Effects of lithium and valproate on cognitive judgment bias of rats in the ambiguous-cue interpretation paradigm

• Autorzy: Rygula R. , Golebiowska J. , Kregiel J.
• Języki publikacji: EN

Abstrakty

EN

Mania is a debilitating psychiatric condition and a cardinal feature of Bipolar Disorder. One of the critical features of mania is over-optimistic judgment bias leading to high-risk behaviors. As both; lithium and valproate are well-established treatments for mania in humans, in the present study, using recently developed ambiguous-cue interpretation test (ACI) we assessed the effects of treatment with these two drugs on cognitive judgment bias in rats. To accomplish this goal, in two separate experiments, previously trained animals were treated with 3 different doses of either valproate (100, 200 and 400 mg/kg) or lithium chloride (10, 50 and 100 mg/kg) and were subsequently tested with the ACI paradigm. The drugs were administered using fully randomized Latin square designs. Control animals received physiological saline injections. We report that neither valproate nor lithium chloride had significant effects on ambiguous-cue interpretation in rats. Supported by Polish Ministry of Science and Higher Education (Research grant: Iuventus Plus IP2011047271 to RR) and the statutory funds of the Institute of Pharmacology PAS.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.358

Twórcy

autor

Rygula R.

• Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology Polish Academy of Sciences, Cracow, Poland

autor

Golebiowska J.

• Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology Polish Academy of Sciences, Cracow, Poland

autor

Kregiel J.

• Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology Polish Academy of Sciences, Cracow, Poland