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2017 | 77 | Suppl.1 |

Tytuł artykułu

Reduction in cholinergic and glutamatergic innervation of ankle extensor but not flexor motoneurons after spinalization calls for selective therapies

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EN
Five weeks after spinal cord transection (SCT) at low thoracic segments the number of cholinergic C-terminals, expressing VAChT and glutamatergic terminals of proprioceptive input expressing VGluT1 decreased profoundly on perikarya of soleus α‑motoneurons (Sol Mns). However, their number apposing tibialis anterior (TA) Mns was not affected by SCT. Long‑term locomotor training only partly counteracted deficit in the number of both cholinergic and VGluT1 glutamatergic terminals on Sol Mns. These observations point to high vulnerability of ankle extensor Mns to SCT and sensitivity of both excitatory inputs to the training. These prompted us to apply a selective method of enhancing proprioceptive signaling to ankle extensor Mns. In intact rats 7-days of electrical stimulation of low-threshold proprioceptive afferents in tibial nerve, verified by means of H‑reflex, increased both the number and aggregate volume of cholinergic terminals on Mns of lateral gastrocnemius (LG), a synergist of Sol. It similarly affected proprioceptive glutamatergic innervation of LG Mns. However, this paradigm of activation of LG Mns applied shortly after spinal cord transection did not bring enrichment of their innervation, opening a discussion on optimal parameters of stimulation. FINANCIAL SUPPORT: Supported by grants: National Science Centre 2013/09/B/NZ4/03306, statutory for the Nencki Institute.

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77

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Opis fizyczny

p.26

Twórcy

  • Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

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