmonary effects of continuous rate infusions of alfaxalone-2-hydroxypropyl-beta-cyclodextrin and propofol in dogs. Am J Vet Res 69: 1391-1398.
• Balakrishnan S, Gopalakrishnan M, Alagesan M, Prakash ES (2007) What is the ultimate goal in acid-base regulation? Adv Physiol Educ 31: 51-54.
• Boyle M, Baldwin I (2002) Introduction to an alternate view of acid/base balance: the strong ion difference or Stewart approach. Aust Crit Care 15: 14-20.
• Constable PD (2000) Clinical assessment of acid-base status: comparison of the Henderson-Hasselbalch and strong ion approaches. Vet Clin Pathol 29: 115-128.
• Constable PD (2003) Hyperchloremic acidosis: the classic example of strong ion acidosis. Anesth Analg 96: 919-922.
• Constable PD, Stampfli HR (2005) Experimental determination of net protein charge and A(tot) and K(a) of nonvolatile buffers in canine plasma. J Vet Intern Med 19: 507-514.
• Corey HE (2005) Bench-to-bedside review: Fundamental principles of acid-base physiology. Crit Care 9: 184-192.
• Covey-Crump GL, Murison PJ (2008) Fentanyl or midazolam for co-induction of anaesthesia with propofol in dogs. Vet Anaesth Analg 35: 463-472.
• De Morais HS, Di Bartola SP (1991) Ventilatory and metabolic compensation in dogs with acid-base disturbances. J Vet Emerg Crit Care 1: 39-49.
• Di Bartola SP (2006) Introduction to acid – base disorders. In: DiBartola SP (ed) Fluid, electrolyte and acid base disorders in small animal practice. Saunders Elsevier, St Louis, pp 229-251.
• Enouri SS, Kerr CL, McDonell WN, Dyson DH (2008) Cardiopulmonary effects of anesthetic induction with thiopental, propofol, or a combination of ketamine hydrochloride and diazepam in dogs sedated with a combination of medetomidine and hydromorphone. Am J Vet Res 69: 586-595.
• Fencl V, Jabor A, Kazda A, Figge J (2000) Diagnosis of metabolic acid-base disturbances in critically ill patients. Am J Respir Crit Care Med 162: 2246-2251.
• Figge J, Jabor A, Kazda A, Fencl V (1998) Anion gap and hypoalbuminemia. Crit Care Med 26: 1807-1810.
• Figge J, Rossing TH, Fencl V (1991) The role of serum proteins in acid-base equilibria. J Lab Clin Med 117: 453-467.
• Grint NJ, Alderson B, Dugdale AH (2010) A comparison of acepromazine-buprenorphine and medetomidine-buprenorphine for preanesthetic medication of dogs. J Am Vet Med Assoc 237: 1431-1437.
• Hoareau GL, Jourdan G, Mellema M, Verwaerde P (2012) Evaluation of arterial blood gases and arterial blood pressures in brachycephalic dogs. J Vet Intern Med 26: 897-904.
• Hopper K, Epstein SE, Kass PH, Mellema MS (2014a) Evaluation of acid-base disorders in dogs and cats presenting to an emergency room. Part 1: comparison of three methods of acid-base analysis. J Vet Emerg Crit Care (San Antonio) 24: 493-501.
• Hopper K, Epstein SE, Kass PH, Mellema MS (2014b) Evaluation of acid-base disorders in dogs and cats presenting to an emergency room. Part 2: comparison of anion gap, strong ion gap, and semiquantitative analysis. J Vet Emerg Crit Care (San Antonio) 24: 502-508.
• Kellum JA (2000) Determinants of blood pH in health and disease. Crit Care 4: 6-14.
• Kellum JA, Kramer DJ, Pinsky MR (1995) Strong ion gap: a methodology for exploring unexplained anions. J Crit Care 10: 51-55.
• McCullough SM, Constable PD (2003) Calculation of the total plasma concentration of nonvolatile weak acids and the effective dissociation constant of nonvolatile buffers in plasma for use in the strong ion approach to acid-base balance in cats. Am J Vet Res 64: 1047-1051.
• Morris CG, Low J (2008) Metabolic acidosis in the critically ill: part 1. Classification and pathophysiology. Anaesthesia 63: 294-301.
• Oh YK (2010) Acid-base disorders in ICU patients. Electrolyte Blood Press 8: 66-71.
• Rehm M, Conzen PF, Peter K, Finsterer U (2004) The Stewart model. „Modern” approach to the interpretation of the acid-base metabolism. Anaesthesist 53: 347-357.
• Russell KE, Hansen BD, Stevens JB (1996) Strong ion difference approach to acid-base imbalances with clinical applications to dogs and cats. Vet Clin North Am Small Anim Pract 26: 1185-1201.
• Siegling-Vlitakis C, Kohn B, Kellermeier C, Schmitz R, Hartmann H (2007) Qualification of the Stewart variables for the assessment of the acid-base status in healthy dogs and dogs with different diseases. Berl Munch Tierarztl Wochenschr 120: 148-155.
• Sławuta P, Glińska-Suchocka K, Cekiera A (2015) The use of elements of the Stewart model (Strong Ion Approach) for the diagnostics of respiratory acidosis on the basis of the calculation of a value of a modified anion gap (AGm) in brachycephalic dogs. Pol J Vet Sci 18: 217-222.
• Sławuta P, Nicpoń J, Domańska S (2011) Influence of the wing-of-the-nostrils correction procedure on the change of the acid-base balance parameters and oxygen concentration in the arterial blood in French bulldogs. Pol J Vet Sci 14: 77-80.
• Sławuta P, Nicpoń J, Skrzypczak P (2010) Contemporary approach to acid-base balance and its disorders in dogs and cats Pol J Vet Sci 13: 561-567.
• Stewart PA (1978) Independent and dependent variables of acid -base control. Respir Physiol 33: 9-26.
• Stewart PA (1983) Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 61: 1444-1461.
• Wagner J, Rieker T, Siegling-Vlitakis C (2015) Blood gas analysis in dogs in veterinary practice. A review. Tierarztl Prax Ausg K Kleintiere Heimtiere 43: 260-272.
• Wooten EW (2004) Science review: quantitative acid-base physiology using the Stewart model. Crit Care 8: 448-452.

Identyfikatory

DOI

10.1515/pjvs-2016-0079